C.J.Gorter Center for High Field MRI

General Information

The C.J.Gorter Center for High Field Magnetic Resonance was opened in the autumn of 2007. Its mission is to develop new techniques for high field clinical applications of MRI. Facilities include a Philips Achieva 7 tesla whole body MRI, as well as access to 3 tesla and 1.5 tesla Philips research scanners and a 7 tesla Bruker Pharmascan. In collaboration with the Leiden institute of Chemisty we have access to 9.4 tesla and 17.6 tesla Bruker systems.

Current Projects

  • Susceptibility weighted imaging (SWI)
  • High frequency RF coil development
  • Cardiac imaging
  • Perfusion imaging
  • MRS and MRI in Duchenne muscular dystrophy
  • Muscle and brain spectroscopy
  • Cartilage imaging
  • Post-mortem brain imaging
  • Biological interpretation of MRI contrasts
  • Diffusion Weighted MRS - method development and applications


Faculty:

  • Andrew Webb, Professor, Director
  • Mark van Buchem, Professor, Clinical Director
  • Thijs van Osch, Associate Professor
  • Hermien Kan, Associate Professor
  • Itamar Ronen, Associate Professor
  • Louise van der Weerd, Associate Professor
  • Peter Börnert, Professor

Staff:

  • Paul de Bruin, Medical Physicist
  • Wouter Teeuwisse, Laboratory Supervisor

Postdocs:

  • Celine Baligand
  • Jan-Willem Beenakker
  • Wyger Brink
  • Jedrec Burakiewicz
  • Marc Derieppe
  • Natalie Doorenweerd
  • Sanneke van Rooden
  • Sophie Schmid
  • Irena Zivkovic

PhD Students:

  • Marjolein Bulk
  • Suzanne Franklin
  • Jeroen van Gemert
  • Melissa Hooijmans
  • Bauke Kogelman
  • Kirsten Koolstra
  • Laure Grand Moursel
  • Lorna Grech Fonk
  • Thijs van Harten
  • Ruben Hendriksen
  • Reijer Leijssen
  • Leon Munting
  • Léonie Petitclerc
  • Merlijn van der Plas
  • Dana Poole
  • Maarten Rotman
  • Thomas Ruytenberg
  • Sanny Scheffer
  • Yuriko Suzuki
  • Jasper Verbree
  • Luc van Vught
  • Joep Wezel

Technicians:

  • Linda van der Graaf
  • Ernst Suidgeest

Master students:

  • Wico Breimer
  • Roel Burgwal
  • Thomas O'Reilly
  • Karina Soemarwoto

Recent publications

  • Wokke BH, Van Den Bergen JC, Hooijmans MT, Verschuuren JJ, Niks EH, Kan HE.T2 relaxation times are increased in Skeletal muscle of DMD but not BMD patients.Muscle Nerve. 2016 Jan;53(1):38-43. 
  • Andersen M, Hanson LG, Madsen KH, Wezel J, Boer V, van der Velden T, van Osch MJ, Klomp D, Webb AG, Versluis MJ. Measuring motion-induced B0 -fluctuations in the brain using field probes. Magn Reson Med. 2015 [Epub ahead of print]
  • Schmid S, Teeuwisse WM, Lu H, van Osch MJ. Time efficient determination of spin compartments by Time Encoded pCASL T2-Relaxation-Under-Spin-Tagging and its application in hemodynamic characterization of the cerebral border zones. NeuroImage  2015 Dec;123:72-9
  • Hooijmans MT, Damon BM, Froeling M, Verschuuren JJ, Burakewicz J, Niks EH, Webb AG, Kan HE. Evaluation of skeletal muscle DTI in patients with Duchenne Muscular Dystrophy. NMR Biomed. 2015 Nov;28(11):1589-97. 
  • Wood ET, Ercan AE, Branzoli F, Webb A, Sati P, Reich DS, Ronen I.Reproducibility and optimization of in vivo human diffusion-weighted MRS of the corpus callosum at 3 T and 7 T.NMR Biomed. 2015 Aug;28(8):976-87. 
  • Schmid S, Heijtel DF, Mutsaerts HJ, Boellaard R, Lammertsma AA, Nederveen AJ, van Osch MJ. Comparison of velocity- and acceleration-selective arterial spin labeling with [15O]H2O positron emission tomography. J Cereb Blood Flow Metab. 2015 2015 Aug;35(8):1296-303 
  • Ercan AE, Techawiboonwong A, Versluis MJ, Webb AG, Ronen I. Diffusion-weighted chemical shift imaging of human brain metabolites at 7T.Magn Reson Med. 2015 Jun;73(6):2053-61. doi: 10.1002/mrm.25346. Epub 2014 Jul 1.
  • Brink WM, van den Brink JS, Webb AG. The effect of high-permittivity pads on specific absorption rate in radiofrequency-shimmed dual-transmit cardiovascular magnetic resonance at 3T. J Cardiovasc Magn Reson. 2015 Sep 19;17:82.
  • Schmidt R, Webb A. A new approach for electrical properties estimation using a global integral equation and improvements using high permittivity materials. J Magn Reson. 2016 Jan;262:8-14. doi: 10.1016/j.jmr.2015.11.002. Epub 2015 Dec 1.

Contact

Andrew Webb, Professor
C.J.Gorter High Field Magnetic Resonance Center,
Department of Radiology - C3Q
Leiden University Medical Center
Albinusdreef 2, 2333 ZA Leiden
The Netherlands
Phone: +31-71-526-5483
Fax: +31-71-524-8256
Email: a.webb@lumc.nl