Heart in 3D

Medical Delta: Pieken in de Delta

Vikas Gupta, PhD student at LUMC and dept of Mediamatics, Delft University of Technology, v.guptaATlumc.nl
Hortense Kirisli, PhD student at BIGR, Erasmus Medical Center,  h.kirisliATerasmusmc.nl, and at LKEB, LUMC.
Rahil Shahzad, PhD student at the Quantitative Imaging group, Delft University of Technology and at BIGR, Erasmus Medical Center: R.ShahzadATtudelft.nl

Background

The "Heart in 3D" project is a collaboration of four biomedical imaging research groups at three universities (Delft University of Technology, Leiden University Medical Centre, Erasmus Medical Centre Rotterdam), as part of the Medical Delta program. One goal of the "Heart in 3D" project is to develop algorithms and software to connect three types of diagnostic information on cardiac function (the status of the coronary arteries, myocardial perfusion and ventricular function) from multi-modality imaging studies.

Goal

To develop novel algorithms and quantitative analysis tools for fusion of multi-modal cardiac imaging data to support diagnosis and disease staging in cardiovascular disease.

Methods

The project initially aims at developing a tool for relating CTA data to multimodal MR data.
Combining the data on coronary anatomy as acquired by cardiac CT angiography with indicators of myocardial viability derived from cardiac MRI would enable the fusion of 3D models of the coronaries and myocardium, and would facilitate integrated analysis and display. Spatial relationships should directly be established between diseased coronary artery segments and the myocardial regions with abnormal perfusion. This would enable the location of coronary stenoses and perfusion abnormalities to be visualized in 3D and facilitate studying the relation between plaques and their functional effects on myocardial perfusion. Consequently, it would be useful for the assessment of progression and regression of atherosclerosis, and may open new areas for diagnosis, prevention, and treatment of coronary atherosclerosis. Figure 1 shows an initial result of an integrated presentation of myocardial perfusion, coronary morphology and cardiac anatomy as developed in the project.

integrated visualization
Figure 1. integrated visualization of myocardial perfusion, coronary morphology and cardiac anatomy

Publications

Journal/Conference Papers

H.A. Kirisli, M. Schaap, S. Klein, L. Neefjes, A.C. Weustink, T. van Walsum and W.J. Niessen, Fully automatic cardiac segmentation from 3D CTA data: a multiatlas based approach, SPIE Medical Imaging 2010 , in press

Contact

B.P.F. Lelieveldt PhD
Division of Image Processing
Department of Radiology, 1-C2S
Leiden University Medical Center
P.O. Box 9600
2300 RC Leiden
The Netherlands
Tel. +31 (0)71 526 1130
Fax. +31 (0)71 526 6801
mailto: B.LelieveldtATlumc.nl