Lydiane Hirschler



  • Arterial spin labeling
  • Brain clearance (glymphatics)
  • High-field MRI
  • Sequence programming


Lydiane Hirschler studied Biomedical Engineering at the Grenoble Institute of Technology in France, including a semester at the KTH Royal Institute of Technology in Stockholm, Sweden. Subsequently, she was enrolled in a PhD program at the Grenoble Institute of Neuroscience in collaboration with Bruker Biospin. Her PhD topic focused on the development of Arterial Spin Labeling (ASL) on preclinical scanners. After completing her PhD, she joined the CJ Gorter center at the LUMC to work on ASL in the human brain at 7T and more recently on brain clearance mechanisms (glymphatics). 


C. Baligand*, L. Hirschler*, T.T.J. Veeger, L. Václavu, S.L. Franklin, M.J.P. van Osch and H.E. Kan. A Split-Label Design for Simultaneous Measurements of Perfusion in Distant Slices by Pulsed Arterial Spin Labeling. Magnetic Resonance in Medicine 2021. DOI: 10.1002/mrm.28879.
Z. Wei, J. Xu, L. Chen, L. Hirschler, E.L. Barbier, T. Li, P.C. Wong, H. Lu. Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study. NMR in Biomedicine 2021. DOI: 10.1002/nbm.4568.
L.P. Munting, M. Derieppe, E. Suidgeest, L. Hirschler, M.J.P. van Osch, B.D. de Senneville, L. van der Weerd. Cerebral Blood Flow and Cerebrovascular Reactivity are preserved in a Mouse Model of Cerebral Microvascular Amyloidosis. Elife 2021. DOI: 10.7554/eLife.61279.

B.P. Meyer, L. Hirschler, S. Lee, S.N. Kurpad, J.M. Warnking, E.L. Barbier, M.D. Budde. Optimized Cervical Spinal Cord Perfusion MRI after Traumatic Injury in the Rat. Journal of Cerebral Blood Flow and Metabolism 2021. DOI: 10.1177/0271678X20982396.
L. Petitclerc, S. Schmid, L. Hirschler, M.J.P. van Osch. Combining T2 measurements and crusher gradients into a single ASL sequence for comparison of the measurement of water transport across the blood-brain barrier. Magnetic Resonance in Medicine 2020. DOI: 10.1002/mrm.28613.

S.L. Franklin, I.K. Bones, A.A. Harteveld, L. Hirschler, M. van Stralen, Q. Qin, A. de Boer, H. Hoogduin, C. Bos, M.J.P. van Osch, S. Schmid. Multi-organ comparison of flow-based Arterial Spin Labeling techniques: spatially non-selective labeling for cerebral and renal perfusion imaging. Magnetic Resonance in Medicine 2020. DOI: 10.1002/mrm.28603.

P. Clement, T. Booth, F. Borovechi, K. E. Emblem, P. Figueiredo, L. Hirschler, R. Jancalek, V. C. Keil, C. Maumet, Y. Ozsunar, C. Pernet, J. Petr, J. Pinto, M. Smits, E. A.H. Warnert. “Cross-border collaborations to promote advanced MRI biomarkers in glioma”. Journal of Medical and Biological Engineering 2020. DOI: 10.1007/s40846-020-00582-z
L. Hirschler*, C. Debacker*, J. Voiron, S. Köhler, C. Wary, J.M. Warnking, and E.L. Barbier. Continuous Arterial Spin Labeling with a dedicated labeling coil. Bruker Application Note 2020. 
L. Hirschler, N. Collomb, J. Voiron, S. Köhler, EL. Barbier, JM. Warnking. SAR comparison between CASL and pCASL at high magnetic field and evaluation of the benefit of a dedicated labeling coil. Magn Reson Med. 2019; 00: 1– 8. DOI: 10.1002/mrm.27931
S. Yousefi, L. Hirschler, M. van der Plas, MS. Elmahdy, H. Sokooti, MJP. Van Osch, M. Staring. Fast Dynamic Perfusion and Angiography Reconstruction using an end-to-end 3D Convolutional Neural Network. 2019. Available from:
C. Adams, P. Bazzigaluppi, TL. Beckett, J. Bishay, I. Weisspapir, A. Dorr, JR. Mester, J. Steinman, L. Hirschler, JM Warnking, EL. Barbier, J. McLaurin, JG. Sled, B. Stefanovic. Neurogliovascular dysfunction in a model of repeated traumatic brain injury. Theranostics 2018; 8(17):4824-4836. doi:10.7150/thno.24747. Available from 

L. Hirschler*, L.P. Munting*, A. Khmelinskii, W.M. Teeuwisse, E. Suidgeest, J.M. Warnking, L. van der Weerd, E. L. Barbier, and M.J.P. van Osch. Transit time mapping in the mouse brain using time-encoded pCASL. NMR in Biomedicine 2017. DOI: 10.1002/nbm.3855.

L. Hirschler, C. Debacker, J. Voiron, S. Köhler, J.M. Warnking, and E.L. Barbier. Inter-Pulse Phase Corrections for Unbalanced Pseudo-Continuous Arterial Spin Labeling at High Magnetic Field. Magnetic Resonance in Medicine, 2017. DOI: 10.1002/mrm.26767.

L. Boisserand, B. Lemasson, L. Hirschler, A. Moisan, V. Hubert, E. L. Barbier, C. Rémy, O. Detante, Multiparametric MRI including oxygenation mapping of experimental ischaemic stroke. Journal of Cerebral Blood Flow & Metabolism. DOI: 2016:0271678X16662044.


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