Dr. Hermien E. Kan

Vakgebied(en)

  • MR spectroscopy
  • Neuromuscular diseases
  • Energy metabolism

Introductie

Hermien Kan has a background in Human Movement Sciences and performed her PhD studies in the MR spectroscopy group of Prof. Heerschap at the UMC st Radboud, where she applied multi-nuclear MR spectroscopy (31P, 1H and 13C) in the study of creatine related energy metabolism. After obtaining her PhD (April 2007), she started her studies in muscular dystrophy patients by performing MR imaging and 31P MRS in patients with facioscapulohumeral dystrophy, in collaboration with Prof. G. Padberg. In June 2008, she joined the C.J. Gorter Center for high field MRI, where her main focus is on high field muscle MR spectroscopy and MR imaging of muscle and brain in Duchenne and Becker muscular dystrophy. She was a member of the TREAT-NMD network of excellence MRI working group and is a member of the scientific advisory board of the Prinses Beatrix Spierfonds. Her current research is funded by grants from NWO - Vidi, the Gratama Stichting, the Duchenne Parent Project, the Associacion Francaise de Myology and the EU. She is workpackage leader on the FP7 EU project BIOIMAGE_NMD and the COST action: ' Applications of MR imaging and spectroscopy techniques in neuromuscular disease: collaboration on outcome measures and pattern recognition for diagnostics and therapy development'. In 2015, she was awarded a NWO Vidi grant. In this project, she will study why certain muscles are spared in muscular dystrophies.


Selected publications

For a full list click here

  1. Hooijmans MT, Doorenweerd N, Baligand C, Verschuuren JJGM, Ronen I, Niks EH, Webb AG, Kan HE. Spatially localized phosphorous metabolism of skeletal muscle in Duchenne muscular dystrophy patients: 24-month follow-up. PLoS One. 2017 Aug 1;12(8):e0182086

  2. Zielman R, Wijnen JP, Webb A, Onderwater GLJ, Ronen I, Ferrari MD, Kan HE, Terwindt GM, Kruit MC. Cortical glutamate in migraine. Brain. 2017 Jul 1;140(7):1859-1871

  3. Burakiewicz J, Sinclair CDJ, Fischer D, Walter GA, Kan HE, Hollingsworth KG. Quantifying fat replacement of muscle by quantitative MRI in muscular dystrophy. J Neurol. 2017 In press.

  4. Hooijmans MT, Niks EH, Burakiewicz J, Anastasopoulos CA, van den Berg SI, van Zwet E, Webb AG, Verschuuren JJ, Kan HE. Non-uniform muscle fat replacement along the proximodistal axis in Duchenne Muscular Dystrophy. Neuromusc Disord. In press.

  5. Duijnisveld BJ, Henseler JF, Reijnierse M, Fiocco M, Kan HE, Nelissen RG. Quantitative Dixon MRI sequences to relate muscle atrophy and fatty degeneration with range of motion and muscle force in brachial plexus injury. Magn Reson Imaging. 2017 Feb;36:98-104

  6. Wijnen JP, Klomp DW, Nabuurs CI, de Graaf RA, van Kalleveen IM, van der Kemp WJ, Luijten PR, Kruit MC, Webb A, Kan HE, Boer VO. Proton observed phosphorus editing (POPE) for in vivo detection of phospholipid metabolites. NMR in Biomed. 2016 Sep;29(9):1222-30

  7. van de Bank BL, Emir UA, Boer VO, van Asten JJA, Wijnen JP, Kan HE, Oz G, Klomp DWJ and Scheenen TWJ. Multi-center reproducibility of neurochemical profiles in the human brain at 7 Tesla. NMR in Biomed. 2015 Mar;28(3):306-16.

  8. Wokke BH, Hooijmans MT, van den Bergen JC, Webb AG, Verschuuren JJ, Kan HE. Muscle MR spectroscopy detects elevated PDE/ATP ratios prior to fatty infiltration in Becker muscular dystrophy. NMR Biomed. 2014 Nov;27(11):1371-7

  9. Doorenweerd N, Straathof CS, Dumas EM, Spitali P, Ginjaar IB, Wokke BH, Schrans DG, van den Bergen JC, van Zwet EW, Webb A, van Buchem MA, Verschuuren JJ, Hendriksen JG, Niks EH, Kan HE. Reduced cerebral gray matter and altered white matter in boys with Duchenne muscular dystrophy. Ann Neurol 2014, Sep;76(3):403-11

  10. Wokke BH, van den Bergen JC, Versluis MJ, Niks EH, Milles J, Webb AG, van Zwet EW, Aartsma-Rus A, Verschuuren JJ, Kan HE. Quantitative MRI and strength measurements in the assessment of muscle quality in Duchenne muscular dystrophy. Neuromuscul Disord. 2014; May; 24(5):409-16

  11. Hu HH, Kan HE. Quantitative proton MR techniques for measuring fat. NMR Biomed  2013 Dec;26(12):1609-29.

  12. van Oorschot JW, Schmitz JP, Webb A, Nicolay K, Jeneson JA, Kan HE. 31P MR Spectroscopy and Computational Modeling Identify a Direct Relation between Pi Content of an Alkaline Compartment in Resting Muscle and Phosphocreatine Resynthesis Kinetics in Active Muscle in Humans. PLoS ONE 2013;Sep 30;8(9):e76628.

  13. Branzoli F, Techawiboonwong A, Kan HE, Webb A, Ronen I. Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T. Magn Reson Med. 2013 Feb;69(2):303-9. 

  14. Wokke BH, Bos C, Reijnierse M, van Rijswijk CS, Eggers H, Webb A, Verschuuren JJ,  Kan HE. Comparison of dixon and T1-weighted MR methods to assess the degree of fat infiltration in duchenne muscular dystrophy patients. J Magn Reson Imaging 2013 Sep;38(3):619-24.

  15. Kan HE, Klomp DWJ, Wong CS, Boer VO, Webb AG, Luijten PR and Jeneson JA. In vivo 31P MRS detection of an alkaline inorganic phosphate pool with short T1 in human resting skeletal muscle. NMR in Biomed 2010; 23(8):995-1000 

  16. Kan HE, Scheenen TWJ, Wohlgemuth M, Klomp DWJ, van Loosbroek-Wagemans I, Padberg GW, Heerschap A. Quantitative MR imaging of individual muscle involvement in facioscapulohumeral muscular dystrophy. Neuromuscul Disord. 2009; 19(5):357-62.



Book chapters

1.     Badrising UA, Kan HE, and Verschuuren, JJGM. MRI in Inflammatory Myopathies and Autoimmune-Mediated Myositis.   Medical Radiology 2013

2.     Kan HE, Janssen BJ and Voet N. Facioscapulohumeral dystrophy. In: Neuromuscular imaging, Edited by Fischer D and Wattjes MP. Springer. 2013

3.     Heerschap A., Nabuurs CIHC, Kan HE, Wieringa B, Isbrandt D. Measurements of brain creatine metabolism in vivo: magnetic resonance spectroscopy studies of transgenic animals. In : Advances in Neurobiology, Neural metabolism in vivo, edited by Choi, I. Springer. 2012

4.     Heerschap A, Kan HE, Nabuurs CIHC, Renema WKJ, Isbrandt D,  Wieringa B. In vivomagnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes. Subcell. Biochem. 46, Edited by Salomons GS and Wyss M., 2007


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1
Kamer J0-35

Albinusdreef 2
2333 ZA Leiden
Tel: +31 71 526 6097

Postzone C3Q
Postbus 9600
2300 RC Leiden

E-mail: h.e.kan@lumc.nl