Early arthritis - CTMM –TRACER

Dr. M. Reijnierse, Prof dr. J.L. Bloem


Since new effective medication (TNF blocking agents) is available, early detection of rheumatoid arthritis (RA) is of increasing importance. The additional application of MRI in the rheumatology outpatient clinic (Early arthritis Clinic-EAC) leads to the opportunity to integrate imaging modalities in clinical practice and to evaluate the additional value of MRI. Early detection of RA and insight in response to therapy in established RA, will lead to personalized medicine, a major goal in the treatment of RA patients.

In this project the 1.5 T dedicated extremity MR scanner is used in daily practice, while the 3T whole body system and 7T MRI system are used as molecular based imaging technologies for early detection and characterization of RA.

Study populations

All patients visiting the Early Arthritis Clinic of the LUMC are eligible for this study. The ERA-cohort consists of patients with early arthritis, undifferentiated as well as rheumatoid arthritis: based on several well-characterized cohorts with a large sample size. LUMC has started since 1993 a cohort in which all patients with recent onset inflammatory arthritis (early arthritis) enter.

Collaborative networks

  • This study is funded by the Center for Translational Molecular Medicine (CTMM).
  • Project title: Development of Tools (and prediction rules) to time and select therapy in treatment of pre-clinical, early and established Rheumatoid Arthritis: Creating Enhanced Remedy. Project acronym: TRACER
  • Department of Rheumatology: Dr. A.H.M. van der Helm- van Mil, Prof dr.T.W.J. Huizinga
  • C. J. Gorter Center for High-Field MRI: Prof dr. A. Webb
  • Personalized Medicine in RA

Volunteers Wanted!

The departments of rheumatology and radiology are  developing a MRI-atlas of normal hands and feet; do you participate?

dutch version below.

Within the rheumatologic field there is a large focus on early recognition of (rheumatoid) arthritis, as this allows early start of treatment. resulting in better disease outcome.

Within the LUMC the departments of rheumatology and radiology collaborate on a  research project that aims to determine the diagnostic value of extremity MRI in the earliest phases of the disease.

To differentiate disease from the healthy situation, we are making a reference atlas of normal variants. In total we plan to make MRIs of hands and feet of 200 healthy persons. Although the project is running well, it appears to be very difficult to include persons aged 40-50 years and persons aged >70 years.

Do  you have no symptoms of your hands and feet and you are ages 40-50?  You would help us very much when you could participate!

Mail or call Lukas Mangnus for more information (atlas@LUMC.nl, 071-5297420)

We maken een MRI - atlas van normale handen en voeten. Doe je mee?

Het reumatologisch veld richt zich op vroeg-herkenning van (reumatoïde) artritis en binnen het LUMC onderzoeken de afdelingen reumatologie en radiologie tesamen of MRI hier van waarde is.

Om te weten wat ziek is, willen we eerst bepalen welke variaties normaal zijn en deze normale scans bundelen in een referentie atlas.

Om onze atlas compleet te maken zijn we hard op zoek naar mensen die tussen de 40 en 50 jaar oud zijn en geen klachten van handen en voeten hebben.

Voldoe je aan deze beschrijving? Het zou ons enorm helpen als je mee wilt doen! Mail of bel voor informatie naar Lukas Mangnus (atlas@LUMC.nl, l 071-5297420).