Detection and Quantification of Early Ischemic Changes in Stroke

Graduation project in collabration with Academic Medical Centre (Amsterdam) and the University of Twente (Enschede).

Floor van Rijn
Berend Stoel
Marius Staring


In patients with ischemic stroke, a cerebral artery is occluded and a core of brain tissue dies rapidly. When a patient with symptoms of acute ischemic stroke is brought to the ER, first a non-contrast computed tomography (NCCT) is performed. Based on this scan, thrombolytic treatment is decided, to dissolve the blockage of the artery, which is of utmost importance in successful treatment of the acute ischemic infarct.

Early ischemic changes (EICs) on NCCT are an indication of stroke. However the detection of EICs is difficult and time consuming, even by experienced radiologists. Hence, stroke severity and risks remain uncertain.


Therefore the aim of our research is to develop a densitometric tool for calculating the Alberta Stroke Program Early CT Score (ASPECTS); a scoring method used by clinicians to assess the severity of acute ischemic stroke. This software tool gives potentially a reproducible, easy, fast and quantitative indicator of stroke, and could give us the possibility to search for a patient specific treatment.

 ASPECTS regions




Berend Stoel, PhD
Division of Image Processing
Department of Radiology, 1-C2S
Leiden University Medical Center
P.O. Box 9600
2300 RC Leiden
The Netherlands
phone: +31 (0)71 526 1911