Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome wide correlation of gene expression in the mouse brain (from the Allen Mouse Brain Atlas) to discover 1) brain regions that respond in a similar manner to particular steroids, 2) signaling pathways that are used in a steroid receptor and brain region-specific manner, and 3) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support new insights in neuroendocrine relationships, and to develop novel ways to manipulate brain activity in research of clinical settings.
- Ahmed Mahfouz
- Boudewijn P.F. Lelieveldt
- Lisa T.C.M. van Weert (Endocrinology)
- Marcel J.T. Reinders (TU Delft)
- Onno C. Meijer (Endocrinology)
- A. Mahfouz, B.P.F. Lelieveldt, A. Grefhorst, L.T.C.M. van Weert, I.M. Mol, H.C.M. Sips, J.K. van den Heuvel, N.A. Datson, J.A. Visser, M.J.T. Reinders, O.C. Meijer, “Genome-wide co-expression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions”, Proceedings North American Academy of Sciences doi:10.1073/pnas.1520376113, 2016