Musculoskeletal

Director: Prof. dr. J.L. Bloem
Section head: Dr. M. Reijnierse

Focus

Musculoskeletal research is embedded in the clinical unit of musculoskeletal imaging (section head M. Reijnierse, MD) and is focused on musculoskeletal tumors, and inflammatory and degenerative disorders of the musculoskeletal system. Within these clinical imaging themes our endeavors are geared towards unraveling pathophysiology, monitoring effectiveness of therapy, increasing cost-effectiveness of imaging, and developing new technical approaches in data acquisition and post processing.

To this end we closely collaborate with other clinical and scientific groups within our department and within the LUMC.

Diagnosis and image guided minimally invasive treatment of musculoskeletal neoplasms and tumor-like lesions have been main research topics for many years in close collaboration with the Leiden based Netherlands Committee on Bone Tumors. Research on the topic of joint disease is focused on the early detection of disease in rheumatoid arthritis and spondyloarthritis as well as the assessment of degenerative joint disease (osteoarthritis).

We aim to image disease processes with the use of state-of-the-art imaging, focused on MRI, including the use of 7T MR imaging (Prof A. Webb). Data post-processing and quantification (Division of Medical Image Processing-LKEB, Prof B.P.F. Lelieveldt) is of increasing importance in this high technology field. The cost-effective use of MR imaging is of ongoing interest.

Research themes of the musculoskeletal imaging group

  1. Diseases
    1. Musculoskeletal tumors

      Image analysis for whole-body MR imaging-STW project
      Ir. R.J. van der Geest, Prof dr. B.P.F. Lelieveldt, Dr. M. Reijnierse, Prof. Dr. JL Bloem.
    2. Inflammatory and joint diseases
      1. Spondyloarthritis - SPACE
      2. Early arthritis - CTMM –TRACER
      3. Osteoarthritis-CHECK
      4. Rheumatoid arthritis developing parameters for treatment monitoring
      5. Subacromial Impingement Syndrome-SISTIM and Rotator cuff calcific tendinitis. A. Navas Canete, Dr. M. Reijnierse, Prof. Dr. JL Bloem
      6. Cost-effectiveness of MRI of the knee: TACLE_trial
      7. Hip dysplasia and ultrasound; A. Navas Canete
      8. Femoroacetabular impingement; Reijnierse

    3. Other projects
      1. M. Duchenne
        Dr. H. E. Kan, Dr. M. Reijnierse, Dr. C.S.P. van Rijswijk

  2. Technological research lines
    1. MR hardware (Webb)
    2. MR techniques (Geleijns, de Bruijn)
    3. Post-processing (Lelieveldt, Stoel)

Embedding

  1. LUMC
    Our program fits in two of the 9 research themes of the LUMC
    Biomedical imaging
    Autoimmunity
  2. Leiden University
    Our program fits in two of the 11 research profile areas of Leiden University
    Health prevention and human life cycle
    Bioscience
  3. National embedding
    Our group is embedded in the Medical Delta initiative.
    On a technological level, our group closely collaborates with Philips Healthcare and General Electric for MR techniques and Toshiba Medical Systems for CT techniques with respect to development, application and validation of new imaging techniques for the musculoskeletal system. Together with the Division of Medical Image Processing (LKEB) there is a close cooperation with Technical University Delft, the Netherlands.