Dr. ir. Sophie Schmid


  • Arterial spin labeling
  • Brain perfusion imaging
  • Cerebrovascular reactivity
  • Hereditary Cerebral Hemorrhage With Amyloidosis - Dutch type (HCHWA-d, Katwijkse ziekte)
  • Cerebral amyloid angiopathy (CAA)


In February 2011, she started her PhD research at the CJ Gorter Center for high field MRI of the Leiden University Medical Center. Her main research topics are the development and optimization of arterial spin labeling (ASL) perfusion techniques, like acceleration selective ASL (AccASL), time encoded pseudo continuous ASL (te-pCASL) and new oxygen extraction fraction measurement techniques, that enable the detection and characterization of small vessel disease.

Since February 2015 she is studying the cerebrovacular reactivity in Hereditary Cerebral Hemorrhage With Amyloidosis – Dutch type (HCHWA-d), also known as the Katwijk disease, a hereditary form of cerebral amyloid angiopathy (CAA). The vessels in the brain are challenged with CO2 and visual stimulation at 3T MRI and compared between patients with HCHWA-d and age and gender matched healthy controls to get insight in the effect of the amyloid deposition in the cerebrovascularture and the reactivity of the vessels. This study is part of the CAVIA project, which has been made possible by ZonMW, part of the Dutch national 'Deltaplan for Dementia'.

Currently she is working on developing a new ASL technique to selectively label the venous blood pool in the brain for oxygen extraction fraction measurements.  


For a full list, click here 
  1. Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow, Matthias JP van Osch, Wouter M Teeuwisse, Zhensen Chen, Yuriko Suzuki, Michael Helle, Sophie Schmid, Journal of Cerebral Blood Flow & Metabolism, 2018: 38(9), 1461-1480

  2. Insight into the labeling mechanism of Acceleration selective arterial spin labeling, S Schmid, ET Petersen, and MJP van Osch, Magnetic resonance materials in physics, biology and medicine, 2016: 30(2), 165-174

  3. Time-efficient determination of spin compartments by time-encoded pCASL T 2-relaxation-under-spin-tagging and its application in hemodynamic characterization of the cerebral border zones,S Schmid, WM Teeuwisse, H Lu and MJP van Osch, NeuroImage, 2015; 123, 72-79

  4. Comparison of velocity-and acceleration-selective arterial spin labeling with 15O-H2O positron emission tomography,S Schmid, DFR Heijtel, HJMM Mutsaerts, R Boellaard, AA Lammertsma, AJ Nederveen and MJP van Osch, Journal of Cerebral Blood Flow & Metabolism, 2015; 35(8), 1296-1303

  5. Acceleration-selective arterial spin labeling, S Schmid, E Ghariq, WM Teeuwisse, A Webb and MJP van Osch, Magnetic resonance in medicine, 2014; 71(1): 191-199


Leids Universitair Medisch Centrum
Gebouw 1
Kamer J0-209,

Albinusdreef 2
2333 ZA Leiden
Tel: 071 526 5608

Postzone C3Q,
Postbus 9600
2300 RC Leiden

E-mail: s.schmid@lumc.nl