Dr. Chloe Najac

Post-doctoral fellow

Vakgebied(en)

  • MR spectroscopy of the brain
  • Cellular metabolism
  • Tissue microstructure

Introductie

Chloé completed her PhD in 2014 under the supervision of Drs. Julien Valette and Vincent Lebon at the Molecular Imaging Research Centre in Paris. During her PhD, she developed novel MR tools to assess brain tissue microstructure using diffusion-weighted MR spectroscopy and cellular metabolism using direct MR detection of 17O metabolism, the only MR-visible oxygen nuclei. After graduating, she joined as a post-doctoral fellow the Department of Radiology and Biomedical Imaging at the University of California in San Francisco, where she studied brain tumor metabolism using hyperpolarized 13C MR spectroscopy in the group of Pr. Sabrina Ronen. Mid-august 2018, Chloé joined the C.J. Gorter Center for high field MRI as a post-doctoral fellow. Under the guidance of Drs. Hermien Kan and Itamar Ronen, she continues her work on developing MR spectroscopy based methods to study the brain. Her main focus is to investigate brain microstructure, function and biochemistry in healthy and pathological conditions.    

  


Key publications

For a full list, click here

[1] Najac C., Chaumeil M.M., Kohanbash G., Guglielmetti C., Gordon J.W., Okada H., Ronen S.M. Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine. Scientific reports. 2016;6:31397.

[2] Najac C., Branzoli F., Ronen I., Valette J. Brain intracellular metabolites are freely diffusing along cell fibers in grey and white matters, as measured by diffusion-weighted MR spectroscopy in the Human brain at 7 T. Brain. Structure and Function. 2016;221(3):1245-54. 

[3] Najac C., Ronen S.M. MR Molecular Imaging of Brain Cancer Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy. Topics in Magnetic Resonance Imaging. 2016;25(5):187-196. 

[4] Chaumeil M.M., Najac C., Ronen S.M. Studies of metabolism using (13)C MRS of hyperpolarized probes. Methods in Enzymology. 2015;561:1-71.

[5] Najac C., Marchadour C., Guillermier M., Houitte D., Slavov V., Brouillet E., Hantraye P., Lebon V., Valette J. Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy. NeuroImage. 2014;90:374-380.


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden

Postbus 9600
2300 RC Leiden