- Tumor Immunology
- (Immunogenic) Chemotherapy
- Nanomedicine (PLGA nanoparticles)
- Tumor microenvironment immune modulation
- Therapeutic cancer vaccines
Candido obtained his Master’s degree in Oncology in 2013 at the Medical Faculty of VUmc Amsterdam. In 2014 he started as a PhD-student at the group Translational Nanobiomaterials and Imaging (TNI), Radiology department, at Leiden University Medical Center (LUMC). His PhD-project entails the research on nano-vehicles as a platform for tracking and immunochemotherapy of cancer. The main objective of his project is to perform research on how to induce or improve the body’s own immune system responses against cancer cells by employing cutting-edge nanotechnology, with a particular focus in tumor microenvironment immune modulation.
Besides performing research for his PhD-project, Candido is also enrolled into a four year postgraduate SMBWO educational trajectory to become a certified Immunologist. Furthermore, he is an enthusiastic member of the Dutch Society for Immunology (NVVI) and a board member of Leids Promovendi Overleg (LEO) Leiden PhD Association.
Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles
Candido G da Silva, M.G. Camps, T.M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ossendorp F, Luis J. Cruz
Theranostics 2019; 9(22):6485-6500. doi:10.7150/thno.34429
Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines
Candido G da Silva, M.G. Camps, T.M.W.Y. Li, A.B. Chan, Ossendorp F, Luis J. Cruz
Riding the techwave in an era of change - The healthcare guide to the future
J. ten Berge, J. Blok, Constantino Garcia Maldonado, Esther Heckendorf, Stephanie Holst-Bernal, Malou Noten, CG Da Silva, Klodiana-Daphne Tona, D. Truijens and Eleonoor Verlinden
Stichting Maatschappij en Onderneming 08-08-2018
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences
Chih Kit Chung, CG Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J Cruz
Journal of Controlled Release 285 (2018) 56-66
The potential of multi-compound nanoparticles to bypass drug resistance in cancer
Candido G. da Silva, Godefridus J Peters, Ossendorp F, Luis J Cruz.
Cancer Chemother Pharmacol. 2017 Sep 8.
The Potential of Nano-Vehicle Mediated Therapy in Vasculitis and Multiple Sclerosis
Ruben V. Huis in `t Veld, Candido G. da Silva, Eric L. Kaijzel, Alan B. Chan and Luis J Cruz.
Curr Pharm Des. 2016 Dec 21.
Conference Paper: Synergistic combination of immune modulating nanoparticles with a therapeutic cancer vaccine efficiently eradicates established tumors
Candido G da Silva, M.G. Camps, T.M.W.Y. Li, Löwik CW, Ossendorp F, Luis J. Cruz
BSI/NVVI Congress 2016, Arena Conference Centre in Liverpool, UK
Combinatorial Prospects Of Nano-Targeted Chemoimmunotherapy
Da Silva CG, Rueda F, Löwik CW, Ossendorp F, Cruz LJ.
Biomaterials. 2016 Mar;
Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters
Candido G Da Silva, Richard J Honeywell, Henk Dekker, Godefridus J Peters
Expert Opin Drug Metab Toxicol. 2015 May
Conference Paper: In situ antitumor immunomodulation and immunogenic chemotherapy delivery using PLGA nanoparticles
Candido G da Silva, Clemens W G M Löwik, Ferry Ossendorp, Luis Javier Cruz
CHAINS Congress 2014, Veldhoven, The Netherlands
C-Met signaling and preclinical analysis of Crizotinib in uveal melanoma
PA van der Velden, M de Lange, CG da Silva, M Versluis, GPM Luyten, MJ Jager
Acta Ophthalmologica 89 (s248), 0-0, 2011. 2, 2011
Conferences, Talks and Posters
Leids Universitair Medisch Centrum
2333 ZA Leiden
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2300 RC Leiden