Drs. C. da Silva

Researcher, PhD-candidate, Immunologist (io; smbwo)


  • Oncology
  • Immunology
  • Tumor Immunology
  • Immunotherapy
  • (Immunogenic) Chemotherapy
  • Nanomedicine (PLGA nanoparticles)
  • Tumor microenvironment immune modulation
  • Therapeutic cancer vaccines


Candido obtained his Master’s degree in Oncology in 2013 at the Medical Faculty of VUmc Amsterdam. In 2014 he started as a PhD-student at the group Translational Nanobiomaterials and Imaging (TNI), Radiology department, at Leiden University Medical Center (LUMC). His PhD-project entails the research on nano-vehicles as a platform for tracking and immunochemotherapy of cancer. The main objective of his project is to perform research on how to induce or improve the body’s own immune system responses against cancer cells by employing cutting-edge nanotechnology, with a particular focus in tumor microenvironment immune modulation.

Besides performing research for his PhD-project, Candido is also enrolled into a four year postgraduate SMBWO educational trajectory to become a certified Immunologist. Furthermore, he is an enthusiastic member of the Dutch Society for Immunology (NVVI) and a board member of Leids Promovendi Overleg (LEO) Leiden PhD Association.


Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

Candido G da Silva, M.G. Camps, T.M.W.Y. Li, Luana Zerrillo, Clemens W. Löwik, Ossendorp F, Luis J. Cruz

Theranostics 2019; 9(22):6485-6500. doi:10.7150/thno.34429


Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines

Candido G da Silva, M.G. Camps, T.M.W.Y. Li, A.B. Chan, Ossendorp F, Luis J. Cruz

Biomaterials, https://doi.org/10.1016/j.biomaterials.2019.119417


Riding the techwave in an era of change - The healthcare guide to the future

J. ten Berge, J. Blok, Constantino Garcia Maldonado, Esther Heckendorf, Stephanie Holst-Bernal, Malou Noten, CG Da Silva, Klodiana-Daphne Tona, D. Truijens and Eleonoor Verlinden

Stichting Maatschappij en Onderneming 08-08-2018

ISBN 978-90-6962-270-5


Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences

Chih Kit Chung, CG Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J Cruz

Journal of Controlled Release 285 (2018) 56-66


The potential of multi-compound nanoparticles to bypass drug resistance in cancer

Candido G. da Silva, Godefridus J Peters, Ossendorp F, Luis J Cruz.

Cancer Chemother Pharmacol. 2017 Sep 8.


The Potential of Nano-Vehicle Mediated Therapy in Vasculitis and Multiple Sclerosis

Ruben V. Huis in `t Veld, Candido G. da Silva, Eric L. Kaijzel, Alan B. Chan and Luis J Cruz.

Curr Pharm Des. 2016 Dec 21.


Conference Paper: Synergistic combination of immune modulating nanoparticles with a therapeutic cancer vaccine efficiently eradicates established tumors

Candido G da Silva, M.G. Camps, T.M.W.Y. Li, Löwik CW, Ossendorp F, Luis J. Cruz

BSI/NVVI Congress 2016, Arena Conference Centre in Liverpool, UK


Combinatorial Prospects Of Nano-Targeted Chemoimmunotherapy

Da Silva CG, Rueda F, Löwik CW, Ossendorp F, Cruz LJ.

Biomaterials. 2016 Mar;


Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters

Candido G Da Silva, Richard J Honeywell, Henk Dekker, Godefridus J Peters

Expert Opin Drug Metab Toxicol. 2015 May


Conference Paper: In situ antitumor immunomodulation and immunogenic chemotherapy delivery using PLGA nanoparticles

Candido G da Silva, Clemens W G M Löwik, Ferry Ossendorp, Luis Javier Cruz

 CHAINS Congress 2014, Veldhoven, The Netherlands


C-Met signaling and preclinical analysis of Crizotinib in uveal melanoma

PA van der Velden, M de Lange, CG da Silva, M Versluis, GPM Luyten, MJ Jager

Acta Ophthalmologica 89 (s248), 0-0, 2011. 2, 2011

Conferences, Talks and Posters

Dutch Society for Immunology (N.V.V.I.)
December 13-14, 2017, Noordwijkerhout, The Netherlands
CHAINS 2017: Chemistry for the Future
December 5-7, 2017, Veldhoven, The Netherlands 
PEGS Europe - Oncology & Therapeutics
November 13-17, 2017, Lisbon, Portugal 
Immunopharmacology Conference 2017
Talk, June 25-29, 2017, in Varadero Beach, Cuba.

Innovation For Health 2017 Conference
Poster, February 2017 in Rotterdam, The Netherlands 
British and Dutch Societies for Immunology BSI/NVVI
December 2016 in Liverpool, United Kingdom
Talk, 11:45 Innovative Strategies of Immunotherapy of Cancer (Part 1)
CHAINS 2014, At Veldhoven, The Netherlands
Poster, November 2014 in Veldhoven, The Netherlands


Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden
Tel: +31 71 5161848

Postzone C2-S
Postbus 9600
2300 RC Leiden

E-mail: C.da_Silva@lumc.nl