Jouke Dijkstra, PhD

Associate professor

Area(s) of interest

  • IntraVascular Ultrasound (IVUS).
  • Optical Coherence Tomography (OCT).
  • Vascular image analysis (Computed Tomography Angiography).
  • Analysis, registration and visualization of multi-model molecular images.
  • Image guided surgery.


Dr, Dijkstra is associate Professor at LUMC-LKEB, where he is the leader of the "vascular and molecular imaging" section. He has been working at the division of image processing since 1996 and is responsible for the research in vessel imaging, in particular IntraVascular UltraSound, Optical Coherence Tomography and Computed Tomographic Angiography. The research resulted in several scientific publications and analytical software packages, which have been transferred to the industry and are used world wide. These packages are still being expanded with new functionality. Several grants from STW and the Ministry of Economical affairs have been approved for this research, like the current project on risk assessment if cardiovascular diseases from Computed Tomographic Angiographic images.

Furthermore he is responsible for the molecular imaging post-processing research including image guided surgery. Molecular imaging related projects currently under his supervision are the CYTTRON I and II project which is a Dutch government sponsored project about imaging from molecular through the cellular level and he is co-Principle Investigator of the CTMM – MUSIS project. MUSIS is a government sponsored projects about the development of methods for image guided surgery, both open en endoscopic surgery using multispectral imaging and fluorescent cancer targeting probes for better tumor resection.

The focus of the section is the development of quantitative software for image and signal processing algorithms for biomedical image processing.

Key Publications

  1. Sven D Mieog J, Vahrmeijer AL, Hutteman M, van der Vorst JR, Drijfhout van Hooff M, Dijkstra J, Kuppen PJ, Keijzer R, Kaijzel EL, Que I, van de Velde CJ, Löwik CW. Novel intraoperative near-infrared fluorescence camera system for optical image-guided cancer surgery. Mol Imaging. 2010 Aug;9(4):223-31.
  2. Mieog, J.S.D., Hutteman, M., van der Vorst, J.R., Kuppen, P.J.K., Que, I., Dijkstra, J., Kaijzel, E.L., Prins, F., Löwik, C.W.G.M., Smit, V.T.H.B.M., van de Velde, C.J.H., Vahrmeijer, A.L. Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer (2010) Breast Cancer Research and Treatment, pp. 1-11.
  3. Kok P, Baiker M, Hendriks EA, Post FH, Dijkstra J, Löwik CW, Lelieveldt BP, Botha CP. Articulated planar reformation for change visualization in small animal imaging. IEEE Trans Vis Comput Graph. 2010 Nov-Dec;16(6):1396-404.
  4. Okamura T, Gonzalo N, Gutiérrez-Chico JL, Serruys PW, Bruining N, de Winter S, Dijkstra J, Commossaris KH, van Geuns RJ, van Soest G, Ligthart J, Regar E. Reproducibility of coronary Fourier domain optical coherence tomography: quantitative analysis of in vivo stented coronary arteries using three different software packages. EuroIntervention. 2010 Aug;6(3):371-9.
  5. Boogers MJ, Schuijf JD, Kitslaar PH, van Werkhoven JM, de Graaf FR, Boersma E, van Velzen JE, Dijkstra J, Adame IM, Kroft LJ, de Roos A, Schreur JH, Heijenbrok MW, Jukema JW, Reiber JH, Bax JJ. Automated quantification of stenosis severity on 64-slice CT: a comparison with quantitative coronary angiography. JACC Cardiovasc Imaging. 2010 Jul;3(7):699-709.
  6. Kaijzel E, van Heijningen P, Wielopolski P, Vermeij M, Koning G, van Cappellen WA, Que I, Chan A, Dijkstra J, Ramnath N, Hawinkels L, Bernsen M, Löwik C, Essers J. Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice. Circ Cardiovasc Imaging. 2010 Jun 30.
  7. Baiker M, Milles J, Dijkstra J, Henning TD, Weber AW, Que I, Kaijzel EL, Löwik CW, Reiber JH, Lelieveldt BP. Atlas-based whole-body segmentation of mice from low-contrast Micro-CT data. Med Image Anal. 2010 Dec;14(6):723-37.
  8. Bergheanu SC, Van der Hoeven BL, Hassan AK, Dijkstra J, Rosendaal FR, Liem SS, Schalij MJ, Van der Bom JG, Jukema JW. Post-intervention IVUS is not predictive for very late in-stent thrombosis in drug-eluting stents. Acta Cardiol. 2009 Oct;64(5):611-6.
  9. van der Giessen AG, Schaap M, Gijsen FJ, Groen HC, van Walsum T, Mollet NR, Dijkstra J, van de Vosse FN, Niessen WJ, de Feyter PJ, van der Steen AF, Wentzel JJ. 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis: a feasibility study. Int J Cardiovasc Imaging. 2009 Nov 28.
  10. Muskulus M, Scheenstra AE, Braakman N, Dijkstra J, Verduyn-Lunel S, Alia A, de Groot HJ, Reiber JH. Prospects for early detection of Alzheimer's disease from serial MR images in transgenic mice. Curr Alzheimer Res. 2009 Dec;6(6):503-18. Review.
  11. Scheenstra AE, Muskulus M, Staring M, van den Maagdenberg AM, Lunel SV, Reiber JH, van der Weerd L, Dijkstra J. The 3D Moore-Rayleigh test for the quantitative groupwise comparison of MR brain images. Inf Process Med Imaging. 2009;21:564-75.
  12. Schuurbiers JC, Lopez NG, Ligthart J, Gijsen FJ, Dijkstra J, Serruys PW, Van der Steen AF, Wentzel JJ. In vivo validation of CAAS QCA-3D coronary reconstruction using fusion of angiography and intravascular ultrasound (ANGUS). Catheter Cardiovasc Interv. 2009 Apr 1;73(5):620-6.
  13. Liefaard LC, Ploeger BA, Molthoff CF, de Jong HW, Dijkstra J, van der Weerd L, Lammertsma AA, Danhof M, Voskuyl RA. Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C] flumazenil and positron emission tomography. Epilepsia. 2009 Jan;50(1):88-98. Epub 2008 Aug 25.
  14. Bovenkamp EG, Dijkstra J, Bosch JG, Reiber JH. User-agent cooperation in multiagent IVUS image segmentation. IEEE Trans Med Imaging. 2009 Jan;28(1):94-105.
  15. Scheenstra AE, van de Ven RC, van der Weerd L, van den Maagdenberg AM, Dijkstra J, Reiber JH. Automated segmentation of in vivo and ex vivo mouse brain magnetic resonance images. Mol Imaging. 2009 Jan-Feb;8(1):35-44.
  16. Li, R., Emmerich, M.T., Eggermont, J., Bovenkamp, E.G., Bäck, T., Dijkstra, J., Reiber, J.H. Optimizing a medical image analysis system using mixed-integer evolution strategies (2009) Studies in Computational Intelligence, 213, pp. 91-112.


Leiden University Medical Center
Building 1
Room C3-56

Albinusdreef 2
2333 ZA Leiden
Tel: +31 (0)71 5262270

Postalzone C2-S
P.O. Box 9600
2300 RC Leiden
The Netherlands