- Cardiovascular MRI
- 4D Flow MRI
- Cardiovascular Imaging Processing
- Aortic Dissection and Aneurysm
Joe studied Biomedical Engineering (MSc., 2014-2017) and Industrial Design Engineering (BSc, 2010-2013) at the Delft University of Technology. During his graduation at the LUMC, he developed an intrauterine simulation tool to assess the operational workspace performances of fetoscopic laser photocoagulation instruments in twin-to-twin transfusion syndrome gestations. In March 2018 he started a PhD research at the CardioVascular Imaging Group of the LUMC.
An aortic aneurysm is life-threatening as it can lead to dissection and rupture. Aneurysms often remain undetected until a fatal event occurs. There are marked sex differences in incidence and mortality from aortic aneurysm. Current clinical guidelines recommend serial lumen assessment to monitor aneurysm growth. However, this approach suffers from low sensitivity and specificity to detect asymptomatic aortic aneurysm. There is an urgent clinical need for new biomarkers that go beyond lumen assessment and contribute to earlier aneurysm detection, preferably before growth, to prevent dissection and fatal rupture.
The aim of Joe's research is to develop a comprehensive clinically applicable aorta MRI protocol from which various quantitative anatomical, mechanical, structural and hemodynamic biomarkers can be assessed. Besides, an imaging analysis platform will be developed to establish physiological normal values and pathological abnormal cut-off values for these quantitative biomarkers. Eventually, the MRI protocol and imaging analysis platform will be used to developed a new screening programme for (a)symptomatic patients, with or without hereditary predisposition.
Leids Universitair Medisch Centrum
2333 ZA Leiden
Tel: +31 71 526 22 33
2300 RC Leiden