Dr. Irene Hernández Girón

Post-doctoraal onderzoeker


  • Medical imaging and medical physics
  • Computed Tomography
  • Artificial intelligence
  • 3D printing
  • Anthropomorphic phantoms design
  • Human and computer perception
  • Quality control and standardization in Computed Tomography
  • Objective clinical image quality assessment: Model observers


Dr. Irene Hernandez-Giron is a medical imaging researcher at the Division of Image Processing, working on advanced methods for image quality assessment combining 3D printing anthropomorphic phantoms and objective image quality metrics, such as model observers. In 2020, she started a Veni grant, awarded by NOW: "Through the eyes of AI: safe and optimal integration of Artificial Intelligence in Radiology"


She is investigating the change of paradigm with the introduction of AI for diagnostic medical applications in Radiology. So far, the imaging chain optimization is anthropocentric. A model shift will occurr once "computer" eyes start analyzing and scoring the images alongside radiologists. After working for years in assessing image quality in Radiology tuned to human perception, Irene investigates how AI “sees” the medical images and how to optimize the imaging chain for these new observers.

Irene obtained her MsC at the Universidad Complutense de Madrid (UCM, Spain) with a study of patient imparted doses in cardiac/CT (2008). She worked at Universidad Rovira I Virgili (URV, Spain) between 2010-2015 as a part-time teacher and researcher, besides her PhD studies. Her PhD (2016) versed about “Model observers applied to low contrast detectability assessment in Computed Tomography”. Between 2015-2020, she worked at LUMC (Klynische Fysica) as a postdoc researcher in two projects: CLUES ( http://clues-iq.blogspot.com/p/main-page.html ) and a clinical ultra-low dose thorax CT project.

She is involved in several international working groups related to standardization of quality control in medical imaging, dose optimization and artificial intelligence implications. She actively participates as teacher in training courses, programs and curriculum development for medical physicists (EFOMP, ICRP).

Externe activiteiten

  • Associate Editor European Journal of Medical Physics (Physica Medica)
  • Reviewer for Physica Medica, Physics in Medicine and Biology, Journal of Medical Imaging, JOVE, Journal of Digital Imaging, Revista Sociedad Espanyola Física Médica (SEFM).
  • Member of the EFOMP working group on Cone-beam CT quality control standardization
  • Member of the ICRP 108 task group on “Optimisation of Radiological Protection in Digital Radiography, Fluoroscopy, and CT in Medical Imaging
  • Observer of the EFOMP working group on Artificial Intelligence
  • Teacher at the EFOMP summer school for Computed Tomography


Subjects open for accepting trainees and internships

If you are interested, either as a student or as a supervisor in a university program, please contact by email:

  •  Development of phantoms for image quality assessment. Anthropomorphic structures modelling
  • 3D printing materials X-ray characterization
  • Objective image quality assessment in CT: model observers
  • Artificial intelligence technologies validation
  • Human observer studies
  • Computed tomography: advanced systems validation and performance testing

Researcher profiles

For a more complete publication list, please see the following linkedin website and Google scholar profile

Key publications

  • Development of a 3D printed anthropomorphic lung phantom for image quality assessment in CT. Hernandez-Giron I, den Harder JM, Streekstra GJ, Geleijns J, Veldkamp WJH. Physica Medica (2019);57:47-57. Galileo Galilei Award as best scientific paper of Physica Medica in 2019
  • Added value of ultra-low-dose Computed Tomography, dose equivalent to chest X-ray radiography, for diagnosis chest pathology. Kroft LJM, van der Velden L, Hernandez-Giron I, Roelofs J, de Roos A, Geleijns J. Journal of Thoracic imaging (2019);34(3):179-186
  • Automated assessment of low contrast sensitivity for CT systems using a model observer. Hernandez-Giron I, Geleijns J, Calzado A, Veldkamp WJH. Medical Physics (2011);38(S1):S25-S35.
  • Dosimetry of a cone beam CT device for oral and maxillofacial radiology using Monte Carlo techniques and ICRP adult reference computational phantoms. Morant JJ, Salvado M, Hernandez-Giron I, Casanovas R, Ortega R, Calzado A. Dentomaxillofacial Radiology (2013);42(3):92555893
  • Quality control in cone/beam computed tomography (CBCT) EFOMP-ESTRO-IAEA protocol (2017)http://dx.medra.org/10.19285/CBCTEFOMP.V1.0.2017.06
  • Image quality in CT: From physical measurements to model observers (Review paper). Verdun FR, Racine D, Ott JG, Tapiovaara MJ, Toroi P, Bochud FO, Veldkamp WJH, Schegerer A, Bouwman RW, Hernandez-Giron I, Marshall NW, Edyvean S. Physica Medica (2015);31(8):823-843.
  • PhD thesis: Model observers applied to low contrast detectability in Computed Tomography. Hernandez-Giron I (2016), supervisors: Dr. Calzado, Dr. Veldkamp (http://eprints.ucm.es/41583/1/T38519.pdf).


Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden

Postzone C2-S
Postbus 9600
2300 RC Leiden

E-mail: I.Hernandez_Giron@lumc.nl