Osteoarthritis

Prof. Dr. J.L. Bloem, Dr. H.M.Kroon

Focus

The development of degeneration of joints, osteoarthritis, is based on multiple factors. Among these are primary causes as age, obesity and genetics. Osteoarthritis can develop secondary to trauma, infection or systemic diseases such as rheumatoid arthritis or acromegaly. Degeneration of joints has a major, increasing impact on health costs. Imaging aims at identify parameters predicting development and course of osteoarthritis, as well as monitoring and predicting response to treatment. Conventional radiographs, including automated image analysis, and MR of cartilage and subchondral bone including its perfusion are main methods used in various studies.

Study populations

Dutch obesity study (NEO study), acromegaly population, CHECK, GEMSTONE

Collaborative networks

  • Department of Rheumatology (Prof. dr. T.W.J. Huizinga andDr. G. Kloppenburg), Pathology (Prof.dr. P.C.W. Hoogendoorn,), Endocrinology (Prof.dr, J.W.A. Smit), Molecular Epidemiology (Dr P.E. Slagboom), and Orthopedics (Prof.dr. R.G.H.H. Nelissen).