Deep Brain Stimulation

Optimizing patient selection for deep brain stimulation       

The OPTIMIST study (OPTIMIzing patient selection for deep brain STimulation of the subthalamic nucleus in Parkinson's disease) aims to investigate a multidimensial screening battery to improve the selection process for deep brain stimulation (DBS). Preoperative evaluation tools will be used to build a statistical model that aims to predict the succes of DBS. With this model, we aim at better identifying those patients who will likely benefit most from DBS and which patients are less suitable candidates for surgery.

For example, it is known that some symptoms, such as 'freezing' during walking or cognitive complaints, do not improve after surgery. The screening tests therefore encompass a combination of both motor- and non-motor symptoms. Enhancing our current knowledge of the predictive role of disease features allows us to better weigh the individual risk-benefit for patients and improve patient care.                                                                                                                                                                                                

The OPTIMIST study is a joint project in which we collaborate with the 'HagaZiekenhuis' in The Hague and the 'Medisch Spectrum Twente' in Enschede.