Paroxysmal Cerebral Disorders (PaCD)
The LUMC Paroxysmal Cerebral Disorders research group is focused at important and prevalent paroxysmal cerebral disorders, foremost migraine, cluster headache, narcolepsy, syncope and epilepsy, to unravel the spectrum of neurobiological causes and consequences of these brain disorders. The aim is to understand disease mechanisms, to predict and prevent attacks, to identify targets for drug treatment, to develop tailored (including sex-specific) treatments, and to test novel treatment modalities.
Headache
The headache research group focuses on neurobiological and molecular triggering mechanisms that lead up to migraine and cluster headache attacks to identify treatment targets for prediction and prevention of attacks and disease progression. The Leiden Headache group is also studying pathogenesis of monogenic disorders such as Hemiplegic Migraine and Cerebral Hereditary Angiopathies, which serve as models for migraine pathogenesis and help improve insight into the pathophysiology of common neurovascular disorders, including stroke and vascular dementia. The group is also involved in exploring the migraine–stroke relationship, with a special focus on female-specific triggers for migraine and stroke.