Parkinson's Disease

Parkinson's disease is a progressive neurodegenerative disease affecting almost 2% of the population over 65. The disease is characterized by motor symptoms such as bradykinesia, rigidity, resting tremor, postural instability and non-motor symptoms such as cognitive dysfunction, depressed mood, nocturnal sleep problems, daytime somnolence and autonomic disturbances. Parkinson's disease is not a single disease; epidemiological, genetic and experimental studies suggest that environmental and genetic factors that compromise processes fundamental to neuronal vitality may contribute to the pathobiology of this disorder. Patients with Parkinson's disease do not follow a uniform disease course, but exhibit conspicuous differences in the profile of primary disease-related and medication-induced complications as well as in the rate of progression of the disease, reflecting the existence of subtypes.