Frank R. de Gruijl (1954) studied Physics (M.Sc., 1977) and did his Ph.D. (1982, ‘summa cum laude’) at the Utrecht University on experimental UV carcinogenesis and mathematical modeling of increases in skin cancer due to a depletion of stratospheric ozone. After an intermezzo of 5 years in industry (as a seismic exploration geophysicist with Shell Research in the Netherlands, and EXPRO in London, UK) he was awarded a Beijaardt fellowship by the Royal Dutch Academy of Sciences in 1987, and returned to skin cancer research at the department of Dermatology of the Academic Hospital in Utrecht. In 1993 he succeeded his mentor prof. Jan van der Leun as leader of the photo-dermatologic research group.
In 2001 his group moved to the department of Dermatology of the Leiden University Medical Center, where he continued his collaborative basic research with dr. Leon Mullenders of the department of Toxico-Genetics (then “Radiation Genetics”) on the impact of DNA repair defects on UV carcinogenesis. In collaboration with Dr. Jan Nico Bouwes Bavinck the research shifted toward the skin cancer risk in renal transplant patients, and in parallel, the photo-dermatological research focused on “sun allergy” (i.e. polymorphic light eruption) in collaboration with Dr. Stan Pavel. More recently, de Gruijl’s research interests also include UV-induced vitamin D3 and its impact on (internal) malignancies.
As an expert on UV-related health issues he participates or participated in various national and international committees: e.g., the International Commission on Non-Ionizing Radiation Protection, ICNIRP (1997-2008), ozone layer science panel for UNEP, Dutch Health Council, SCENIHR working groups of the EU, and chairing a task group of the Dutch Cancer Society on “UV, vitamin D and cancer” (2007-2010).
Leids Universitair Medisch Centrum
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