Inflammatory Bowel Disease

Inflammatory Bowel Diseases

The four members of the scientific staff that perform basic, translational and clinical research in the field of Inflammatory Bowel Diseases (IBD) are Dr. Andrea van der Meulen, Dr. Jeroen Maljaars, Prof. dr. Hein Verspaget and Prof. Daan Hommes. Our research is focused on several aspects of IBD, with special attention for extra intestinal manifestations of both Crohn’s disease and Ulcerative colitis, E-health and value-based medicine. 

Our current projects:

Stem cell therapy for IBD

PhD student: drs. Marieke Barnhoorn, MD

PI: prof dr. ir. H. Verspaget and dr. AE van der Meulen – de Jong


• Fecal Microbiota Transplantation. A randomised controlled trial comparing FECal Microbiota Transplantation after BUDesonide or  placebo induction in patients with ulcerative colitis: the FECBUD trial

PhD student: drs. Emilie van Lingen, MD

PI: dr. Josbert keller (gastroenterologist MCH, the Hague), prof. dr E. Kuijper, microbiologist, dr. AE van der Meulen – de Jong

                        

IBD in the elderly

PhD student: drs. Vera Ascher, MD 

PI: dr. PWJ Maljaars


IBD and nutrition

Post DOC: dr. Ilse Molendijk

PI: dr. PWJ Maljaars


• Implementation of quality improvements within the IBD care  

PhD student: drs. Niene Peek, gastroenterologist

PI:     dr. A.E. van der Meulen-de Jong and dr. L. Van Bodegom-Vos


• High-Dimensional Single-Cell Analysis By Mass Cytometry (CyTOF) Of The Mucosal    Intestinal Immune System In Health And Disease

Goal: To unravel the role of immune subsets in intestinal

pathology using a system-wide analysis approach by combining mass cytometry with computational tools

Collaboration with the department of Immunohematology and Bloodtransfusion

PhD student: Vincent van Unen

PI: Prof dr Frits Koning

Sub-investigator: dr AE van der Meulen – de Jong

Member of the TIMID consortium


eHEALTH

Goal: Development and validation of a telemedicine tool to enable continuous monitoring of PROMs and PREMs of all inflammatory bowel disease patients.

Collaboration with Maastricht University Medical Center, and member of Stichting MijnIBDcoach

PI LUMC: dr AE van der Meulen - de Jong

Project goal

Development and validation of a telemedicine tool to enable continuous monitoring of PROMs and PREMs of all inflammatory bowel disease patients.

Background and motivation

Our pragmatic, randomised trial (n=909) compared the telemedicine tool myIBDcoach with standard outpatient care for patients with inflammatory bowel disease, regardless of disease course or treatment. We found that use of myIBDcoach resulted in a reduction in outpatient visits, telephone consultations, and hospitalisations, and increased adherence to medication. In addition, it was safe and patient-reported quality of healthcare remained consistently high. Link


Collaboration projects

As active member of the ICC (Initiative Crohn and Colitis) we perform many multicenter studies. Link


Clinical research into new therapies

On the one hand, we conduct our own research into new treatment methods, and on the other we take part in so-called 'clinical trials' (medicine research). In this way we want to operate at the forefront of the development and application of new treatments. In this way, we can also offer patients therapies that are not yet covered by regular care. These studies are organized by the Trial Office of our department, under direct supervision of dr AE van der Meulen – de Jong and dr. PWJ Maljaars.