- Diagnostics and treatment of van viral infections
- Infections in immunocompromised patients
- Human herpesviruses
- Parvovirus B19
Department of Medical Microbiology
Professor of Clinical Virology, MD
Head of the Department
The study of viral infections is in a flourishing period, not only because of the increasing frequency of viral plagues affecting man and animals, but also because of the availability of new and powerful tools to study viruses. Viral infections used to be a difficult object for study, now molecular analysis in many ways has radically changed this field. Application of new insights in clinical practice is a real challenge, serving as an intermediary between fundamental developments and the patient. It is important to propagate new possibilities but also to suppress unjustified expectations; as currently we are far from controlling all threats of viral infections.
A.C.M. (Louis) Kroes (1957), M.D., Ph.D., graduated in Medicine at the University of Amsterdam (1983), did a Ph.D. study at the Erasmus University Rotterdam in Biochemistry and Hematology ("The inactivation of cobalamin by nitrous oxide: applications in experimental chemotherapy of leukemia", 1987), trained in Internal Medicine (1986-1988) and specialized in Medical Microbiology (1992), also in Rotterdam.
At Leiden University Medical Center (LUMC), he was appointed Head of the Clinical Virology Laboratory (1993) and subsequently became Head of the Clinical Microbiology Laboratory (1999), Professor of Clinical Virology (2003) and Head of the Department of Medical Microbiology (2007) at this university hospital. He is supervisor of the medical specialist training in Medical Microbiology at the LUMC.
He has served as the chairman of the Dutch Clinical Virology Working Group (1999-2008), as board member of the Dutch Society for Medical Microbiology (2007-2016) and council member of the European Society for Clinical Virology (2008-2016). Presently he is Chairman of the Dutch Council for Specialist training in Medical Microbiology (the Concilium).
His scientific interest is devoted to a number of different areas within the field of clinical virology, notably:
- viral infections of the immunocompromised host (cytomegalovirus, Epstein-Barrvirus, adenovirus)
- influenza viruses
- parvovirus B19
- viral hepatitis B and C
- antiviral therapy
On these subjects he has authored around 160 peer reviewed publications (2017).
His inaugural lecture (in Dutch) on March 26, 2004 was entitled: Het virus: tussen leven en dood (The virus: between life and death).
Rhinovirus viremia in adult patients with high viral load in bronchoalveolar lavages. van Rijn AL, Claas EC, von dem Borne PA, Kroes ACM, de Vries JJC. J Clin Virol. 2017 Nov;96:105-109. doi: 10.1016/j.jcv.2017.10.007.
Detection of parvovirus B19 DNA in blood: Viruses or DNA remnants? Molenaar-de Backer MW, Russcher A, Kroes AC, Koppelman MH, Lanfermeijer M, Zaaijer HL. J Clin Virol. 2016 Nov;84:19-23. doi: 10.1016/j.jcv.2016.09.004.
Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology-oncology patients. Gooskens J, Marijt WA, van Essen EH, Rimmelzwaan GF, Kroes AC. Bone Marrow Transplant. 2016 Jan;51(1):138-41. doi: 10.1038/bmt.2015.214.
Clinical evaluation of viral acute respiratory tract infections in children presenting to the emergency department of a tertiary referral hospital in the Netherlands. Gooskens J, van der Ploeg V, Sukhai RN, Vossen AC, Claas EC, Kroes AC. BMC Pediatr. 2014 Dec 10;14:297. doi: 10.1186/s12887-014-0297-0.
The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. de Vries JJ, van Zwet EW, Dekker FW, Kroes AC, Verkerk PH, Vossen AC. Rev Med Virol. 2013; 23:241-9Failure of pre-emptive treatment of cytomegalovirus infections and antiviral resistance in stem cell transplant recipients. van der Beek MT, Marijt EW, Vossen AC, van der Blij-de Brouwer CS, Wolterbeek R, Halkes CJ, Claas EC, Kroes AC. Antivir Ther. 2012; 17:45-51.
Human parvovirus B19 genotype 3 associated with chronic anemia after stem cell transplantation, missed by routine PCR testing. Knoester M, von dem Borne PA, Vossen AC, Kroes AC, Claas EC. J Clin Virol. 2012; 54:368-70
Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus. Posthuma CC, van der Beek MT, van der Blij-de Brouwer CS, van der Heiden PL, Marijt EW, Spaan WJ, Claas EC, Nederstigt C, Vossen AC, Snijder EJ, Kroes AC. J Clin Virol. 2011; 51:25-30.
Morbidity and mortality associated with nosocomial transmission of oseltamivir-resistant influenza A(H1N1) virus. Gooskens J, Jonges M, Claas EC, Meijer A, van den Broek PJ, Kroes AC. JAMA. 2009; 301:1042-6.
Quantitative detection of herpes simplex virus DNA in the lower respiratory tract. Gooskens J, Templeton KE, Claas EC, van Bussel MJ, Smit VT, Kroes AC. J Med Virol. 2007; 79:597-604.
Sequential emergence of multiple adenovirus serotypes after pediatric stem cell transplantation. Kroes AC, de Klerk EP, Lankester AC, Malipaard C, de Brouwer CS, Claas EC, Jol-van der Zijde EC, van Tol MJ.. J Clin Virol. 2007; 38:341-7
Leids Universitair Medisch Centrum
2333 ZA Leiden
2300 RC Leiden