N.M.Appelman-Dijkstra MD, PhD

Director Center for Bone Quality

Area(s) of interest

  • Endocrinology
  • Internal Medicine


Natasha Appelman-Dijkstra (1980) is an internist-endocrinologist specialized in osteoporosis, metabolic bone diseases and calcium/phosphate disturbances. She received her MD in 2004 (Leiden University) and registered as an internist-endocrinologist in 2012 (Leiden University Medical Center). In 2015 she defended her thesis, titled "Longterm effects of cranial irradiation and growth hormone therapy" (Leiden University 2015). Since 2012 she works as a staff member at the Leiden University Medical Center (LUMC) where she developed the Coordinated Care Trajectory Osteoporosis which was rewarded a Gold medal from the International Osteoporosis Foundation for operational excellence and also was reponsible for several successful research projects

Clinical Care

Since 2016 she is the head of the Center for Bone Quality in Leiden and the co-founder and secretary of the “NVE-BoNe”, a national working group for calcium and bone disorders of the Dutch society for Endocrinology (NVE). Natasha is an active member of the Dutch Hyperparathyroid Study Group, a multidisciplinary alliance between several Academic and non-Academic hospitals to improve the care and research in parathyroid patients. In November 2017 she was elected president of the Dutch association for calcium and bone research (NVCB). Natasha is PI on several clinical initiated and industry sponsored studies in the field of impact micro indentation, rare bone diseases, osteoporosis and parathyroid-disorders. 

Since 2019 she is the director of the Academic Residency training program for Endocrinology of the LUMC.




In 2018 Natasha supervises the European Calcified Tissue Soctiety Translational Fellowship of Manuela Schobb, MD in Leiden on impact microindentation.

Current PhD students: Marlous Rotman: Fibrous Dysplasia.

Groupmembers: Liesbeth Winter, MD PhD, Nathalie Bravenboer PhD, Manuela Schobb MD.

Research Programme , Einthoven Laboratorium , Centrum van Botkwaliteit




Leiden University Medical Center
Building 1
Room C7-Q-48

Albinusdreef 2
2333 ZA Leiden
Tel: +31 (0)71 5263082 (secr.)

Postalzone C7-Q-48
P.O. Box 9600
2300 RC Leiden
The Netherlands

E-mail: bot@lumc.nl