Dr. J.J.C. (Jutte) de Vries

Assistant Professor, PI viral metagenomics


  • Clinical virology
  • Viral metagenomics
  • Viral respiratory infections
  • Viral meningitis/encephalitis
  • Viral infections in immunocompromised patients

Professional Biosketch

Dr. Jutte de Vries is a clinical virologist and assistant professor at the LUMC dept. of Medical Microbiology, the Netherlands.
She obtained several Masters degrees at the Leiden University: Biomedical Sciences (2000), Doctor of Medicine (2002), and Clinical Epidemiology B (2013). After her training as Medical Microbiologist at the University Medical Center in Groningen (2003-2008), she became a Fellow Clinical Virology at the Leiden University Medical Center (2008-2012) and wrote her thesis entitled: “Congenital cytomegalovirus infection: disease burden and screening tools -Towards newborn screening-“ (2012). After her PhD, she retained staff member clinical virology at the LUMC dept. of Medical Microbiology (to date), with several coordinating function including: head of the serology laboratory unit, staff member accreditation, and coordinator of the half minor Infections in Health and Disease.
Since 2016 she leads a group working on Viral Metagenomics, aiming at pathogen detection in clinical samples by both shotgun and targeted metagenomic next-generation sequencing. Other goals are to study the human virome in health and disease, viral resistance, typing, and virus discovery by metagenomic sequencing. The focus is on patients with encephalitis, viral respiratory infections, fever in travellers and immunocompromised (pediatric and adult) patients. The ultimate goal of their work is to improve virus identification in undiagnosed patients suspected of an infectious disease.
Dr. de Vries is board member of the Dutch Working group Clinical Virology (NWKV), and co-initiator and coordinator of the European Society of Clinical Virology (ESCV)-network on NGS (ENNGS), aiming at implementation of NGS in the clinical diagnostic laboratory, for pathogen detection and typing.
Her research is/was supported by local, regional, and national funders including Generade and the Leiden University Fund (LUF) Nypels-van der Zee (https://www.luf.nl/nieuws/2019/onderzoek-naar-een-betere-behandeling-van-hersenontsteking).

Key publications

Retrospective validation of a metagenomic Sequencing protocol for combined detection of RNA and DNA viruses using respiratory samples from paediatric patients. Sander van Boheemena, Anneloes L. van Rijn, Nikos Pappas, Ellen C. Carbo, Ruben H.P. Vorderman, Igor Sidorov, Peter J. van `t Hof, Hailiang Mei, Eric C.J. Claas, Aloys C.M. Kroes, Jutte J.C. de Vries. J Molecular Diagnostics: Accepted (2019) for publication

The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease. van Rijn AL, van Boheemen S, Sidorov I, Carbo EC, Pappas N, Mei H, Feltkamp M, Aanerud M, Bakke P, Claas ECJ, Eagan TM, Hiemstra PS, Kroes ACM, de Vries JJC. PLoS One. 2019 Oct 24;14(10):e0223952. doi: 10.1371/journal.pone.0223952. 

The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease. Van Rijn AL, Van Boheemen, S, Carbo EC, Pappas N, Sidorov I, Mei H, Aanerud M, Bakke P, Claas ECJ, Eagan TM, Hiemstra PS, Kroes ACM, De Vries JJC. bioRxiv 2019 doi: https://doi.org/10.1101/509919

Metagenomic sequencing for combined detection of RNA and DNA viruses in respiratory samples from paediatric patients. Van Boheemen S, Van Rijn-Klink AL, Pappas N, Carbo EC, Vorderman RHP, Van ’t Hof PJ, Mei H, Claas ECJ, Kroes ACM, De Vries JJC. bioRxiv 2018 doi: https://doi.org/10.1101/492835

Next-generation sequencing in clinical virology. Van Rijn-Klink AL, De Vries JJC, Claas ECJ Book chapter in Novel diagnostics for the clinical microbiological laboratory, in press

Rhinovirus viremia in adult patients with high viral load in bronchoalveolar lavages. Van Rijn AL, Claas EC, Von Dem Borne PA, Kroes ACM, De Vries JJC. J Clin Virol 2017 96:105-109 

Valganciclovir for Congenital Cytomegalovirus. Korndewal MJ, De Vries JJC, De Melker HE. N Engl J Med 2015;18:372:2462-3

Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness. Zlateva KT, De Vries JJC, Coenjaerts FE, Van Loon AM, Verheij T, Little P, Butler CC, Goossens H, Ieven M, Claas EC; GRACE Study Group Euro Respir J 2014;44:169-77

The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. De Vries JJC, Van Zwet, Dekker FW, Kroes AC, Verkerk PH, Vossen AC. Rev Med Virol 2013;23(4):241-9

Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness. De Vries JJC, Vesseur A, Rotteveel LJ, Korver AM, Rusman LG, Wessels E, Kroes AC, Mylanus EA, Oudesluys-Murphy AM, Frijns JH, Vossen AC. J Clin Virol 2013;56:113-7

Rapid genotyping of CMV in dried blood spots by multiplex real-time PCR assays targeting the envelope glycoprotein gB and gH genes. De Vries JJC, Wessels E, Korver AMH, van der Eijk AA, Rusman LG, Kroes ACM, Vossen ACTM. J Clin Microbiol 2012;50(2):232-7

Congenital CMV infection: prevention is better than treatment. Korver AMH, De Vries JJC, Oudesluys-Murphy AM. J Pediatr 2011;159:877

Implementing neonatal screening for congenital cytomegalovirus: addressing the deafness of policy makers - Review. De Vries JJC, Vossen ACTM, Kroes ACM, Van der Zeijst BAM. Rev Med Virol 2011;21(1):54-61

Screening newborns for congenital cytomegalovirus infection. De Vries JJC, Vossen ACTM, Kroes ACM. JAMA 2010 Jul 28;304(4):407

All publications by Jutte de Vries.


Leids Universitair Medisch Centrum
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