Dr. M.C.W. (Mariet) Feltkamp

Assoc Professor of Medical Virology; papillomavirus and polyomavirus expert

Vakgebied(en)

  • Medische Virologie
  • Humaan polyomavirus (HPyV), infectie, epidemiologie and pathogeniteit
  • Humaan papillomavirus (HPV) en huidkanker
  • HPV vaccinatie en baarmoederhalskanker screening

Introductie

Mariet Feltkamp is als medisch viroloog en associate professor verbonden aan de afdeling Medische Microbiologie van het LUMC. Zij is een RGS/BIG-geregistreerd medisch specialist (arts microbioloog).

Als prinipal investigator doet Feltkamp onderzoek naar humane polyomavirus (HPyV) en papillomavirus (HPV) infecties. In het verleden heeft zij gedurende 4 jaar een prestigieuze ZonMW-Klinische Fellowship ontvangen. Recent heeft zij Novartis 2018 Transplantation award gewonnen voor haar werk aan BK-polyomavirus infectie in niertransplantatie-patienten.

Naast zorg en onderzoek is Feltkamp president van de European Society for Clinical Virology (ESCV), en o.a. lid van de Commissie Genetische Modificatie (GOGEM) en de Programmacommissie Bevolkingsonderzoek Baarmoederhalskanker (Progcie BVO BMHK). Je kan haar volgen op Twitter @MarietFeltkamp 

 


Research interests

Human papillomavirus (HPV) and polyomavirus (HPyV) infections pose a number of serious medical problems, especially in immunocompromized hosts. These include cervical cancer, nonmelanoma and Merkel-cell skin cancer, as well as nephropathy in renal transplant patients and progressive multifocal encephalopathy (PML).

Cutaneous HPVs and especially HPyVs cause persistent, lifelong infection which generally go unnoticed (latent) in healthy individuals. In case of reduced immunity, acquired or intentionally after immunosuppressive drug use, these latent infections are no longer controlled and reactivate. In some cases, fulminant reactivations can cause organ failure and death. My research is aimed at identifying host and virus factors that determine vulnerability to these (reactivating) infections. In order to do so, we study the epidemiology and evolution of these viruses, as well as pathogenic properties involved in disease development and disruption of intracellular (molecular) pathways. This knowledge should aid to decrease the risk of HPV and HPyV infections in immunocompromised individuals, and increase the succes of solid organ transplnatation. 


Professional biosketch

Mariet Feltkamp is a medical virologist and associate professor at the LUMC Dept of Medical Microbiology. She is a Dutch certified medical microbiologist working in clinical virology and research.         

After obtaining her medical degree at the University of Amsterdam in 1990, four years of basic research of papillomavirus immunology were spend in the labs of Jan ter Schegget, Martin Kast and Kees Melief at the Amsterdam Academic Medical Center, the Netherlands Cancer Institute and the Leiden University Medical Center (LUMC), respectively. With a PhD and a steady basis in fundamental research she returned to medicine in 1995. After training as a medical microbiologist in 1998, she fulfilled her ambition to combine clinical virology with research into viral oncogenesis. In the LUMC she started a successful research line investigating the involvement of HPV in the development of cutaneous squamous-cell carcinoma. With the help of a 4-year Clinical Fellowship (ZonMW), a substantial part of her appointment could be allocated from patient care to virus research. Apart from ZonMW, she obtained grants also from the European Union (EU), the Dutch Cancer Society (KWF), and the Dutch Research Council (NWO).        

In 2010 she discovered a new human polyomavirus in the skin lesions of a trichodysplasia spinulosa patient (van der Meijden et al). The virus was called the trichodysplasia spinulosa-associated polyomavirus (TSV of TSPyV) and is recognized a separate polyomavirus species (TSPyV patent). Currently Feltkamp is zooming in on the epidemiology and pathogenesis of clinically relevant polyomavirus infections, including TSPyV and BKPyV. For the latter she received the Novartis Transplantation Award 2018 for showing that BKPyV antibody titers of kidney transplant donors predict BKPyV viremia and nephropaty in recipients after transplantation.        

A summarized CV of Mariet Feltkamp can be found on LinkedIn. You can follow Mariet Feltkamp on Twitter.

 


Scientific publications

Feltkamp published >100 articles in scientific journals, including Nature and NEJM. A comprehensive and up-to-date publication list can be found on PubMed.


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1
Kamer E4-57

Albinusdreef 2
2333 ZA Leiden
Tel: +31(0)715264832

Postzone E4-P
Postbus 9600
2300 RC Leiden

E-mail: m.c.w.feltkamp@lumc.nl