Dr. M.C.W. (Mariet) Feltkamp

Associate Professor of Medical Virology; HPV and polyomavirus expert

Vakgebied(en)

  • Medical Virology
  • Human polyomavirus (HPyV) infection, epidemiology and pathogenicity
  • Human papillomavirus (HPV) and cervical cancer screening and vaccination
  • Social media, twitter handle @MarietFeltkamp

Introductie

Mariet Feltkamp is als medisch viroloog en associate professor werkzaam op de afdeling Medische Microbiologie van het LUMC. Zij is een RGS/BIG-geregistreerd arts-microbioloog opgeleid in de medische microbiologie (medisch specialisme). Naast haar klinisch diagnostische taken doet zij als prinipal investigator onderzoek naar humane polyomavirus (HPyV) en Papillomavirus (HPV) infecties. In het verleden heeft zij gedurende 4 jaar een prestigieuze ZonMW-Klinische Fellowship ontvangen. Recent heeft zij Novartis 2018 Transplantation award gewonnen voor haar werk aan BK-polyomavirus infectie in niertransplantatie-patienten.

 


Research interests

Human papillomavirus (HPV) and polyomavirus (HPyV) infections pose a number of serious medical problems, especially in immunocompromized hosts. These include cervical cancer, nonmelanoma and Merkel-cell skin cancer, as well as nephropathy in renal transplant patients and progressive multifocal encephalopathy (PML).

Cutaneous HPVs and especially HPyVs cause persistent, lifelong infection which generally go unnoticed (latent) in healthy individuals. In case of reduced immunity, acquired or intentionally by immunosuppressive drug use, these latent infections are no longer controlled and reactivate. In some cases, fulminant reactivations can cause organ failure and death. My research is aimed at identifying host and virus factors that determine vulnerability to these (reactivating) infections. In order to do so, we study the epidemiology and evolution of these viruses, as well as pathogenic properties involved in disease development and disruption of intracellular (molecular) pathways.


Professional biosketch

Mariet Feltkamp is a medical virologist and associate professor at the LUMC Dept of Medical Microbiology. She is a Dutch certified medical microbiologist working in clinical virology and research.

After obtaining her medical degree at the University of Amsterdam in 1990, four years of basic research of papillomavirus immunology were spend in the labs of Jan ter Schegget, Martin Kast and Kees Melief at the Amsterdam Academic Medical Center, the Netherlands Cancer Institute and the Leiden University Medical Center (LUMC), respectively. With a PhD and a steady basis in fundamental research she returned to medicine in 1995. After training as a medical microbiologist in 1998, she fulfilled her ambition to combine clinical virology with research into viral oncogenesis. In the LUMC she started a successful research line investigating the involvement of HPV in the development of cutaneous squamous-cell carcinoma. With the help of a ZonMW Clinical Fellowship, a substantial part of her appointment could be allocated from patient care to virus research. Apart from ZonMW, also grants from the European Union (EU) and the Dutch Cancer Society (KWF) were obtained.

In 2010 she discovered a new human polyomavirus in the skin lesions of a trichodysplasia spinulosa patient (van der Meijden et al). The virus was called the trichodysplasia spinulosa-associated polyomavirus (TSV of TSPyV) and is recognized a separate polyomavirus species (TSPyV patent). Currently Feltkamp is zooming in on the epidemiology and pathogenesis of clinically relevant polyomavirus infections, including TSPyV and BKPyV.

A summarized CV of Mariet Feltkamp can be found on LinkedIn.  

You can follow Mariet Feltkamp on Twitter


Scientific publications

Mariet has published approx. 100 atricles in various scientific journals, including Nature and New Engl J Medicine. A recent selection is shown below         

Primary polyomavirus infection, not reactivation, as the cause of trichodysplasia spinulosa in immunocompromised patients. van der Meijden E, Horváth B, Nijland M, de Vries K, Rácz E, Diercks GF, de Weerd AE, Clahsen-van Groningen MC, van der Blij-Brouwer CS, van der Zon AJ, Kroes AC, Hedman K, van Kampen JJ, Riezebos-Brilman A, Feltkamp MCJ Infect Dis. 2016 Aug 30 [Epub ahead of print]

Pretransplantation Donor-Recipient Pair Seroreactivity Against BK Polyomavirus Predicts Viremia and Nephropathy After Kidney Transplantation. Wunderink HF, van der Meijden E, van der Blij-de Brouwer CS, Mallat MJ, Haasnoot GW, van Zwet EW, Claas EC, de Fijter JW, Kroes AC, Arnold F, Touzé A, Claas FH, Rotmans JI, Feltkamp MCAm J Transplant. 2016 Jun 2 [Epub ahead of print]

Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa. van der Meijden E, Kazem S, Dargel CA, van Vuren N, Hensbergen PJ, Feltkamp MC.  J Virol. 2015 Sep 15;89(18):9427-39.

Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region. Lauber C, Kazem S, Kravchenko AA, Feltkamp MC, Gorbalenya AE.  Nucleic Acids Res. 2015 May 26;43(10):4800-13.

Human Beta-papillomavirus infection and keratinocyte carcinomas. Quint KD, Genders RE, de Koning MN, Borgogna C, Gariglio M, Bouwes Bavinck JN, Doorbar J, Feltkamp MC.  J Pathol. 2015 Jan;235(2):342-54.

Polyomavirus-associated Trichodysplasia spinulosa involves hyperproliferation, pRB phosphorylation and upregulation of p16 and p21. Kazem S, van der Meijden E, Wang RC, Rosenberg AS, Pope E, Benoit T, Fleckman P, Feltkamp MC.  PLoS One. 2014 Oct 7;9(10):e108947.

Different serologic behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 polyomaviruses found on the skin. van der Meijden E, Bialasiewicz S, Rockett RJ, Tozer SJ, Sloots TP, Feltkamp MC.  PLoS One. 2013; 8:e81078.

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M. Nature. 2012 Jul 26;487(7408):491-5

Trichodysplasia spinulosa is characterized by active polyomavirus infection.Kazem S, van der Meijden E, Kooijman S, Rosenberg AS, Hughey LC, Browning JC, Sadler G, Busam K, Pope E, Benoit T, Fleckman P, de Vries E, Eekhof JA, Feltkamp MC.  J Clin Virol. 2012; 53:225-30.

Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. van der Meijden E, Janssens RW, Lauber C, Bouwes Bavinck JN, Gorbalenya AE, Feltkamp MC.  PLoS Pathog. 2010; 6:e1001024.

All publications by Mariet Feltkamp listed in PubMed   

 


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1
Kamer E4-57

Albinusdreef 2
2333 ZA Leiden
Tel: +31(0)715264832

Postzone E4-P
Postbus 9600
2300 RC Leiden

E-mail: m.c.w.feltkamp@lumc.nl