Dr. A.C.T.M. (Ann) Vossen

Associate Professor, PI Congenital cytomegalovirus infection


  • Clinical Virology
  • Cytomegalovirus and Herpes simplex virus
  • Antiviral resistance
  • Congenital Cytomegalovirus infections


Department of Medical Microbiology
Associate Professor, MD
PI Congenital cytomegalovirus infection: disease burden and vaccines

Research interests

  • Clinical Virology
  • Diagnostics
  • Viral infections in the immunecompromised host
  • Congenital and neonatal viral infections

Professional biosketch

After writing her thesis on “Cytokines and T lymphocytes in transplantation” at the department of Immunology at the Erasmus University in Rotterdam, Dr. A.C.T.M. Vossen was trained to become medical microbiologist at the same university. She worked as a clinical virologist at the department of Virology of the Erasmus Medical Center for seven years. In 2006 she became staff-member of the department of Medical Microbiology of the LUMC. Her clinical work covers the clinical virology. She is involved in research concerning herpesvirus infections in the immunecompromised host and congenital CMV infection.

Dr. Vossen is a member of the board of the Dutch Society of Medical Microbiology (NVMM) of the Dutch Foundation for Quality Assessment in Clinical Laboratories (SKML).

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Selected publications

Korndewal MJ, Vossen AC, Cremer J, van Binnendijk RS, Kroes AC, van der Sande MA, Oudesluys-Murphy AM, DE Melker HE. Disease burden of congenital cytomegalovirus infection at school entry age: study design, participation rate and birth prevalence. Epidemiol Infect. 2016 May; 144 (7): 1520-7.

Korndewal MJ, Mollema L, Tcherniaeva I, van der Klis F, Kroes AC, Oudesluys-Murphy AM, Vossen AC, de Melker HE. Cytomegalovirus infection in the Netherlands: seroprevalence, risk factors, and implications. J Clin Virol. 2015 Feb;63:53-8

Vermont CL, Jol-van der Zijde EC, Hissink Muller P, Ball LM, Bredius RG, Vossen AC, Lankester AC. Varicella zoster reactivation after hematopoietic stem cell transplant in children is strongly correlated with leukemia treatment and suppression of host T-lymphocyte immunity. Transpl Infect Dis. 2014 Apr;16(2):188-94

de Vries JJ, van Zwet EW, Dekker FW, Kroes AC, Verkerk PH, Vossen AC. The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. Rev Med Virol. 2013 Jul;23(4):241-9.

de Jong EP, Vossen AC, Walther FJ, Lopriore E. How to use... neonatal TORCH testing. Arch Dis Child Educ Pract Ed. 2013; 98:93-8.

van der Beek MT, Vermont CL, Bredius RG, Marijt EW, van der Blij-de Brouwer CS, Kroes AC, Claas EC, Vossen AC. Persistence and antiviral resistance of varicella zoster virus in hematological patients. Clin Infect Dis. 2013; 56:335-43.

van der Beek MT, Claas EC, van der Blij-de Brouwer CS, Morfin F, Rusman LG, Kroes AC, Vossen AC. Rapid susceptibility testing for herpes simplex virus type 1 using real-time PCR. J Clin Virol. 2013; 56:19-24.

van der Beek MT, Marijt EW, Vossen AC, van der Blij-de Brouwer CS, Wolterbeek R, Halkes CJ, Claas EC, Kroes AC. Failure of pre-emptive treatment of cytomegalovirus infections and antiviral resistance in stem cell transplant recipients. Antivir Ther. 2012; 17:45-51.

de Vries JJ, Korver AM, Verkerk PH, Rusman L, Claas EC, Loeber JG, Kroes AC, Vossen AC. Congenital cytomegalovirus infection in the Netherlands: birth prevalence and risk factors. J Med Virol. 2011; 83:1777-82.

Wolfert SI, de Jong EP, Vossen AC, Zwaveling J, Te Pas AB, Walther FJ, Lopriore E. Diagnostic and therapeutic management for suspected neonatal herpes simplex virus infection. J Clin Virol. 2011; 51:8-11.

de Vries JJ, Vossen AC, Kroes AC, van der Zeijst BA. Implementing neonatal screening for congenital cytomegalovirus: addressing the deafness of policy makers. Rev Med Virol. 2011; 21:54-6.

All publications by Ann C.T.M. Vossen in PubMed

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Leids Universitair Medisch Centrum
Gebouw 1
Kamer E4-57

Albinusdreef 2
2333 ZA Leiden
Tel: +31(0)715263646

Postzone E4-P
Postbus 9600
2300 RC Leiden

E-mail: a.c.t.m.vossen@lumc.nl