Dr Francoise Carlotti

Associate Professor



Françoise Carlotti, PhD is an Associate Professor in the Department of Internal Medicine, and is Head of the Islet Research lab.




We do fundamental and pre-clinical research on Type 1 and Type 2 Diabetes with a focus on primary human pancreatic cells and beta-cell replacement therapy building on an active clinical islet transplantation program.


Our two main research topics are:


    i)      Investigating mechanisms underlying beta-cell adaptation to (patho)physiological conditions,  islet cell plasticity and alterations in beta-cell identity associated with a loss of function.


     ii)      Regenerative medicine for diabetes: Making new insulin-producing cells from human pluripotent stem cells using GMP-compliant processes for translation to the clinic.




As PI, I obtained research funding from JDRF (2014 and 2017), the Dutch Diabetes Research Foundation (2015, 2019), the Dutch Kidney Foundation (2016), the DON foundation (2017, 2019), the European Foundation for the Study of Diabetes (2018), and TKI/Health Holland (2019).


I’m also a PI in Dutch consortium for regenerative medicine RegMedXB https://regmedxb.com/  and in the H2020 European consortia ISLET https://isletproject.eu/   and ESPACE https://www.espace-h2020.eu/






Leids Universitair Medisch Centrum
Gebouw 1
Kamer D3-39

Albinusdreef 2
2333 ZA Leiden
Tel: 071 526 2011

Postzone D3-P
Postbus 9600
2300 RC Leiden

E-mail: f.carlotti@lumc.nl