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Funding is essential to allow continuation of our research in the field of image guided surgery. Our donors and grant giving institutions underwrite the importance of our research and we are thankful for their long lasting and significant support.

The total value of funding awarded to the Image-Guided Surgery Research Group exceeds € 9 million.

SponsorTitle/TopicProject dateRole
Ongoing Research
National Institute of Health (NIH)Mediastinal lymph node identification in lung cancer using NIR fluorescent VATS2016 - 2021Subcontract Principal Investigator
NIHZW800-1: the first zwitterionic NIR fluorophore for cancer imaging and ureter mapping2016 - 2018Subcontract Principal Investigator
Stanford UniversityThe aim of this project is to determine the safety and efficacy of using cetuximab-IRDy800 for intraoperative pancreatic cancer detection using multimodality molecular imaging2016 - 2017Subcontract Investigator
Dutch Cancer Society (KWF)The overall aim of this project is to produce a novel fluorescent GMP-grade, tumor-specific EpCAM-targeted imaging agent that will aid surgical procedures, assist clinical decision making and improve treatment strategies for patients with rectal cancer UL2015-8089 2016 - 2019Prinicpal investigator
Dutch Cancer Society (KWF)Tumour-specific near-infrared fluorescence imaging in locally advanced and recurrent rectal cancer UL2018-113632018 - 2022Project Leader
European Research Council (ERC)The PRISAR project aims to develop hybrid fluorescence-labelled intraoperative tumor-margin specific probes in combination with optoacoustic equipment and postoperative targeted radiotherapy. H2020-MSCA-RISE-2014-644373 2015 - 2020Project Leader
ERCThe ASTONISH project (PI Philips Research) will develop solutions for multiple healthcare applications using breakthrough core optical imaging technologies in the areas of NIRS, X-ray, PPG and multimodal data fusion. H2020-Astonish-6925470-22016 - 2019Project Leader
KWFThe aim of this project is to provide surgical oncologists with a real-time fluorescence-based imaging technique to identify sentinel lymph nodes and tumors in breast and colorectal cancer patients for the complete and safe resection of targeted tissue. UL2010-4732 2011 - 2017Principal Investigator
EU Horizon 2020The ISPIC project aims to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. H2020-MSCA-ITN-2015-6757432016 - 2020Project Leader
EU FP7The CAReIOCA project aims at providing pathologists and/or surgeons novel non-invasive optical imaging at the cellular scale for fast cancer assessment using Full-Field Optical Coherence Tomography (FFOCT). FP7-ICT CARelOCA2012 - 2016Principal Investigator
KWF Bas Mulder awardThe watch-and wait policy in rectal cancer patients: International, multicenter evaluation and improvement. The aim of this project is to improve oncological safety of watch and wait strategy by implementation of NIR fluorescence imaging in selection and follow-up of patients. 2016 - 2020Supervisor Bas Mulder Award
KWF Bas Mulder awardThis project aims to improve the quality of surgical selection and resection using novel intraoperative imaging techniques in patients with pancreatic cancer.2015 - 2019Supervisor Bas Mulder Award
Intuitive SurgicalThe aim of this project is to determine the safety and efficacy of using cetuximab-IRDye800 for intraoperative pancreatic cancer detection using multimodality molecular imaging integrated in the DaVinci Surgical System. 2015 - 2016Prinicpal Investigator
Completed Research (last 3 years)
Nuts OhraClinical Testing of Folate-Targeting Agents A single center, phase 1 study on the feasibility to detect primary lung cancer and ovarian metastases during minimally invasive surgery using near-infrared fluorescence imaging and the tumor-targeted agent EC17. Nuts Ohra Frost Study 2013 - 2015Principal Investigator
KWFThis grant was awarded to allow cGMP synthesis, toxicity studies and development of an assay for the plasma detection of cRGD-ZW800-1, a novel tumor-targeted fluorescent agent developed in collaboration with Prof. J.V. Frangioni. UL2012-55612012 - 2015Principal Investigator
Center for Translational Molecular Medicine (CTMM)The MUSIS project aimed to develop new technologies that enable rapid clinical implementation of intraoperative near-infrared fluorescence (NIRF) imaging of tumor tissue in surgical oncology, by developing tumor-targeted NIRF agents and sensitive intraoperative NIRF camera systems. CTMM MUSIS 03O-202 2009 - 2015Project Leader
CTMMDeCoDe aimed to develop and validate molecular medicine solutions (e.g. laboratory tests and molecular imaging applications) for pre-, primary and metastatic colorectal cancer, with an emphasis on early and accurate detection/population screening, individualized and optimized staging and therapy decision. CTMM DeCoDe 03O-1012008 - 2013Project Leader
Commercial Research Support Image-Guided Surgery Group (LUMC&CHDR) 
On Target Laboratories, West Lafayette, United StatesClinical translation of folate-receptor targeted fluorescent tracers
SurgiMab, Montpellier, FranceIntraoperative imaging of colorectal and pancreatic cancer using CEA-targeted fluorescent tracers
Delcath Systems Ltd., New York City, United StatesPercutaneous liver perfusion with chemotherapy
Edinburgh Molecular Imaging (pending), Edinburgh, United KingdomClinical translation of folate-receptor targeted fluorescent tracers


To further develop this smart technology and to make it available for the patients as soon as possible, we greatly appreciate any form of your support. For more information on donating, click here or visit the website of the Bontius Stichting.

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