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The Image-Guided Surgery group at Leiden University Medical Center (LUMC), headed by Dr. Vahrmeijer focuses on safe and efficient clinical translation of image guided surgery applications to improve personalized clinical practice and enhance patient outcome.

Multidisciplinary collaboration

The broad clinical expertise at the LUMC involves multiple surgical departments, we work closely with the departments of (Oncologic) Surgery, Gynaecology, Thoracic Surgery, Urology, Neurosurgery and Head- and Neck surgery and performed numerous studies together. Besides, our affiliation with the departments of Radiology, Endocrinology, Image Processing and our GMP facility has resulted in extensive knowledge in probe development and preclinical validation.

GMP-logoThe department of Clinical Pharmacy and Toxicology, has a GMP-licensed pharmacy which is responsible for all pharmacy related activities of the clinical trials at the hospital and the CHDR.

Outside the hospital, we intensely collaborate with the Center for Human Drug Research. Dr Koos Burggraaf, professor in Translational Drug Development at the Leiden Academic Center for Drug Research and Research Director CVS & Metabolism is closely involved in the development and conduct of healthy volunteer and clinical studies and the supervision of several PhD students in this field of research. Click on Clinical translation tab for more information.

Jaarverslag CHDR pagina over 'collaboration lead to revolutionary surgery'
The Image-Guided Surgery group also benefits from the collaboration with mathematicians from Leiden University on the development of PK/PD models for the novel fluorescent diagnostics.

6.Through modelling, it becomes clear which parameters of the substance are important to predict the behaviour of a fluorescent molecule in the body of the patient. With this background knowledge, clinical research becomes more focused, quicker and safer. The information from the mathematical model may even help to design better markers, 'tweaking' their biochemical properties to optimise their systemic and local pharmacokinetics.

Combining our longstanding expertise in (pre-) clinical development and an efficient infrastructure, we offer a one-stop-shop approach for fast clinical translation. We present a unique combination of expertise and research infrastructure to research groups and companies who are developing near fluorescent probes for targeting specific structures. At any point in the development trajectory we can offer our services for a fast, high quality translation from preclinical validation to human studies, ultimately improving surgical outcome and patient care. Dr Vahrmeijer aims at disseminating this technique to collaborating hospitals all over the world. The Image-Guided Surgery group facilitates, stimulates and supports knowledge transfer and education.

This project is the culmination of successful multidisciplinary collaborations which are the future of innovative research. It’s fascinating to be able to literally see what a compound does.

Prof Burggraaf

Other national collaborations

Other national centres such as the VU Medical Center, the Netherlands Cancer Institute (NKI) University Medical Center Groningen (UMCG),  Catharina Hospital, Erasmus Medical Center, Maastricht University Medical Center+,  and the Department of Intelligent Systems of the Delft University of Technology are closely involved in our studies.

Philips Healthcare and Quest Medical Imaging are partners in the development and clinical validation of a hyperspectral camera in the visualisation of critical structures such as nerves and the distinction between tumor and healthy tissue and tissue oxygenation (H2020 ECSEL grant 692470).

International collaborations

Together with the Multimodality Molecular Imaging Lab (MMIL) of the Stanford University and the Harvard University we co-develop novel tumor targeted probes or fluorescent markers.

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13. 12. 14.In Europe, we collaborate in the development of tumor targeted antibody and small molecule tracers and in the development of imaging systems with the Antibody Engineering Group of the University College Londen, the Max Planck Institute for Experimental Medicine in Göttingen and with the department of Photonics Instrumentation for Health of the University of Strasbourg.

Collaborations with commercial partners in the field of probe and camera development.

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