Biology of Ageing and Thrombosis Appraisal of Valve Thickness and function, an in vivo Assessment


Alev Karasu, MD, PhD student

Project manager

Dr A. van Hylckama Vlieg

The incidence of venous thrombosis is increased in the elderly. To be able to fully elucidate the strong age-gradient of venous thrombosis, we must examine thrombosis in the context of the process of ageing. Ageing may lead to damaged valves, i.e. thicker and less flexible valves. A decrease in valvular function leads to reflux resulting in VT formation. The BATAVIA case-control study was performed to assess the effect of ageing of the venous valves and hypercoagulability on the risk of venous thrombosis. Secondary aims were to determine the presence and severity of the post-thrombotic syndrome in the elderly and to determine whether the found changes are of local origin or they are part of a larger generalized process.

We included 70 cases aged 70 years or older with a first venous thrombosis and 96 control subjects. All participants underwent an ultrasound examination of the venous valves in the popliteal and jugular veins. Furthermore, the frequency and severity of the post-thrombotic syndrome in the elderly was determined.