Thrombophilia, Hypercoagulability, and Environment and the risk of Venous ThromboEmbolism-study

ResearcherDr Astrid van Hylckama Vlieg
Project managersProf. dr F.R. Rosendaal
Dr A. van Hylckama Vlieg
CooperationDepartment of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom

Venous thrombosis is a multicausal disease which means that more than one risk factor is often necessary to cause the disease. Numerous risk factors for a first deep venous thrombotic event have been described, both environmental as well as genetic. However, most currently known risk factors do not appear to play an important role in the risk of recurrent thrombosis.

The main aim of this study is to determine whether hypercoagulability as measured with newly developed global tests is associated with an increased risk of DVT. A case-control study is currently conducted to estimate the risk of a first thrombotic event in association with a global test of hypercoagulability. Subsequently, the cases will form a cohort for prospective follow-up to examine risk of recurrent DVT in relation to hypercoagulability.

Soon after the thrombotic event, patients and their partners will be invited to participate in the study. All participants will fill in a detailed questionnaire regarding life-style and possible risk factors for venous thrombosis. On completion of a standard duration of anticoagulant therapy patients and their partners will attend the anticoagulant clinic for a blood sample and an interview, two months after stopping treatment.

The results of this study will show whether global testing has clinical predictive value and in addition, if current thrombophilia testing can be rationalised with the possibility of using global testing as the first line investigation, with thrombophilia testing restricted to individuals from thrombosis-prone families with evidence of hypercoagulability.