NEtherlands COoperative Study on the Adequacy of Dialysis

Project managersDr M. van Diepen, Prof. dr F.W. Dekker 

Dept. of Nephrology, dept. of Medical Statistics of the Leiden University Medical Center, several research groups in The Netherlands and abroad

The NECOSAD study is a multicenter prospective follow-up study among end-stage renal disease (ESRD) patients new on dialysis. The aims of the NECOSAD study are 1) to monitor the quality and adequacy of dialysis treatment in the Netherlands and to provide evidence for the development and testing of guidelines, and 2) to study the effect of (genetic) cardiovascular risk factors. Outcome parameters are mortality, morbidity, and health-related quality of life.

NECOSAD is a collaborative study of the Leiden University Medical Center with many dialysis centers in The Netherlands. In the years 1997-2006, about 2000 patients have been included from 38 out of 49 dialysis centers in the Netherlands; maximum follow-up time is 10 years. 

Within the NECOSAD study, there are several research areas. At the department of Clinical Epidemiology in the LUMC, we focus on:

  1. genetic and other risk factors for cardiovascular disease and patient outcome
  2. nutritional status and survival
  3. quality of life and psychosocial aspects
  4. treatment comparisons (HD, APD, CAPD)

NECOSAD participated in the GENomic StratEgies for Treatment and Prevention of Cardiovascular Death in Uraemia and End-stage REnal Disease (GENECURE) project that aims to link existing European initiatives into a joint infrastructure for collaborative genetic studies in renal populations (, and in the FP7 funded EPOCAN-project (

Results of NECOSAD have lead to several publications: