Overview of published theses of the Clinical Epidemiology


Daniel Dias Ribeiro
Risk factors for first and recurrent venous thrombosis. New insights from old concepts.

Alberto Maino 
New insights in the risk profile for arterial thrombosis - differences and similarities in risk and prognostic factors between myocardial infarction and ischaemic stroke.

Vania Maris Morelli 
Cardiometabolic risk factors and venous thrombosis.

Camila Caram-Deelder 
The bright and the dark side of blood transfusion - turning data into knowledge.


A.G.C. (Anna) Boef 
Obtaining causal estimates of therapeutic effects in observational studies: the usefulness and validity of physician’s preference as an instrumental variable.

K.B. (Karin) Gast
Insulin resistance and atherosclerosis: the role of visceral fat. 

J.F. (Jasmijn) Timp
Risk factors and predictors of recurrent venous thrombosis. Building blocks for a prognostic model. 

A.W. (Willemien) Visser
Risk factors and outcome measures in hand and knee osteoarthritis.


M.J. (Marissa) Engbers 
Conventional and age-specifick risk factors for venous thrombosis in older people. The AT-AGE study. 

S. (Stefanie) Hillebrand
The role of the autonomic nervous system in diabetes and cardiovascular disease.

G. (Gürbey) Ocak
Vascular complications in kidney disease.

M.M. (Marit) Suttorp

Mortality and cardiovascular complications with erythropoiesis-stimulating agent treatment.


T.N. (Tobias) Bonten 
Time for aspirin: Blood pressure and platelet reactivity.

J. (Jan) Debeij
The effect of thyroid hormone on haemostasis and thrombosis.

C.L. (Christiaan) Meuwese
Nontraditional cardiovascular risk factors in end-stage renal disease.

M. (Marjolein) Raps 
Effectiveness and side effects of hormonal contraceptives.

R.E.J. (Rachel) Roach
Sex-specific aspects of venous thrombosis.


L.E. (Linda) Flinterman
Risk factors for a first and recurrent venous thrombosis.

W.Y. (Wing Yee) Kwok  
Clinical aspects of hand osteoarthritis: are erosions of importance?

B. (Bob) Siegerink
Prothrombotic factors and the risk of myocardial infarction and ischaemic stroke in young women; differences, similarities and implications.

B.H. (Bernardine) Stegeman
Hormonal contraceptives & venous thrombosis .

E. (Erlangga) Yusuf
On how obesity links with osteoarthritis.

S. (Saurabh) Zalpuri
R-fact study: risk factors for alloimmunization after red blood cells transfusions: methodology, risk factors and challenges in transfusion medicine research.


J. (Jessica) Bijsterbosch
Hand osteoarthritis: natural course and determinants of outcome.

K. (Kirsten) van Langevelde  
Are pulmonary embolism and deep-vein thrombosis always one disease?

L.A. (Luca) Lotta
Pathophysiology of thrombotic thrombocytopenic purpura: The "two-hit"paradigm.

A. Taher & K. Musallam
β-Thalassemia Intermedia. Morbidity Uncovered .


S.C. (Sandrin) Bergheanu
New Insights in Mechanism, Diagnosis and Treatment of Myocardial Infarction.

R.A. (Rutger) Middelburg
Transfusion-related acute lung injury Etiological research and its methodological challenges.

E.K. (Eva) Rombouts
Vitamin K and stability of oral anticoagulant therapy.

J.D. (Jaap-Jan) Snoep
Platelet reactivity and cardiovascular events.


S.C. (Sverre) Christiansen
Clinical and biochemical risk factors for first and recurrent episodes of venous thrombosis.

C. (Christiane) Drechsler
Metabolic alterations in dialysis patients.

M.E. (Mirjam) Meltzer
The role of the fibrinolytic system in arterial and venous thrombosis.

H.A.A.M. (Huib) van Vliet
Hormonal Contraceptives: Effectiveness and Adverse Effects.


I.D. (Irene) Bezemer
Genetic variation and susceptibility to venous thrombosis: Etiology and risk assessment.

A.M. (Anne Margriet) Euser
Long-term consequences of early growth and related epidemiological aspects.

S. (Saskia) Kuipers
Air Travel and Venous Thrombosis, Results of the WRIGHT study - Part I: Epidemiology.

Y. (Yvonne) van Leeuwen
Towards Improvement of Oral Anticoagulant Therapy.

R. (Renée) de Mutsert
Nutritional status in chronic dialysis patients: Associations with development of disease and survival.

A.J.M. (Anja) Schreijer
Air travel and venous thrombosis Results of the WRIGHT study - Part II: Mechanism.

M.Y.S. (Melissa) Thong
Living with dialysis: Patients' perceptions and outcomes.


A.Y. (Yael) Nossent
Determinants of Plasma levels of von Willebrand Factor and Coagulation.

E.R. (Elisabeth) Pomp
Lifestyle and venous thrombosis.

K.J. (Karlijn) van Stralen
Physical activity, immobilization and the risk of venous thrombosis.

L.W. (Lidwine) Tick
Diagnosis of venous thromboembolism and the post-thrombotic syndrome.


S.A. (Stella) Botha-Scheepers
Assessement and determinants of disease progression in osteoarthritis at multiple sites.

M.J.J. (Martijn) Finken
Preterm birth, early growth and adult metabolic health.

S. (Shirley) Uitte de Willige
Novel genetic risk factors for venous thrombosis.


A.P.A. (Alain) Gadisseur:
Improving the quality of oral anticoagulant therapy.

I.W.M.C. (Inez) van Korlaar:
Venous thrombosis. A patient's view.

N. (Nagmeh) Riyazi:
Familial osteoarthritis.

C.J. (Jan-Kees) van Rooden:
Risk assessment of thrombosis associated with central venous catheters.


J.W. (Jeanette) Blom:
Malignancy and venous thrombosis.

I. (Iris) Plug:
Hemophilia on the threshold of the 21st century.

M. (Marieke) Torn:
Optimal oral anticoagulant treatment for the prevention of arterial thrombosis.

C.Y. (Carla) Vossen:
Genetic risk factors for venous thrombosis: key players or minor risk modifiers?


A. (Astrid) van Hylckama Vlieg:
Causes of venous thrombosis.

B.C. (Bea) Tanis:
Arterial thrombosis in young women: role of oral contraceptives and coagulation factors.

M.C.H. (Marieke) de Visser:
Activated protein C resistance in the absence of factor V Leiden: Causes and thrombosis risk.


B.A. (Brigit) de Jong:
Immunologic and Genetic Risk Factors for Multiple Sclerosis.

F.J.A. (Fernie) Penning-van Beest:
Overanticoagulation on coumarin anticoagulants.

A. (Alexandr) Srámek:
Defects in haemostasis and the development of atherosclerosis.

D.P. (Darian) Shackleton:
Living with epilepsy: long term prognosis and psychosocial outcomes.


M.W. (Michiel) van der Linden:
Genetic risk factors for generalized and cutaneous lupus erythematosus (SLE).


C.J.M. (Carine) Doggen:
Genetic variation of clotting factors and the risk of myocardial infarction. Study of Myocardial Infarction Leiden (SMILE).

P.W. (Pieter-Willem) Kamphuisen:
High levels of factor VIII and the risk of venous thrombosis.


K.W.M. (Kitty) Bloemenkamp:
Oral contraceptives, venous thrombosis and the role of coagulation defects.

H.H. (Hester) van Boven:
Inherited antithrombin deficiency. A family study of natural history and risk factors.

R.P.M. (Ruud) Lensen:
Factor V Leiden: a study of thrombogenicity in differently selected families.

F.J.M. (Felix) van der Meer:
Risk of hemorrhage in oral anticoagulant therapy.

S. Siesling:
Huntington's disease: clinical, genetical and epidemiological aspects.

T. Wiersma:
Twee eeuwen zoeken naar medische bewijsvoering. De gespannen verhoudingen tussen experimentele fysiologie en klinische epidemiologie.


E.T.M. (Elysee) Hille:
"The Family Tree Mortality Ratio": a study of the natural history of hereditary disorders in past and present.


J.K. Sont:
Airways inflammation and its Sequellae in Asthma. Therapeutic implications.


S.C. (Suzanne) Cannegieter:
Optimal oral anticoagulant therapy in patients with mechanical heart valves.

E.K. George:
Childhood coeliac disease in the Netherlands; epidemiological aspects and associated disorders.

M. Triemstra:
Medical and psychosocial aspects of haemophilia.


T. (Ted) Koster:
Deep-vein thrombosis, a population-based case-control study: Leiden Thrombophilia Study (LETS).

R.J. Schlemper:
Dyspepsia and sero-epidemiology of gastritis in Dutch and Japanese populations.


M. Janssen:
NSAID-associated upper gastro-intestinal damage in patients with rheumatoid arthritis. Factors affecting the frequency of complaints and complications.

F. van Leeuwen:
Second malignancy as a sequel to cancer treatment: an assessment of risk.


B.J. Burger:
Congenital dislocation and dysplasia of the lip.

H.A. Smit:
Work related hand dermatitis: Epidemiological studies in occupational dermatitis.


J.N. Bouwes Bavinck:
Risk of skin cancer in renal-transplant recipients.

C.J.A. Roeleveld:
Mental retardation and parental occupation: a epidemiologic study.

A.C. Tersmette:
The long-term prognosis of partial gastrectomy for benign conditions.

D. van Zeben:
Severity and prognosis in rheumatoid arthritis; a follow-up of women with rheumatoid arthritis of recent onset.


G. Collée:
Clinical syndromes in low back pain.

E.G. Schouten:
Electrocardiographic indicators of autonomic balance and mortality.


J.M.W. Hazes:
Conception, contraception and rheumatoid arthritis. Reproductive variables studied in relation to genetic susceptibility.

J.H.M. Zwetsloot-Schonk:
Hospital data bases and decision analysis in evaluating procedures. Application in clinical oncology.


A.M. van Hemert:
Epidemiology of Osteoporosis and Prediction of Fractures.

*F.R. Rosendaal:
Hemophilia: the best of times, the worst of times.


*J.P. Vandenbroucke:
Oral contraceptives and rheumatoid arthritis. Further epidemiologic evidence for a protective effect.