Prof. dr J.P. Vandenbroucke (Jan)




Jan P Vandenbroucke was trained as a specialist in internal medicine at the University of Leuven, Belgium. In 1979 he obtained a Master of Science in Epidemiology at the Harvard School of Public Health, USA, and in 1981 a PhD at Erasmus University Rotterdam, the Netherlands. He was professor of Clinical Epidemiology at Leiden University Medical Center, the Netherlands (1986-2015). 

For the past 30 years he was mainly involved in the conduct of observational studies; his main interest is the application of epidemiologic methods to problems of aetiology and pathogenesis that are investigated in academic medical centres. In 2002-2003 he held a sabbatical at Oxford, UK. He was appointed as an Academy Professor by the Royal Netherlands Academy of Arts and Sciences (2006-2015), and as a Professor of Clinical Epidemiology at Aarhus University, Denmark, in 2014. He is a Fellow of the Royal Colleges of Physicians of London and Edinburgh. He serves on the international advisory board of The Lancet, and was a co-author of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. He was appointed as a Honorary Professor at the London School of Hygiene and Tropical Medicine in 2015.


Key Publicaties

  • Vandenbroucke JP, Pearce N. From ideas to studies: how to get ideas and 10.2147/CLEP.S142940. eCollection 2018. PubMed PMID: 29563838; PubMed Central sharpen them into research questions. Clin Epidemiol. 2018 Mar 6;10:253-264.
  • Vandenbroucke JP. Clinical epidemiology: A daydream? Eur J Epidemiol. 2017 Feb;32(2):95-101. doi: 10.1007/s10654-017-0226-2. Epub 2017 Jan 24. PubMed PMID: 28120285; PubMed Central PMCID: PMC5374175.
  • Vandenbroucke JP, Broadbent A, Pearce N. Causality and causal inference in epidemiology: the need for a pluralistic approach. Int J Epidemiol. 2016 Dec 1;45(6):1776-1786. doi: 10.1093/ije/dyv341. PubMed PMID: 26800751; PubMed Central PMCID: PMC5841832.
  • Snoep JD, Morabia A, Hernández-Díaz S, Hernán MA, Vandenbroucke JP. Commentary: A structural approach to Berkson's fallacy and a guide to a history of opinions about it. Int J Epidemiol. 2014 Apr;43(2):515-21. doi: 10.1093/ije/dyu026. Epub 2014 Feb 28. PubMed PMID: 24585735; PubMed Central PMCID: PMC3997377.
  • Vandenbroucke JP, Pearce N. Case-control studies: basic concepts. Int J Epidemiol. 2012 Oct;41(5):1480-9. doi: 10.1093/ije/dys147. PubMed PMID: 23045208. 
  • Vandenbroucke JP, Pearce N. Incidence rates in dynamic populations. Int J Epidemiol. 2012 Oct;41(5):1472-9. doi: 10.1093/ije/dys142. PubMed PMID: 23045207; PubMed Central PMCID: PMC3465772.
  • Vandenbroucke JP. Why do the results of randomised and observational studies differ? BMJ. 2011 Nov 7;343:d7020. doi: 10.1136/bmj.d7020. PubMed PMID: 22065658. 
  • von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007 Oct 20;370(9596):1453-7. PubMed PMID: 18064739.
  • Vandenbroucke JP. What is the best evidence for determining harms of medical treatment? CMAJ 2006; 174: 645-646.
  • Vandenbroucke JP. When are observational studies as credible as randomised trials? Lancet 2004; 363: 1728-1731. 
  • Vandenbroucke JP, de Craen AJ. Alternative medicine: a "mirror image" for scientific reasoning in conventional medicine. Ann Intern Med. 2001; 135: 507-13.
  • Vandenbroucke JP. In defense of case reports and case series. Ann Intern Med 2001; 134: 330-4.
  • Vandenbroucke JP, Rosendaal FR, Helmerhorst FM, Bloemenkamp KWM, Middeldorp S, Bouma BN, Rosing J. Oral contraceptives and the risk of venous thrombosis. N Engl J Med 2001; 344: 1527-1535.
  • Vandenbroucke JP, Koster T, Briët E, Reitsma PH, Bertina RM, Rosendaal FR. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344: 1453-1457.

Publicaties op PubMed van J.P. Vandenbroucke


Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden
Tel: +31 71 526 4037

Postzone C7-P
Postbus 9600
2300 RC Leiden