Prof. dr G. Kloppenburg (Margreet)



  • Osteoarthritis
  • Clinimetrics
  • Hand osteoarthritis
  • Rheumatology


Margreet Kloppenburg studied medicine at the University of Groningen, and obtained her medical degree in 1991.

She obtained her PhD degree in 1996 on the thesis "The tetracycline derivative minocycline as treatment for rheumatoid arthritis" at the Leiden University. Professor Kloppenburg got her qualification as a rheumatologist in 2000.

Since 2000 she is appointed both at the departments of Rheumatology (head: Prof. dr. TWJ Huizinga) and of Clinical Epidemiology (head: Prof. dr. FR Rosendaal) of the LUMC. She set up research in the field of osteoarthritis and has special interest for hand osteoarthritis.

In 2012 she was appointed professor in Rheumatology with focus on aetiology and clinimetrics. Her current research focuses on aetiological factors for osteoarthritis development and progression and on methodology to evaluate the course of osteoarthritis by MRI and radiographs and on patient reported outcomes.


Key Publicaties

  • Klein-Wieringa IR, Andersen SN, Kwekkeboom JC, Giera M, de Lange-Brokaar BJ, van Osch GJ, Zuurmond AM, Stojanovic-Susulic V, Nelissen RG, Pijl H, Huizinga TW, Kloppenburg M, Toes RE, Ioan-Facsinay A. Adipocytes Modulate the Phenotype of Human Macrophages through Secreted Lipids. J Immunol. 2013;191:1356-63.
  • Kortekaas MC, Kwok WY, Reijnierse M, Huizinga TW, Kloppenburg M. In erosive hand osteoarthritis more inflammatory signs on ultrasound are found than in the rest of hand osteoarthritis. Ann Rheum Dis 2013;72:930-4.
  • Kloppenburg M, Kwok WY. Hand osteoarthritis-a heterogeneous disorder. Nat Rev Rheumatol. 2011;8(1):22-31.
  • Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, Yusuf E, Kwekkeboom JC, El-Bannoudi H, Nelissen RG, Zuurmond A, Stojanovic-Susulic V, Van Osch GJ, Toes RE, Ioan-Facsinay A. The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis. 2011;70:851-7.
  • Kwok WY, Vliet Vlieland TP, Rosendaal FR, Huizinga TW, Kloppenburg M. Limitations in daily activities are the major determinant of reduced health-related quality of life in patients with hand osteoarthritis. Ann Rheum Dis 2011;70:334-6.
  • Bijsterbosch J, Watt I, Meulenbelt I, Rosendaal FR, Huizinga TW, Kloppenburg M. Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years. Ann Rheum Dis 2011;70:68-73.
  • Yusuf E, Nelissen R, Ioan-Fascinay A, Stojanovic-Susulic V, Degroot J, van Osch G, Middeldorp S, Huizinga T, Kloppenburg M. Association between weight or Body Mass Index and hand osteoarthritis: a systematic review. Ann Rheum Dis. 2010;69:761-5.
  • Botha-Scheepers S, Watt I, Rosendaal FR, Breedveld FC, Hellio le Graverand MP, Kloppenburg M. Changes in outcome measures for impairment, activity limitation, and participation restriction over two years in osteoarthritis of the lower extremities. Arthritis Rheum. 2008;59:1750-5.
  • Kornaat PR, Bloem JL, Ceulemans RYT, Riyazi N, Rosendaal FR, Nelissen RG, Carter WO, Hellio le Graverand MP, Kloppenburg M. Osteoarthritis of the knee: association between clinical features and MR imaging findings. Radiology 2006; 239: 811-817.
  • Riyazi N, Meulenbelt I, Kroon HM, Ronday HK, Hellio le Graverand MP, Rosendaal FR, Breedveld FC, Slagboom E, Kloppenburg M. Evidence for familial aggregation of hand, hip and spine but not knee osteoarthritis in siblings with miltiple joint involvement: the GARP study. Ann Rheum Dis 2005; 64: 438-443.


Publicaties op PubMed van G. Kloppenburg


Leids Universitair Medisch Centrum
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