Dr. Mariette Boon

Specialist interne geneeskunde in opleiding

Vakgebied(en)

  • Endocrinologie

Introductie

Mariëtte Boon (1988) heeft geneeskunde en biomedische wetenschappen gestudeerd en is aan de afdeling Interne geneeskunde cum laude (2014) gepromoveerd. Momenteel volgt ze een opleiding tot specialist interne geneeskunde (HMC +) en combineert ze onderzoek met klinische training.


Opleiding en prijzen

Mariëtte Boon heeft tijdens haar doctoraatsopleiding een interdisciplinaire onderzoekslijn opgezet over de biologie van bruin vet en het therapeutische potentieel ervan. Ze ontving verschillende onderzoekssubsidies, waaronder subsidies van de Raad van Bestuur van het LUMC, Diabetesfonds Nederland, NWO-Rubicon, RICS en European Foundation for the Study of Diabetes (EFSD). Verder heeft ze verschillende prijzen gewonnen voor haar onderzoek, waaronder de prestigieuze Heineken Young Scientist Award for Medicine 2016 en de Gratama Science Award 2019. Ze heeft tot nu toe 6 promovendi begeleid en heeft meer dan 70 papers gepubliceerd, onder meer in de wetenschappelijke bladen Nat Med, Nat Commun, Diabetes, Diabetologia en Cell Metab. Ze is een van de oprichters en voormalig voorzitter van de ‘Young Dutch Society for Endocrinology’. Samen met prof. Liesbeth van Rossum (Erasmus MC) schreef ze de bestseller 'VET belangrijk', een boek voor het lekenpubliek over de werking van lichaamsvet en hoe je overgewicht en obesitas effectief kunt bestrijden. In 2020 verschijnt dit boek in 10 landen.


Research

Boons research mainly focuses on strategies to increase energy expenditure in order to combat obesity and associated disorders. She has specific interest in the effects on energy-combusting brown adipose tissue (BAT), studying both cold exposure and druggable targets. In preclinical models, she discovered several pharmacological strategies that enhance BAT activity and energy expenditure resulting in a reduction of obesity and improved glucose and lipid metabolism (2,3). Furthermore, she recently showed that human BAT can be pharmacologically activated by GLP-1R agonism (8). She also revealed that Dutch South Asians have less BAT, which may partly underlie their susceptibility to become obese and develop type 2 diabetes and cardiovascular disease (1). In addition, she studies the bidirectional interaction between the immune system and energy metabolism. For instance, she has shown that South Asians have lower expression of genes involved in interferon signalling in skeletal muscle and white adipose tissue, which may contribute to increased insulin resistance in this vulnerable population (5). Overall, the goals of her present studies are 1) To identify novel pharmacological strategies to enhance energy metabolism in humans with special focus on BAT; 2) To study whether pharmacological activation and/or recruitment of BAT in overweight pre-diabetic individuals improves whole-body metabolism and reduces metabolic disturbances including dyslipidemia; 3) To assess novel noninvasive tools to assess BAT activity and/or volume in humans; 4) To gain further insight on the bidirectional interaction between energy metabolism and the immune system by performing cold exposure and pharmacological intervention studies.

Selected publications

1) Bakker LEH & Boon MR et al: Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study. Lancet Diabetes Endocrinol 2014; 2: 210-217
2) Boon MR & Berbée JFP & Khedoe PPSJ & Bartelt A et al: Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 2015; 6:6356
3) Van Dam AD et al: Salsalate activates brown adipose tissue in mice. Diabetes 2015;64: 1544-54.
4) Boon MR et al: Tracing human brown fat. Nat Med 2015; 21: 667-668
5) Van Dam AD et al: South Asians have lower expression of interferon signalling genes in white adipose tissue and skeletal muscle compared to white Caucasians. Diabetologia 2017, 60: 2525-2528
6) Nahon KJ et al: Effect of sitagliptin on energy metabolism and brown adipose tissue in overweight individuals with prediabetes: randomised placebo-controlled trial. Diabetologia 2018, 61: 2386-23975
7) Boon MR et al: Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study. Diabetologia 2019, 62: 112-122
8) Janssen LFM et al: Twelve weeks of Exenatide exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue in nondiabetic males. Metabolism 2020, in press


Weblinks


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden

Postbus 9600
2300 RC Leiden