Dr. Anne-Marie Cleton-Jansen

Associate Professor



Anne-Marie Cleton-Jansen (PhD) is molecular biologist specialized in molecular tumor genetics and tumor cell biology. Her research is focused on osteosarcoma, especially model systems and genome wide genomic profiling. A model system has been developed to study the development of osteosarcomas in model organisms starting from normal mesenchymal stem cells. This has led to the identification of genetic alterations that are recurring during malignant transformation. Furthermore the analysis of genome wide mRNA expression profiles in bone tumours has identified prognostic and diagnostic markers and putative targets for therapy. 

She is in charge of the technology platforms workpackage in the EuroBoNeT European network of excellence on the Pathology, genetics and biology of primary bone tumors. These platforms are dedicated to the development and performance of molecular technology especially for bone tumours.

Activities & Projects


Chair of the Dutch Cancer Society Community for Tumor Cell Biology

Work package leider in het Eurobonet Network of Excellence WP5.2: “Technology Platforms”

Member of the ATCC® Standards Development Organization


KWF Kankerbestrijding. A.M.Cleton-Jansen, P.C.W. Hogendoorn. Signal transduction pathways in skeletal differentiation as therapeutic targets for high grade central osteosarcoma 

KWF Kankerbestrijding. P.C.W. Hogendoorn, J.V.G.M. Bovée, A.M.Cleton-Jansen. UL 2002-2738. Expression profiling of peripheral chondrosarcoma progression: towards molecular understanding for diagnostic tools Association of

International Cancer Research. A.M.Cleton-Jansen. Grant no. 00-258. Identification of E-cadherin mediated expression patterns involved in the development of lobular breast cancer 

KWF Kankerbestrijding, A.M.Cleton-Jansen, C.J.Cornelisse, G.J.B. van Ommen. RUL 2000-2205.Expression-based positional cloning of breast tumour suppressor genes on chromosome arm 16q



Selected publications

  • Mohseny,A.B., Tieken,C., van der Velden,P.A., Szuhai,K., de,A.C., Hogendoorn,P.C., and Cleton-Jansen,A.M. (2010). Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma. Genes Chromosomes Cancer 49, 1095-1103.
  • Cai,Y., Mohseny,A.B., Karperien,M., Hogendoorn,P.C., Zhou,G., and Cleton-Jansen,A.M. (2010). Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J. Pathol. 220, 24-33.
  • Cleton-Jansen,A.M., Anninga,J.K., Briaire-de Bruijn,I.H., Romeo,S., Oosting,J., Egeler,R.M., Gelderblom,H., Taminiau,A.H., and Hogendoorn,P.C. (2009). Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. Br. J. Cancer 101, 1909-1918.
  • Mohseny,A.B., Szuhai,K., Romeo,S., Buddingh,E.P., Briaire-de,B., I, de,J.D., van,P.M., Cleton-Jansen,A.M., and Hogendoorn,P.C. (2009). Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. J. Pathol. 219, 294-305.
  • Cleton-Jansen,A.M., Callen,D.F., Seshadri,R., Goldup,S., Mccallum,B., Crawford,J., Powell,J.A., Settasatian,C., van,B.H., Moerland,E.W., Smit,V.T., Harris,W.H., Millis,R., Morgan,N.V., Barnes,D., Mathew,C.G., and Cornelisse,C.J. (2001). Loss of heterozygosity mapping at chromosome arm 16q in 712 breast tumors reveals factors that influence delineation of candidate regions. Cancer Res. 61, 1171-1177.
  • Gomes,C.M., Welling,M., Que,I., Henriquez,N.V., van der Pluijm,G., Romeo,S., Abrunhosa,A.J., Botelho,M.F., Hogendoorn,P.C., Pauwels,E.K., and Cleton-Jansen,A.M. (2007). Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi. Eur. J. Nucl. Med. Mol. Imaging 34, 1793-1803.
  • Hameetman,L., Szuhai,K., Yavas,A., Knijnenburg,J., van,D.M., van,D.H., Taminiau,A.H., Cleton-Jansen,A.M., Bovee,J.V., and Hogendoorn,P.C. (2007). The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions. J. Natl. Cancer Inst. 99, 396-406.
  • Liefers,G.J., Tollenaar,R.A., and Cleton-Jansen,A.M. (1999). Molecular detection of minimal residual disease in colorectal and breast cancer. Histopathology 34, 385-390.
  • Fanconi anaemia/Breast cancer consortium. (1996). Positional cloning of the Fanconi anaemia group A gene. Nat. Genet. 14, 324-328.
  • Wooster,R., Cleton-Jansen,A.M., Collins,N., Mangion,J., Cornelis,R.S., Cooper,C.S., Gusterson,B.A., Ponder,B.A., von,D.A., Wiestler,O.D., and . (1994). Instability of short tandem repeats (microsatellites) in human cancers. Nat. Genet. 6, 152-156.


Leids Universitair Medisch Centrum
Gebouw 1
Kamer P1-30

Albinusdreef 2
2333 ZA Leiden
Tel: 31 (0)71 5266515

Postzone L1-Q
Postbus 9600
2300 RC Leiden

E-mail: a.m.cleton-jansen@lumc.nl