- Genomics and genetics and molecular pathology of familial colorectal cancer
Tom van Wezel is a molecular biologist at the Department of Pathology of the LUMC. Research interests are the genomics and molecular pathology of inherited forms of cancer (with unknown causes), in particular familial colorectal cancer. Current methods include high-density SNP arrays, homozygosity mapping, exome and transcriptome profiling using deep-sequencing, allele-specific gene expression profiling, association and linkage studies.
The tumors from inherited cancer syndromes are rare, can be decades old and are mostly available as formalin fixed-paraffin embedded (FFPE) tissue. An important aspect of the research is to optimize and modify genomics methods to allow the use of DNA/RNA isolated from FFPE tissue, and implement these methods in diagnostics.
2010-present Associate Professor, dept. of Pathology, LUMC
2003-2010 Assistant Professor, dept.of Pathology, LUMC
2000-2003 Postdoc, dept.of Pathology, LUMC
1998- 2000 Postdoc, section Genetics, Div. Molecular Genetics, NKI
1994-1998 PhD student, section Genetics (Dr. P. Demant), NKI
Leids Universitair Medisch Centrum
2333 ZA Leiden
Tel: 071 5266813
2300 RC Leiden