Resultaten en publicaties

Hieronder vindt u de lijst van wetenschappelijke artikelen die tot nu toe zijn voortgekomen uit de NEO studie. De proefschriften van NEO onderzoekers vindt u via het menu hiernaast. 

  1. de Mutsert R, den Heijer M, Rabelink TJ, Smit JW, Romijn JA, Jukema JW, de Roos A, Cobbaert CM, Kloppenburg M, le Cessie S, Middeldorp S, Rosendaal FR. The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection. Eur J Epidemiol. 2013 Jun;28(6):513-23. doi:10.1007/s10654-013-9801-3. Epub 2013 Apr 11.
  2. Gast KB, Smit JW, den Heijer M, Middeldorp S, Rippe RC, le Cessie S, de Koning EJ, Jukema JW, Rabelink TJ, de Roos A, Rosendaal FR, de Mutsert R; NEO study group. Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study. Atherosclerosis. 2013 Aug;229(2):423-9. doi:10.1016/j.atherosclerosis.2013.05.021. Epub 2013 Jun 1.
  3. Claessen KM, Appelman-Dijkstra NM, Pereira AM, Joustra SD, de Mutsert R, Gast KB, den Heijer M, Smit JW, Dekkers OM, Biermasz NR. Abnormal metabolic phenotype in middle-aged GH-deficient adults despite long-term recombinant human GH replacement. Eur J Endocrinol. 2013 Dec 21;170(2):263-72. doi:10.1530/EJE-13-0764. Print 2014 Feb.
  4. Visser AW, de Mutsert R, Loef M, le Cessie S, den Heijer M, Bloem JL, Reijnierse M, Rosendaal FR, Kloppenburg M; NEO Study Group. The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study. Osteoarthritis Cartilage. 2014 Feb;22(2):197-202. doi:10.1016/j.joca.2013.12.002. Epub 2013 Dec 12.
  5. Visser AW, Ioan-Facsinay A, de Mutsert R, Widya RL, Loef M, de Roos A, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M; NEO Study Group. Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study. Arthritis Res Ther. 2014 Jan 22;16(1):R19. doi: 10.1186/ar4447.
  6. Hillebrand S, de Mutsert R, Christen T, Maan AC, Jukema JW, Lamb HJ, de Roos A, Rosendaal FR, den Heijer M, Swenne CA; NEO Study Group. Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation. Obesity (Silver Spring). 2014 Jun;22(6):1553-9. doi:10.1002/oby.20709. Epub 2014 Feb 18.
  7. Lee DH, Dane MJ, van den Berg BM, Boels MG, van Teeffelen JW, de Mutsert R, den Heijer M, Rosendaal FR, van der Vlag J, van Zonneveld AJ, Vink H, Rabelink TJ; NEO study group. Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion. PLoS One. 2014 May 9;9(5):e96477. doi: 10.1371/journal.pone.0096477. eCollection 2014.
  8. Visser AW, de Mutsert R, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M; NEO Study Group. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann Rheum Dis. 2015 Oct;74(10):1842-7. doi: 10.1136/annrheumdis-2013-205012. Epub 2014 May 20.
  9. Hillebrand S, Swenne CA, Gast KB, Maan AC, le Cessie S, Jukema JW, Rosendaal FR, den Heijer M, de Mutsert R. The role of insulin resistance in the association between body fat and autonomic function. Nutr Metab Cardiovasc Dis. 2015 Jan;25(1):93-9. doi: 10.1016/j.numecd.2014.07.009. Epub 2014 Aug 1.
  10. Thijs W, de Mutsert R, le Cessie S, Hiemstra PS, Rosendaal FR, Middeldorp S, Rabe KF. Reproducibility of exhaled nitric oxide measurements in overweight and obese adults. BMC Res Notes. 2014 Nov 3;7(1):775. doi: 10.1186/1756-0500-7-775.
  11. Visser AW, de Mutsert R, Bloem JL, Reijnierse M, Kazato H, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M; Netherlands Epidemiology of Obesity Study Group.  Do knee osteoarthritis and fat-free mass interact in their impact on health-related quality of life in men? Results from a population-based cohort. Arthritis Care Res (Hoboken). 2015 Jul;67(7):981-8. doi: 10.1002/acr.22550.
  12. Stomp W, Reijnierse M, Kloppenburg M, de Mutsert R, Bovée JV, den Heijer M, Bloem JL; NEO study group. Prevalence of cartilaginous tumours as an incidental finding on MRI of the knee. Eur Radiol. 2015 Dec;25(12):3480-7. doi:10.1007/s00330-015-3764-6. Epub 2015 May 21.
  13. Gast KB, den Heijer M, Smit JW, Widya RL, Lamb HJ, de Roos A, Jukema JW, Rosendaal FR, de Mutsert R; NEO study group. Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study. Atherosclerosis. 2015 Aug;241(2):547-54. doi: 10.1016/j.atherosclerosis.2015.05.026. Epub 2015 Jun 3.
  14. Mook-Kanamori DO, de Mutsert R, Rensen PC, Prehn C, Adamski J, den Heijer M, le Cessie S, Suhre K, Rosendaal FR, Dijk KW.  Type 2 diabetes is associated with postprandial amino acid measures. Arch Biochem Biophys. 2015 Aug 10. pii: S0003-9861(15)30029-1. doi: 10.1016/j.abb.2015.08.003. Epub 2015 Aug 10.
  15. Blauw LL, Boon MR, Rosendaal FR, de Mutsert R, Gast KB, van Dijk KW, Rensen PC, Dekkers OM; NEO study group. Smoking is associated with increased resting energy expenditure in the general population: The NEO study. Metabolism. 2015 Nov;64(11):1548-55. doi: 10.1016/j.metabol.2015.08.008. Epub 2015 Aug 18.
  16. de Boer AW, de Mutsert R, den Heijer M, Jukema JW, Rosendaal FR, Blom JW, Assendelft WJ; NEO study group. Overweight can be used as a tool to guide case-finding for cardiovascular risk assessment. Fam Pract. 2015 Dec;32(6):646-51. doi: 10.1093/fampra/cmv080. Epub 2015 Oct 17.
  17. de Boer AW, de Mutsert R, den Heijer M, Rosendaal FR, Jukema JW, Blom JW, Numans ME; NEO study group. Advantages and disadvantages of unstructured cardiovascular risk factor screening for follow-up in primary care. Eur J Prev Cardiol. 2016 Jul;23(11):1195-201. doi: 10.1177/2047487315618794. Epub 2015 Nov 24.
  18. Widya RL, de Mutsert R, den Heijer M, le Cessie S, Rosendaal FR, Jukema JW, Smit JW, de Roos A, Lamb HJ; NEO Study Group. Association between Hepatic Triglyceride Content and Left Ventricular Diastolic Function in a Population-based Cohort: The Netherlands Epidemiology of Obesity Study. Radiology. 2016 May;279(2):443-50. doi: 10.1148/radiol.2015150035. Epub 2016 Jan 26.
  19. Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, Wang Y, van Dijk KW, Rensen PC. Serum CETP concentration is not associated with measures of body fat: The NEO study. Atherosclerosis. 2016 Mar;246:267-73. doi:10.1016/j.atherosclerosis.2016.01.031. Epub 2016 Jan 19.
  20. van Leeuwen EM, et al. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J Med Genet. 2016 Jul;53(7):441-9. doi: 10.1136/jmedgenet-2015-103439. Epub 2016 Apr 1.
  21. Garessus ED, de Mutsert R, Visser AW, Rosendaal FR, Kloppenburg M. No association between impaired glucose metabolism and osteoarthritis. Osteoarthritis Cartilage. 2016 Sep;24(9):1541-7. doi: 10.1016/j.joca.2016.04.007. Epub 2016 Apr 12.
  22. Okbay A, et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016 Jun;48(6):624-33. doi:10.1038/ng.3552. Epub 2016 Apr 18. Erratum in: Nat Genet.  2016 Jul 27;48(8):970. Nat Genet. 2016 Nov 29;48(12 ):1591.
  23. Visser AW, Mertens B, Reijnierse M, Bloem JL, de Mutsert R, le Cessie S, Rosendaal FR, Kloppenburg M. Bakers' cyst and tibiofemoral abnormalities are more distinctive MRI features of symptomatic osteoarthritis than patellofemoral abnormalities. RMD Open. 2016 May 17;2(1):e000234. doi:10.1136/rmdopen-2015-000234. eCollection 2016.
  24. Polfus LM, et al. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. Am J Hum Genet. 2016 Sep 1;99(3):785. doi: 10.1016/j.ajhg.2016.08.002. Epub 2016 Sep 1.
  25. Horikoshi M, et al. Genome-wide associations for birth weight and correlations with adult disease. Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806. Epub 2016 Sep 28.
  26. Barban N, et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet. 2016 Dec;48(12):1462-1472. doi: 10.1038/ng.3698. Epub 2016 Oct 31.
  27. Wanders AJ, Alssema M, de Koning EJ, le Cessie S, de Vries JH, Zock PL, Rosendaal FR, Heijer MD, de Mutsert R. Fatty acid intake and its dietary sources in relation with markers of type 2 diabetes risk: The NEO study. Eur J Clin Nutr. 2017 Feb;71(2):245-251. doi: 10.1038/ejcn.2016.204. Epub 2016 Nov 9.
  28. Natarajan P, et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520. doi: 10.1161/CIRCGENETICS.116.001572. Epub 2016 Nov 21.
  29. Schmidt AF, et al. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105. doi: 10.1016/S2213-8587(16)30396-5. Epub 2016 Nov 29.
  30. Li M, et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017 Mar;28(3):981-994. doi: 10.1681/ASN.2016020131. Epub 2016 Dec 5.
  31. Floyd JS, et al. Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group. Pharmacogenomics J. 2016 Dec 13. doi: 10.1038/tpj.2016.90. Epub 2016 Dec 13.
  32. van Rooij FJ, et al. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 5;100(1):51-63. doi: 10.1016/j.ajhg.2016.11.016. Epub 2016 Dec 22.
  33. Noordam R, et al. A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and   QT   intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet. 2017 May;54(5):313-323. doi: 10.1136/jmedgenet-2016-104112. Epub 2016 Dec 30.
  34. Kroon FP, Ramiro S, Royston P, Le Cessie S, Rosendaal FR, Kloppenburg M. Reference curves for the Australian/Canadian Hand Osteoarthritis Index in the middle-aged Dutch population. Rheumatology (Oxford). 2017 May 1;56(5):745-752. doi: 10.1093/rheumatology/kew483.
  35. Warren HR, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017 Mar;49(3):403-415. doi: 10.1038/ng.3768. Epub 2017 Jan 30. Erratum in: Nat Genet. 2017 Sep 27;49(10):1558.
  36. Marouli E, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017 Feb 9;542(7640):186-190. doi: 10.1038/nature21039. Epub 2017 Feb 1.
  37. van den Berg ME, et al. Discovery of novel heart rate-associated loci using the Exome Chip. Hum Mol Genet. 2017 Jun 15;26(12):2346-2363. doi: 10.1093/hmg/ddx113.
  38. Day FR, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet. 2017 Jun;49(6):834-841. doi: 10.1038/ng.3841. Epub 2017 Apr 24.
  39. Lucassen EA, de Mutsert R, le Cessie S, Appelman-Dijkstra NM, Rosendaal FR, van Heemst D, den Heijer M, Biermasz NR; NEO study group. Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study. PLoS One. 2017 May 1;12(5):e0176685. doi: 10.1371/journal.pone.0176685. eCollection 2017.
  40. Bonten TN, Kasteleyn MJ, de Mutsert R, Hiemstra PS, Rosendaal FR, Chavannes NH, Slats AM, Taube C. Defining asthma-COPD overlap syndrome: a population-based study. Eur Respir J. 2017 May 1;49(5). pii: 1602008. doi: 10.1183/13993003.02008-2016. Print 2017 May.
  41. de Boer AW, Drewes YM, de Mutsert R, Numans ME, den Heijer M, Dekkers OM, de Roos A, Lamb HJ, Blom JW, Reis R. Incidental findings in research: A focus group study about the perspective of the research participant. J Magn Reson Imaging. 2017 May 4. doi: 10.1002/jmri.25739. Epub 2017 May 4.
  42. Dale CE, et al. Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Circulation. 2017 Jun 13;135(24):2373-2388. doi: 10.1161/CIRCULATIONAHA.116.026560. Epub 2017 May 12.
  43. Christen T, de Mutsert R, Gast KB, Rensen PCN, de Koning E, Rosendaal FR, Trompet S, Jukema JW. Association of fasting triglyceride concentration and postprandial triglyceride response with the carotid intima-media thickness in the middle aged: The Netherlands Epidemiology of Obesity study. J Clin Lipidol. 2017 Mar - Apr;11(2):377-385.e1. doi: 10.1016/j.jacl.2016.12.016. Epub 2017 Jan 23.
  44. Skaaby T, et al. Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep. 2017 May 22;7(1):2224. doi: 10.1038/s41598-017-01977-w.
  45. Elffers TW, de Mutsert R, Lamb HJ, Maan AC, Macfarlane PW, Willems van Dijk K, Rosendaal FR, Jukema JW, Trompet S. Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease. Diabetol Metab Syndr. 2017 May 22;9:40. doi: 10.1186/s13098-017-0238-9. eCollection 2017.
  46. Widya RL, de Mutsert R, Westenberg JJM, Gast KB, den Heijer M, le Cessie S, Smit JWA, Jukema JW, Rosendaal FR, de Roos A, Lamb HJ; NEO Study Group. Is Hepatic Triglyceride Content Associated with Aortic Pulse Wave Velocity and Carotid Intima-Media Thickness? The Netherlands Epidemiology of Obesity Study. Radiology. 2017 May 29:160916. doi: 10.1148/radiol.2017160916. Epub 2017 May 29.
  47. Blauw LL, Noordam R, Trompet S, Berbée JFP, Rosendaal FR, van Heemst D, van Dijk KW, Mook-Kanamori DO, de Mutsert R, Rensen PCN. Genetic variation in the obesity gene FTO is not associated with decreased fat oxidation: the NEOstudy. Int J Obes (Lond). 2017 Jun 19. doi: 10.1038/ijo.2017.146. Epub 2017 Jun 19.
  48. Bonten TN, de Mutsert R, Rosendaal FR, Jukema JW, van der Bom JG, de Jongh RT, den Heijer M. Chronic use of low-dose aspirin is not associated with lower bone mineral density in the general population. Int J Cardiol. 2017 Jun 27. pii: S0167-5273(17)32102-2. doi: 10.1016/j.ijcard.2017.06.089. Epub 2017 Jun 27.
  49. Seyerle AA, et al. Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J. 2017 Jul 18. doi: 10.1038/tpj.2017.10. Epub 2017 Jul 18.
  50. Wain LV, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09438. doi: 10.1161/HYPERTENSIONAHA.117.09438. [Epub ahead of print]
  51. Manousaki D, et al. Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. Am J Hum Genet. 2017 Aug 3;101(2):227-238. doi: 10.1016/j.ajhg.2017.06.014. Epub 2017 Jul 27. Erratum in: Am J Hum Genet. 2018 Dec 6;103(6):1053.
  52. Smith CE, et al. Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Mol Nutr Food Res. 2018 Feb;62(3). doi: 10.1002/mnfr.201700347. Epub 2017 Dec 11.
  53. Elffers TW, de Mutsert R, Lamb HJ, de Roos A, Willems van Dijk K, Rosendaal FR, Jukema JW, Trompet S. Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women. PLoS One. 2017 Sep 28;12(9):e0185403. doi: 10.1371/journal.pone.0185403. eCollection 2017.
  54. Strawbridge RJ, et al. Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. Atherosclerosis. 2017 Nov;266:196-204. doi: 10.1016/j.atherosclerosis.2017.09.031. Epub 2017 Sep 28.
  55. McKeown NM, et al. Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia. 2018 Feb;61(2):317-330. doi: 10.1007/s00125-017-4475-0. Epub 2017 Nov 2.
  56. Noordam R, Zwetsloot CPA, de Mutsert R, Mook-Kanamori DO, Lamb HJ, de Roos A, de Koning EJP, Rosendaal FR, Willems van Dijk K, van Heemst D. Interrelationship of the rs7903146 TCF7L2 gene variant with measures of glucose metabolism and adiposity: The NEO study. Nutr Metab Cardiovasc Dis. 2018 Feb;28(2):150-157. doi: 10.1016/j.numecd.2017.10.012. Epub 2017 Oct 18.
  57. Christen T, Trompet S, Noordam R, Blauw LL, Gast KB, Rensen PCN, Willems van Dijk K, Rosendaal FR, de Mutsert R, Jukema JW; NEO study. Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study. J Clin Lipidol. 2018 Jan - Feb;12(1):137-144.e1. doi: 10.1016/j.jacl.2017.10.023. Epub 2017 Nov 2.
  58. Kasteleyn MJ, Bonten TN, de Mutsert R, Thijs W, Hiemstra PS, le Cessie S, Rosendaal FR, Chavannes NH, Taube C. Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study. Respir Res. 2017 Dec 7;18(1):205. doi: 10.1186/s12931-017-0684-9.
  59. Li-Gao R, de Mutsert R, Rensen PCN, van Klinken JB, Prehn C, Adamski J, van Hylckama Vlieg A, den Heijer M, le Cessie S, Rosendaal FR, Willems van Dijk K, Mook-Kanamori DO. Postprandial metabolite profiles associated with type 2 diabetes clearly stratify individuals with impaired fasting glucose. Metabolomics. 2018;14(1):13. doi: 10.1007/s11306-017-1307-7. Epub 2017 Dec 12.
  60. Turcot V, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. Epub 2017 Dec 22. Erratum in: Nat Genet. 2018 Mar 16.
  61. Dekkers IA, de Mutsert R, de Vries APJ, Rosendaal FR, Cannegieter SC, Jukema JW, le Cessie S, Rabelink TJ, Lamb HJ, Lijfering WM. Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population. J Thromb Haemost. 2017 Dec 28. doi: 10.1111/jth.13935. Epub 2018 Jan 19.
  62. Rafiq R, Thijs W, Prein R, de Jongh RT, Taube C, Hiemstra PS, de Mutsert R, den Heijer M. Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population. Nutrients. 2018 Jan 3;10(1). pii: E35. doi: 10.3390/nu10010035.
  63. Medina-Gomez C, et. Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet. 2018 Jan 4;102(1):88-102. doi: 10.1016/j.ajhg.2017.12.005.
  64. Elffers TW, de Mutsert R, Lamb HJ, Maan AC, Macfarlane PW, Willems van Dijk K, Rosendaal FR, Jukema JW, Trompet S. Relation of Overall and Abdominal Adiposity With Electrocardiogram Parameters of Subclinical Cardiovascular Disease in Individuals Aged 45 to 65 Years (from the Netherlands Epidemiology of Obesity Study). Am J Cardiol. 2018 Mar 1;121(5):570-578. doi: 10.1016/j.amjcard.2017.11.030. Epub 2017 Dec 11.
  65. de Mutsert R, Gast K, Widya R, de Koning E, Jazet I, Lamb H, le Cessie S, de Roos A, Smit J, Rosendaal F, den Heijer M. Associations of Abdominal Subcutaneous and Visceral Fat with Insulin Resistance and Secretion Differ Between Men and Women: The Netherlands Epidemiology of Obesity Study. Metab Syndr Relat Disord. 2018 Feb;16(1):54-63. doi: 10.1089/met.2017.0128. Epub 2018 Jan 17.
  66. Li-Gao R, de Mutsert R, Rosendaal FR, Willems van Dijk K, Mook-Kanamori DO. The genetics of fasting and postprandial metabolite levels are overlapping. Physiol Genomics. 2018 Jan 26. doi: 10.1152/physiolgenomics.00101.2017. Epub 2018 Jan 26.
  67. Sung YJ, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Feb 13. pii: S0002-9297(18)30017-X. doi: 10.1016/j.ajhg.2018.01.015. Epub 2018 Feb 15.
  68. Dekkers IA, de Mutsert R, Rabelink TJ, Jukema JW, de Roos A, Rosendaal FR, Lamb HJ, de Vries APJ. Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study. Atherosclerosis. 2018 May;272:94-100. doi: 10.1016/j.atherosclerosis.2018.03.029. Epub 2018 Mar 16.
  69. Mahajan A, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet. 2018 Apr;50(4):559-571. doi: 10.1038/s41588-018-0084-1. Epub 2018 Apr 9.
  70. Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP, Wang Y, van Klinken JB, Christen T, van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Rensen PCN, Willems van Dijk K. CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease. Circ Genom Precis Med. 2018 May;11(5):e002034. doi: 10.1161/CIRCGEN.117.002034.
  71. Lin H, et al. Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval. Circ Genom Precis Med. 2018 May;11(5):e002037. doi: 10.1161/CIRCGEN.117.002037.
  72. Marees AT, et al. Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use. Drug Alcohol Depend. 2018 Jul 1;188:94-101. doi: 10.1016/j.drugalcdep.2018.03.026. Epub 2018 Apr 25.
  73. Irvin MR, Sitlani CM, Noordam R, Avery CL, Bis JC, Floyd JS, Li J, Limdi NA, Srinivasasainagendra V, Stewart J, de Mutsert R, Mook-Kanamori DO, Lipovich L, Kleinbrink EL, Smith A, Bartz TM, Whitsel EA, Uitterlinden AG, Wiggins KL, Wilson JG, Zhi D, Stricker BH, Rotter JI, Arnett DK, Psaty BM, Lange LA. Genome-wide meta-analysis of SNP-by9-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry. Pharmacogenomics J. 2018 Jun 1. doi: 10.1038/s41397-018-0021-9. [Epub ahead of print]
  74. Bihlmeyer NA, et al. ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circ Genom Precis Med. 2018 Jan;11(1):e001758. doi: 10.1161/CIRCGEN.117.001758. Erratum in: Circ Genom Precis Med. 2018 Sep;11(9):e000050.
  75. Feitosa MF, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One. 2018 Jun 18;13(6):e0198166. doi: 10.1371/journal.pone.0198166. eCollection 2018.
  76. Merino J, et al. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. 2018 Jul 9. doi: 10.1038/s41380-018-0079-4. [Epub ahead of print].
  77. Prins BP, et al. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biol. 2018 Jul 17;19(1):87. doi: 10.1186/s13059-018-1457-6.
  78. Verkouter I, Noordam R, de Roos A, Lamb HJ, Rosendaal FR, van Heemst D, de Mutsert R. Adult weight change in relation to visceral fat and liver fat at middle age: The Netherlands epidemiology of obesity study. Int J Obes (Lond). 2018 Jul 19. doi: 10.1038/s41366-018-0163-5. [Epub ahead of print].
  79. Wyss AB, et al. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nat Commun. 2018 Jul 30;9(1):2976. doi: 10.1038/s41467-018-05369-0.
  80. Christen T, Trompet S, Noordam R, van Klinken JB, van Dijk KW, Lamb HJ, Cobbaert CM, den Heijer M, Jazet IM, Jukema JW, Rosendaal FR, de Mutsert R. Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin. Peptides. 2018 Sep;107:25-31. doi: 10.1016/j.peptides.2018.07.008. Epub 2018 Aug 1.
  81. 't Hart LM, Vogelzangs N, Mook-Kanamori DO, Brahimaj A, Nano J, van der Heijden AAWA, Willems van Dijk K, Slieker RC, Steyerberg E, Ikram MA, Beekman M, Boomsma DI, van Duijn CM, Slagboom PE, Stehouwer CDA, Schalkwijk CG, Arts ICW, Dekker JM, Dehghan A, Muka T, van der Kallen CJH, Nijpels G, van Greevenbroek M. Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes. J Clin Endocrinol Metab. 2018 Aug 2. doi: 10.1210/jc.2018-01165. [Epub ahead of print].
  82. Jackson VE, et al. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018 Jan 12;3:4. doi: 10.12688/wellcomeopenres.12583.3. eCollection 2018.
  83. Elffers TW, Trompet S, de Mutsert R, Maan AC, Lamb HJ, Macfarlane PW, Rosendaal FR, Jukema JW. Borderline Q-waves in individuals without overt cardiovascular disease: Relations with adiposity, subclinical atherosclerosis and vascular stiffness. Int J Cardiol. 2019 Jan 1;274:331-336. doi: 10.1016/j.ijcard.2018.08.088. Epub 2018 Sep 1.
  84. Skaaby T, et al. Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction. 2019 Feb;114(2):216-225. doi: 10.1111/add.14438. Epub 2018 Oct 30.
  85. Evangelou E, et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 Oct;50(10):1412-1425. doi: 10.1038/s41588-018-0205-x. Epub 2018 Sep 17. Erratum in: Nat Genet. 2018 Dec;50(12):1755.
  86. Dekker SA, Noordam R, Biermasz NR, de Roos A, Lamb HJ, Rosendaal FR, Rensen PCN, van Heemst D, de Mutsert R. Habitual Sleep Measures are Associated with Overall Body Fat, and not Specifically with Visceral Fat, in Men and Women. Obesity (Silver Spring). 2018 Oct;26(10):1651-1658. doi: 10.1002/oby.22289.
  87. Bos MM, Noordam R, van den Berg R, de Mutsert R, Rosendaal FR, Blauw GJ, Rensen PCN, Biermasz NR, van Heemst D. Associations of sleep duration and quality with serum and hepatic lipids: The Netherlands Epidemiology of Obesity Study. J Sleep Res. 2018 Oct 15:e12776. doi: 10.1111/jsr.12776. [Epub ahead of print]
  88. Ji Y, et al. Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes. 2019 Jan;68(1):207-219. doi: 10.2337/db18-0708. Epub 2018 Oct 23.
  89. Blauw LL, Noordam R, Soidinsalo S, Blauw CA, Li-Gao R, de Mutsert R, Berbée JFP, Wang Y, van Heemst D, Rosendaal FR, Jukema JW, Mook-Kanamori DO, Würtz P, Willems van Dijk K, Rensen PCN. Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile. Eur J Hum Genet. 2018 Nov 12. doi: 10.1038/s41431-018-0301-5. [Epub ahead of print]
  90. Franceschini N, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.
  91. Giri A, et al. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet. 2019 Jan;51(1):51-62. doi: 10.1038/s41588-018-0303-9. Epub 2018 Dec 21.
  92. Kraja AT, et al. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet. 2019 Jan 3;104(1):112-138. doi:  10.1016/j.ajhg.2018.12.001. Epub 2018 Dec 27.
  93. Rafiq R, Walschot F, Lips P, Lamb HJ, de Roos A, Rosendaal FR, Heijer MD, de Jongh RT, de Mutsert R. Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations. Clin Nutr. 2018 Dec 18. pii: S0261-5614(18)32586-X. doi: 10.1016/j.clnu.2018.12.018. [Epub ahead of print]