‘Stress-related disorders across the life-span’

The aim of our research is to better understand the onset, course and chronicity of stress and trauma related psychiatric disorders across the life-span and to translate our findings into  personalised treatment and prevention for our patients and their families.

As a general background for our research we assume that the broad categories of mood, anxiety and trauma and stressor-related disorders in adults, as well as certain disruptive disorders in adolescents, share a dysregulation of  psychobiological stress-regulation systems in interaction with the environment.  The capacity to adapt to a wide range of psychosocial stressors shows considerable variation from one person to another. This is partly due to skills and experiences that are acquired in a caring and structured upbringing and partly due to biological (genetic) vulnerability or resilience of the stress-regulation systems. The transdiagnostic point of view entails that many of the stress-related disorders, usually considered separately in the common classification systems, are likely to share similar dysregulations.

Our research is part of the LUMC Medical Research profiles Translational Neuroscience’, Innovation in Health strategy and Quality of Care’ and Ageing’.  It is also embedded in the Leiden University Research Focus Areas ‘Brain Function and Dysfunction over the lifespan’ and ‘Health, Prevention and the Human Life Cycle’.  LUMC Psychiatry is a partner in various national and international innovative research projects.