Older patients are heterogeneous with respect to their vitality and vulnerability, level of functioning and quality of life. Their individual situation and wishes are especially important for older patients who need invasive treatment, such as chemotherapy, an operation or radiotherapy. For vulnerable patients additional preventive measures may be indicated, while other older patients may undergo procedures without extra measures. Not undergoing the procedure may be the best option to maintain quality of life in a small group of very vulnerable older patients. Ideally, the likelihood of a negative outcome (such as side effects or a decline in quality of life) is known to the physician and patient prior to the treatment, allowing for calculated and evidence-based decision making. However, tools to predict outcomes in older patients who need to undergo invasive treatments do not yet exist.

In the "Triaging Elderly Needing Treatment" (TENT) project the prediction of outcomes in older patients needing invasive treatment is studied. Patients from the Leiden University Medical Center aged 70 years or older and needing invasive treatment are invited to participate in the study. As part of routine clinical care, patients undergo a standardized geriatric assessment exploring the four geriatric domains: somatic disease, physical function, cognition and social environment. Additionally, patients will be followed in a standardized manner, allowing for development of predictive models for various endpoints (e.g. mortality, functional decline, quality of life). As part of the study, we will additionally assess the effectiveness of modern technology to measure physical activity in collaboration with Philips.

More Information
For more information please contact dr. Simon Mooijaart (S.P.Mooijaart@lumc.nl) or drs. Floor van Deudekom ( F.J.A.van_Deudekom@lumc.nl).