Prof. Dr. A.H.M. van der Helm - van Mil



  • Clinically suspect arthralgia
  • Early arthritis
  • Pathogenetic factors for (rheumatoid) arthritis
  • Predictive factors for the outcome of clinically suspect arthralgia and early arthritis
  • Genetics, transcriptomics, proteomics
  • Imaging, MRI


Annette van der Helm-van Mil started studying Medicine at the University of Leiden in 1993 and obtained her medical degree in 1998 (cum laude). In 2005 she got her qualification as internist and in 2006 she was ratified as rheumatologist.

She obtained her Ph.D. degree in 2006 (cum laude) on the thesis "Genetics, Autoantibodies and Clinical Features in Understanding and Predicting Rheumatoid Arthritis“ at the Leiden University .

Since 2006 she is appointed at the department of Rheumatology of the LUMC. She was head of the outpatient clinic from 2006 till 2015. Currently she is supervising the Leiden Early Arthritis Cohort, the Clinically Suspect Arthralgia cohort and the TREAT EARLIER trial. In November 2015 she is appointed as professor at the department of Rheumatology at the LUMC, and also at the Erasmus Medical Center in Rotterdam.

Her research is focused on understanding the processes underlying the course and outcome of early arthritis and clinically suspect arthralgia, in order to promote timely and individualized treatment decision making.

She performs longitudinal studies to this end. She supervises different research lines evaluating the role genetics, auto-antibodies, other serological markers and MR imaging. These projects focused on disease progression in several phases of RA. Previously she studied progression of joint destruction in patients with classified RA and progression of patients with unclassified arthritis to rheumatoid arthritis. Currently her work is concentrating on Clinically Suspect Arthralgia, the earliest possible phase to clinically identify patients with imminent RA. In order to reduce referral delays and enhance early identification of arthritis, she has initiated the Early Arthritis Recognition clinic.

She has been awarded several prizes among which the EULAR Young Investigator award, the Prof.dr Goslingsprize and the Marie-Parijs prize. In addition she has obtained several grants, among which a Klinisch Fellow grant of NWO-ZonMw, a Vidi grant of NWO, a PTO grant of NWO-ZonMw, an ERC Starting grant and several grants of the Dutch Arthritis Foundation. Her research line on early arthritis in the Medical Delta (LUMC, EMC and surrounding region) is recognized as a Research Center of Excellence by the Dutch Arthritis Society.

She has authored >295 articles in refereed journals;


Leids Universitair Medisch Centrum
Gebouw 1
Kamer C1-44

Albinusdreef 2
2333 ZA Leiden
Tel: (071 52)63423

Postzone C1-R
Postbus 9600
2300 RC Leiden