Team, Funding, PhD Theses
The +RNA virus Research team
Principal investigators:
Prof. Dr. Alexander Gorbalenya, Dr. Martijn van Hemert, Dr. Marjolein Kikkert, Prof. Dr. Eric Snijder
Senior researchers and Post-docs:
Dr. Peter Bredenbeek, Dr. Yvonne van der Meer, Dr. Sebenzile Myeni, Dr. Emmely Treffers
PhD students:
Robert Knaap, Kristina Kovacikova, Natacha Lima Leite Ogando, Mariska van Huizen, Clarisse Salgado, Melissa Thaler, Xavier Vendrell, Georg Wolff (CCB)
Research technicians:
Linda Boomaars-van der Zanden, Tim Dalebout, Ali Tas, Jessika Zevenhoven-Dobbe
External funding:
- EU H202) Marie Curie Innovative Training Network INITIATE (project 813343)
- EU H2020 A global alliance for Zika virus control and prevention ZIKAlliance (project 734548)
- EU H2020-Marie Curie European Training Network ANTIVIRALS (project 642434)
- EU EFPIA (IMI) Zoonoses Anticipation and Preparedness Initiative – ZAPI (project 115760)
- NWO-CW ECHO grant: Protein-directed ribosomal frameshifting: a novel mechanism of non-canonical translation (project 711.014.004)
- MSD Animal Health
- NWO-ALW ERASysApp: SysVirDrug: Translating Systems Virology data into broad-spectrum antiviral Drugs (project 832.14.002)
- NWO-CW TOP-GO grant: Viral RNA polymerases: the error paradox at the single-molecule level (project 700.10.352)
- EU FP7-HEALTH project SILVER (project 260644)
- EU FP7-Marie Curie Initial Training Network EUVIRNA (project 264286)
- EU FP6 project VIZIER (project 511960)
- EU FP6 project SARS-DTV (project 511064)
- NWO-ALW MEERVOUD grant: Ultrastructure and dynamics of +RNA virus replication complexes (M. Barcena; project 836.10.003)
- NWO-CW ECHO grant: Nidovirus deubiquitinating proteases: viral double edged swords (project 700.59.008)
- NWO-CW TOP grant: Hijacking membranes to accommodate viral RNA synthesis in the cytoplasm (project 700.57.301)
- NWO-CW TOP grant: Viral RNA-protein machineries: Coupling macromolecular processes during RNA virus reproduction (project 700.52.306)
- NWO-CW ECHO grant: Coronavirus RNA synthesis: how to handle errors, stops and jumps while replicating the largest RNA genome (project 700.55.002)
- NWO TopTalent subsidie: SARS-coronavirus RNA synthesis: understanding the core of a sophisticated complex (A.J. te Velthuis; project 021.001.037)
PhD theses:
- Dr. D. Oudshoorn (28 november 2017) - Wrapping up: Nidovirus membrane structures and innate immunity
- Dr. E.E. Treffers (16 Dec 2015) - A +RNA virus dyptich: Chikungunya virus-host interactions and arteriviral progammed ribosomal frameshifting
- Dr. F.E.M. Scholte (10 Dec 2015) - Host factors involved in Chikungunya virus replication
- Dr. K. Lehmann (23 Jun 2015) - Biochemistry and function of nidovirus replicase proteins
- Dr. P.B. van Kasteren (3 Dec 2014) - Arterivirus PLP2, an OTU deubiquitinase that counteracts innate immunity
- Dr. A.H. de Wilde (13 Nov 2013) - Host factors in nidovirus replication
- Dr. X. Jiang (6 Nov 2013) - Construction characterization and application of flavivirus infections
- Dr. C. Lauber (30 Oct 2012, cum laude) - On the evolution of genetic diversity in RNA virus species
- Dr. Ing. A.J.W. te Velthuis (16 May 2012, cum laude) - A biochemical portrait of the nidovirus polymerases and helicase
- Dr. P. Agostinho Gonçalves Costa da Silva (27 Jun 2011) - Functions and requirements of conserved RNA structures in the 3’ untranslated region of Flaviviruses
- Dr. K. Knoops (10 May 2011) - Nidovirus replication structures: hijacking membranes to support viral RNA synthesis
- Dr. J.M.P. Liefhebber (1 Dec 2010) - Hepatitis C virus intracellular host interactions
- Dr. D.D. Nedialkova (23 Jun 2010, cum laude) - Exploring regulatory functions and enzymatic activities in the nidovirus replicase
- Dr. D. van Aken (22 Oct 2008) - Arterivirus replicase processing: regulatory cascade or Gordian knot?
- Dr. G.A. Versteeg (21 May 2008) - Regulation of coronavirus-induced host responses
- Dr. Ir. E. van den Born (1 Feb 2006) - RNA structures regulating nidovirus RNA synthesis
- Dr. M.A. Tijms (12 May 2004) - Nsp1, a multifunctional regulator of the arterivirus life cycle
- Dr. A.O. Pasternak (8 Jan 2003) - Nidovirus transcription-regulating sequences
- Dr. R. Molenkamp (29 Nov 2000) - Nidovirus defective interfering genomes
- Dr. G. van Marle (11 Nov 1999) - Nidovirus transcription
- Dr. Ir. L.C. van Dinten (2 Nov 1999) - Equine arteritis virus replicative proteins
- Dr. J.A. den Boon (10 Oct 1996) - Equine arteritis virus, replication and transcription of a coronaviruslike virus
- Dr. R. van der Most (14 Sep 1994) - Coronavirus defective interfering RNAs, a tool to study replication, transcription and recombination