Vaccine development

Principal Investigator(s)

Dr. Marjolein Kikkert, Prof. Dr. Eric J. Snijder

Research topics

  • DUB-knockout viruses as nidovirus vaccines
  • Yellow fever virus 17D-based vaccine vectors

Key publications

  • Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs. MacFadden A, O'Donoghue Z, Silva PAGC, Chapman EG, Olsthoorn RC, Sterken MG, Pijlman GP, Bredenbeek PJ, Kieft JS. Nat Commun. 2018 Jan 9;9(1):119
  • Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression. Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL. J Biol Chem. 2014; 289:34667-82
  • Molecular and immunological characterization of a DNA-launched yellow fever virus 17D infectious clone. Jiang X, Dalebout TJ, Lukashevich IS, Bredenbeek PJ, Franco D. J Gen Virol. 2015 Apr;96(Pt 4):804-14
  • Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. van Kasteren PB, Bailey-Elkin BA, James TW, Ninaber DK, Beugeling C, Khajehpour M, Snijder EJ, Mark BL, Kikkert M. Proc Natl Acad Sci USA. 2013; 110:E838-47
  • Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs. Jiang X, Dalebout TJ, Bredenbeek PJ, Carrion R Jr, Brasky K, Patterson J, Goicochea M, Bryant J, Salvato MS, Lukashevich IS. Vaccine. 2011 Feb 1;29(6):1248-57.