Postdoc Cell Biology LUMC Leiden

Teaching & research staff

Your position

What role does the endogenous circadian clock play in our health, in our society and the biosphere? That is what you are going to investigate! The BioClock Consortium is looking for a postdoctoral researcher for their multidisciplinary team to investigate the treatment and prevention of clock-related health conditions.

In short

• This research is a joint effort by the Leiden University Medical Centre (LUMC)and the Leiden Academic Centre for Drug Research (LACDR)
• You will study clock-related health conditions and develop strategies to treat, or even prevent them
• You hold a PhD in Cell Biology or a related field, and have experience in techniques including cell culturing, analysis techniques and data handling
• Working in these research teams will give you an excellent opportunity to build up your own network and develop your own research line 

What you do

Pharmacologically targeting circadian clock dysfunction is complemental to “traditional” chronotherapies and is a novel step towards developing strategies to treat—or even prevent—clock-related health conditions. However, most of our current knowledge on clock modulators is based on laborious high-throughput screens involving several days of recording of marker activity. Our project aims to use a targeted approach by searching for the most efficient molecules or drugs affecting known crucial pathway elements in the cellular clock machinery. We plan to use cell-free and cell-based assays to test the effect of substances from large and unique libraries. The Geurink lab uses state-of-the-art technology (e.g. robot assisted acoustic liquid handling) and has vast knowledge in assay development. The Michel lab has solid background in the field of circadian clocks and provides animal models and associated tests (imaging/electrophysiology) to validate the effect of the top hits of the screen on the biological clock. The Heitman group (LACDR) works closely with our project, but focusses on identifying targets for known molecules or drugs and optimizing drug efficiency and specificity.

What we ask

You hold a PhD in Cell Biology or a related field, and have rich hands-on experience in techniques including cell culturing, CRISPR-CAS9, basic analysis techniques and data handling. Experience with plate reader (luminescence, fluorescence), assay development, reporter genes and microscope imaging techniques will be beneficial. Ideally, you must have demonstrated a strong interest in an academic career through your publication record and prior engagements in collaborative, multidisciplinary research. This position requires a person who recognizes the benefits of access to the academic resources of a top-rated research institute and the collaboration with a large industrial partner (Janssen Pharmaceuticals). This requires active exchange of ideas and information between the partners, but also between other clusters and projects within the consortium. You will achieve this because you are an enthusiastic, motivated, proactive, independent and flexible team player with excellent communicative skills in English. Working in these productive research teams will give you an excellent opportunity to build up your own network and develop your own research line.

More information

Visit our website for more information about the BioClock Consortium.

The appointment is for three years. Your salary will depend on your qualifications and experience, with a maximum of € 4,800 gross per month (Scale 10, CAO UMC).

For more information about this position, please contact Dr. Stephan Michel, S.H.michel@lumc.nl  or Dr. Paul Geurink, P.P.Geurink@lumc.nl.

Acquisition in response to this vacancy is not appreciated.

Leoni Abendstein

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Your workplace

You will be part of the multidisciplinary Dutch BioClock Consortium investigating the role of the endogenous circadian clock in health, our society and the biosphere. The work package titled “Clock medicines” is led by Prof. L. Heitman of the Leiden Academic Centre for Drug Research (LACDR) and the project you will be working on by Dr. S.H. Michel and Dr. P.P. Geurink at the Department of Cell and Chemical Biology of the Leiden University Medical Centre (LUMC).  

Your career at the LUMC

Getting better at ground-breaking levels; that's our mission. This applies not only to healthcare, but also to our employees. In order to be able to continue to learn and develop, we offer internal and external training. You are also entitled to an end-of-year bonus (8,3%), holiday allowance, sports budget and bicycle scheme. In addition you can make use of our pension scheme at ABP, where LUMC pays no less than 70% of your pension premium, causing your net salary to be higher.

Contact: Stephan Michel, Assistant Professor, department of Cell and Chemical Biology
+31 (0)71 5269772
email: s.h.michel@lumc.nl

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