- Glycan analysis
- Type 2 diabetes
- Human nutrition
Dr. Viktoria Dotz studies complex sugar structures (glycans) attached to proteins in blood plasma in the context of diseases, with a focus on type 2 diabetes. For this, she develops workflows for sample preparation and mass spectrometry analysis using MALDI-TOF-MS and LC-MS. The methods are applied on plasma samples from large clinical cohorts, in collaboration with clinicians from LUMC, ErasmusMC Rotterdam and other hospitals. The overall goal is to find biomarkers that can support early disease detection and provide leads for novel therapeutic strategies.
The challenges she tackles hereby are:
- Measuring large sample sets requires the use of robust, automated methods suitable for a high-throughput (several hundreds to thousands of samples).
- The large amount of data generated by high-throughput applications using high-resolution mass spectrometry instrumentation requires specialized data processing software and tailored bioinformatics strategies.
Leids Universitair Medisch Centrum
2333 ZC Leiden
Tel: +31 71 5268701
2300 RC Leiden