Hereditary Tumour Pathology

Project leaders: Prof. Dr. H. Morreau, Dr. T van Wezel

CRC is one of the most important cancer types according to prevalence and mortality with each year approximately 10,000 new cases diagnosed in the Netherlands. The lifetime risk for CRC is about 5%, and the 5-year survival is about 50%. Inherited susceptibility underlies over 30% of all CRC cases and up to 5% of all CRC cases can currently be explained by the known inherited CRC syndromes Lynch syndrome, familial adenomatous polyposis (FAP) and MUTYH associated polyposis (MAP). Recent genome-wide association studies (GWAS) identified several more common, low-risk variants that can explain a further part of the heritable CRC risk.

In our research we focus on

  • The molecular pathology and tumour genetics of familial colorectal cancer, both with known and unknown underlying causes
  • The molecular pathology of colorectal cancer with the aim to develop new molecular diagnostic markers and profiles for early detection and better treatment

Current projects