Key Publications


  • Pike-Overzet,K., Rodijk,M., Ng,Y.Y., Baert,M.R., Lagresle-Peyrou,C., Schambach,A., Zhang,F., Hoeben,R.C., Hacein-Bey-Abina,S., Lankester,A.C., Bredius,R.G., Driessen,G.J., Thrasher,A.J., Baum,C., Cavazzana-Calvo,M., van Dongen,J.J., Staal,F.J.(2011) Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer. Leukemia 25: 1471-1483. [Pubmed]
  • Koppers-Lalic, D., Hoeben, R.C. (2011) Non-human viruses developed as therapeutic agent for use in humans. Rev. Med. Virol. 21: 227-239. [PubMed]
  • Van den Hengel, S.K., De Vrij, J., Uil, T.G., Lamfers, M.M., Sillevis Smitt, P.A.E., Hoeben,R.C. Truncating the i-leader open reading frame enhances release of human adenovirus type 5 in glioma cells. Virol.J. 8:162. [PubMed]
  • Ilett, E.J., Bárcena, M., Errington-Mais, F., Griffin, S., Harrington, K., Pandha, H., Coffey, M., Selby, P.J., Limpens, R.W., Mommaas, M., Hoeben, R.C., Vile, R.G.,  Melcher, A.A. (2011) Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization. Clin. Cancer Res. 17:2767-2776. [PubMed]
  • Uil, T.G., Vellinga, J., De Vrij,J., Van den Hengel, S.K., Rabelink, M.J.W.E., Cramer, S.J., Eekels, J.J.M., Ariyurek, Y., van Galen, M., Hoeben, R.C. (2011) Directed adenovirus evolution using engineered mutator viral polymerases. Nucl. Acids Res. 39: e30. [PubMed]
  • De Vrij, J., Van den Hengel, S.K., Uil, T.G., Koppers-Lalic, D., Dautzenberg, I.J.C., Stassen, O., Barcena, M., Yamamoto, M., De Ridder, C., Kraaij, R., Kwappenberg, K., Schilham, M., Hoeben, R.C. (2011) Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors. Virology 410:192-200. [PubMed]
  • De la Garza-Rodea, A.S., Verweij, M.C., Boersma, H., van der Velde-van Dijke, I.,  de Vries, A.A.F., Hoeben, R.C., van Bekkum, D.W., Wiertz, E.J.H.H., Knaän-Shanzer, S. (2011) Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants. PLoS ONE 6: e14493. [PubMed]
  • Eerligh, P., van Lummel, M., Zaldumbide, A., Moustakas, A.K.,  Duinkerken, G., Bondinas, G., Koeleman, B.P.,  Papadopoulos. G.K., Roep, B.O. (2011) Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes. Genes Immun. 12: 415-427. [PubMed]
  • Koninckx, R., Daniëls, A., Windmolders, S., Carlotti, F., Mees, U., Steels, P., Rummens, J.L., Hendrikx, M., Hensen, K. (2011) Mesenchymal stem cells or cardiac progenitors for cardiac repair? A comparative study. Cell. Mol. Life Sci. 68: 2141-2156. [PubMed]


  • Carlotti, F., Zaldumbide, A., Loomans, C.J., Van Rossenberg, E., Engelse, M., De Koning, E.J., Hoeben, R.C. (2010)  Isolated human islets contain a distinct population of mesenchymal stem cells. Islets 2: 164-173. [PubMed]
  • De Vrij, J., Willemsen, R.A., Lindholm. L., Hoeben, R.C. and the GIANT consortium*(2010) Adenovirus-derived vectors for prostate cancer gene therapy. Human Gene Ther. 21:795-805. [PubMed] (*the GIANT Consortium consists of Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ, de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P, Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G)
  • Louz, D., Bergmans, H.E., Loos, B.P., Hoeben, R.C. (2010) Emergence of viral diseases: mathematical modeling as tool for infection control, policy and decision making. Crit. Rev. Microbiol. 36: 195-211. [PubMed]
  • Schenk. E., Essand. M., Bangma. C.H. and the GIANT FP6 Consortium* (2010)  Clinical adenoviral gene therapy for prostate cancer. Hum Gene Ther. 21:807-813. [PubMed] (*the GIANT Consortium  consists of Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Danielsson A, Dautzenberg IJ, Dzojic H, Erbacher P, Fisher K, Frazier A, Georgopoulos LJ, Hoeben R, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Lindholm L, Magnusson M, Maitland N, Neuberg P, Nilsson B, Ogris M, Remy JS, Scaife M, Schooten E, Seymour L, Totterman T, Uil TG, Ulbrich K, Veldhoven-Zweistra JL, de Vrij J, van Weerden W, Wagner E, Willemsen R)
  • Zaldumbide, A., Carlotti, F., Weening, S., Hoyng, S., Cramer, S.J., Rabelink, M.J.W.E., Verhaagen, J., Hoeben, R.C. (2010) A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator. Biotechnol. Lett. 32: 749-754. [PubMed]
  • Kleijwegt, F.S., Laban, S., Duinkerken, G., Joosten, A.M., Zaldumbide, A., Nikolic, T., Roep, B.O. (2010) Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J. Immunol. 185(3):1412-1418 [Pubmed]
  • Lam, S., Lodder, K., Teunisse, A.F., Rabelink, M.J.W.E., Schutte, M, Jochemsen, A.G. (2010) Role of Mdm4 in drug sensitivity of breast cancer cells. Oncogene 29: 2415-2426. [PubMed]


  • Wang, X., Herr, R.A., Rabelink, M., Hoeben, R.C., Wiertz, E.J., Hansen, TH. (2009) Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. J. Cell Biol.187: 655–668  [PubMed]
  • Van den Wollenberg, D.J., Van den Hengel, S.K., Dautzenberg, I.J., Kranenburg, O.,  Hoeben, R.C. (2009) Modification of mammalian reoviruses for use as oncolytic agents. Expert Opin.  Biol. Ther. 9:1509-1520. [PubMed]
  • Uil, T.G., De Vrij, J., Vellinga, J., Rabelink, M.J., Cramer, S.J., Chan, O.Y., Pugnali, M., Magnusson, M., Lindholm, L., Boulanger, P. Hoeben, R.C. (2009) A new adenovirus fiber-pseudotyping approach for expedited functional assessment of candidate retargeted fibers. J. Gene Med. 11: 990-1004. [PubMed]
  • Bernhardt, U., Carlotti, F., Hoeben, R.C., Joost, H.G., Al-Hasani, H. (2009) A dual role of the N-terminal FQQI motif in GLUT4 trafficking. (2009) Biol. Chem. 390:883-892. [PubMed]
  • Kuiperij, H.B., Van Pel, M., De Rooij, K.E., Hoeben, R.C., Fibbe, W.E. (2009) Serpina1 (a1-AT) is synthesized in the osteoblastic stem cell niche. Exp. Hematol. 37:641-647 [PubMed]


  • Chadt, A., Leicht, K., Deshmukh, A., Jiang, L.Q., Scherneck, S., Bernhardt, U., Dreja, T., Vogel, H., Schmolz, K., Kluge, R., Zierath, J.R., Hultschig, C., Hoeben, R.C., Schürmann, A., Joost, H.G., Al-Hasani, H. (2008) A mutation in the positional candidate gene Tbc1d1 in the SJL mouse strain confers leanness and protects from high-fat diet induced obesity. Nat. Genet. 40:1354-1359. [PubMed]
  • De Poorter, J.J., Hoeben, R.C., Obermann, W.R., Huizinga, T.W., Nelissen, R.G. (2008) Gene therapy for the treatment of hip prosthesis loosening: adverse events in a  phase 1 clinical study. Hum. Gene. Ther. 19: 1029-1038. [PubMed]
  • Van den Wollenberg, D.J.M., Van den Hengel, S.K., Dautzenberg, I.J.C., Cramer, S.J., Kranenburg, O., Hoeben, R.C. (2008) A strategy for genetic modification of the spike-encoding segment of human reovirus T3D for reovirus targeting. Gene Ther. 15:1567–1578. [PubMed]
  • Schagen, F.H.E., Graat, H.C.A. Carette, J.E., Vellinga, J., Van Geer, M.A., Hoeben, R.C., Dermody, T.S., Van Beusechem, V.W. (2008) Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice. Hum. Gene Ther. 19:783-794. [PubMed]
  • Eggers, R., Hendriks, W.T., Tannemaat, M.R., Van Heerikhuize, J.J., Pool, C.W., Carlstedt, T.P., Zaldumbide, A., Hoeben, R.C., Boer, G.J., Verhaagen J. (2008) Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots. Mol. Cell. Neurosci. 39:105-117. [PubMed]
  • Carlotti, F., Zaldumbide, A., Charif, H., De Koning, E.J., Luider, T.M., Hoeben, R.C. (2008) The 45-kDa form of Pdx-1 does not result from post-translational modifications. Biochim. Biophys. Res. Commun. 370: 225-229. [PubMed]
  • De Vrij, J.,  Uil, T.G., Van den Hengel, S.K., Cramer, S.J., Koppers-Lalic, D., Verweij, M.C., Wiertz, E.J.H.J., Vellinga, J., Willemsen, R.A., Hoeben, R.C. (2008) Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX. Gene Ther.  15: 978–989. [PubMed]
  • Van Houdt, W.J., Smakman, N., Van den Wollenberg D.J.M., Emmink, B.L., Veenendaal, L.M., Van Diest P.J., Hoeben, R.C., Borel Rinkes, I.H.M., Kranenburg, O. (2008) Transient infection of freshly isolated human colorectal tumor cells by Reovirus T3D intermediate subviral particles. Cancer Gene Ther. 15: 284-292. [PubMed]
  • Hamdi, M., Popeijus, H.E., Carlotti, F., Janssen, J.M., van der Burgt, C., Cornelissen-Steijger, P., van de Water, B., Hoeben, R.C., Matsuo, K., van Dam, H. (2008) ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses. DNA Repair (Amst.) 7: 487-496. [PubMed]
  • De Poorter, J.J., Hoeben, R.C., Hogendoorn, S., Mautner, V., Ellis, J., Obermann, W.R., Huizinga T.W.J., Nelissen, R.G.H.H. (2008) Gene therapy and cement injection for restabilization of loosened hip prosthesis. Hum Gene Ther. 19: 83-95. [PubMed]
  • Zaldumbide, A., Hoeben, R.C. (2008) How not to be seen: Immune-evasion strategies in gene therapy. Gene Ther. 15: 239–246. [PubMed]
  • Louz, D., Bergmans, H.E., Loos, B.P., Hoeben, R.C. (2008) Reappraisal of biosafety risks posed by PERVs in xenotransplantation. Rev. Med. Virol. 18: 53-65. [PubMed]


  • Hendriks, W.T.J., Eggers, R., Carlstedt, T.P., Zaldumbide, A., Tannemaat, M.R., Fallaux, F.J., Hoeben, R.C., Boer, G.J., Verhaagen, J. (2007) Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune "stealth" transgene. Restor. Neurol. Neurosci. 25:585-599. [PubMed]
  • Sebestyen, Z., De Vrij, J., Magnusson, M., Debets, R., Willemsen R. (2007)An oncolytic adenovirus redirected with a tumor-specific T-cell receptor. Cancer Res.  6: 11309-11316. [PubMed]
  • Lie-Venema, H., van den Akker, N.M.S., Bax, N.A.M., Winter, E.M., Maas, S., Kekarainen, T., Hoeben, R.C., De Ruiter, M.C., Poelmann, R.E., Gittenberger-de Groot, A.C.  (2007) Origin, fate and function of epicardium-derived cells (EPDCS) in normal and abnormal heart development. ScientificWorldJournal 7: 1777–1798. [PubMed]
  • Ter Horst, M., Brouwer, E., Verwijnen, S., Rodijk, M., De Jong, M., Hoeben, R., De Leeuw, B., Sillevis Smitt, P. (2007) Targeting malignant gliomas with a GFAP-selective oncolytic adenovirus. J. Gene Med. 9: 1071–1079. [PubMed]
  • Schenk-Braat, E.A.M., Kaptein, L.C.M., Hallemeesch, M.M.,  Bangma, C.H., Hoeben, R.C. (2007) Gene Therapy in The Netherlands: highlights from the Low Countries. J. Gene Med. 9: 895-903. [PubMed]
  • Kakkola, L., Tommiska, J., Boele, L.C.L., Miettinen, S., Blom, T., Kekarainen, T., Qui, J., Pintel, D., Hoeben, R.C., Hedman, K., Söderlund-Venermo, M. (2007) Construction and biological activity of a full-length molecular clone of human Torque Teno Virus (TTV) genotype 6. FEBS Journal 274: 4719-4730. [PubMed]
  • De Poorter, J.J., Lipinski, K.S., Nelissen, R.G., Huizinga,T.W., Hoeben, R.C. (2007) Optimization of short-term transgene expression by sodium butyrate and Ubiquitous Chromatin Opening Elements (UCOEs). J.Gene Med. 9: 639–648. [PubMed]
  • Ossevoort, M., Zaldumbide, A., te Velthuis, A.J., Melchers, M., Ressing, R.E., Wiertz, E.J., Hoeben, R.C. (2007) The nested open reading frame in the Epstein-Barr Virus Nuclear Antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis. Mol. Immunol. 44: 3588-3596. [PubMed]
  • Magnusson, M.K., Henning, P., Myhre, S., Wikman, M., Uil, T.G., Friedman, M., Andersson, K.M.E., Hong, S.S., Hoeben, R.C., Habib, N.A., Ståhl, S., Boulanger, P., Lindholm, L. (2007) An adenovirus 5 vector genetically re-targeted by an Affibody™ molecule with specificity for the tumor antigen HER2/neu. Cancer Gene Ther. 14: 468-479. [PubMed]
  • Vellinga, J.,  de Vrij, J., Myhre, S., Uil, T., Martineau, P., Lindholm, L., Hoeben, R.C. (2007) Efficient incorporation of a functional hyper-stable single-chain antibody fragment protein-IX fusion in the adenovirus capsid. Gene Ther. 14: 664-670. [PubMed]
  • Zaldumbide, A., Ossevoort, M., Wiertz, E.J.H.J., Hoeben, R.C. (2007) In-cis inhibition of antigen processing by the latency-associated nuclear antigen I of kaposi sarcoma herpes virus. Mol. Immunol. 44: 1352-1360. [PubMed]
  • Brouwer, E., Havenga, M.J., Ophorst, O., De Leeuw, B., Geysbers, L., Gillissen, G., Hoeben, R.C., Ter Horst, M., Nanda, D., Dirven, C., Avezaat, C.J., Goudsmit, J., Sillevis Smitt, P. (2007) Human adenovirus type 35 vector for gene therapy of brain cancer: Improved transduction and bypass of pre-existing anti-vector immunity in cancer patients. Cancer Gene Ther. 14: 211-219. [PubMed]


  • Raz, V., Carlotti, F., Vermolen, B.J., Van der Poel, E., Sloos, W.C.R., Knaan-Shanzer, S., De Vries, A.A.F., Hoeben, R.C., Young, T.I., Tanke, H.J., Garini, Y., Dirks, R.W. (2006) Changes in nuclear lamina triggers spatial reorganization of heterochromatin regions in caspase-8-activated human mesenchymal stem cells. J. Cell Sci. 119: 4247-4256. [PubMed]
  • Hoeben, R.C., Uil, T., De Vrij, J., De Vries, A.A.F., Vellinga, J., (2006) Adenoviruses: The Long March From “Oncogenic” to “Oncolytic” Virus. CHEMTRACTS — Biochemistry and Molecular Biology 19: 226–237.
  • Ter Horst, M., Verwijnen, S.M., Brouwer, E., Hoeben, R.C., De Jong, M., De Leeuw, B.H.C.G.M., Sillevis Smitt, P.A.E. (2006) Locoregional delivery of adenoviral vectors. J. Nucl. Med. 47: 1483-1489. [PubMed]
  • Van der Vliet, P.C., Hoeben R.C. (2006) Adenoviruses in: DNA Replication and Human Disease (Edited by DePamphilis, M.L.) Cold Spring Harbor Monograph Series (ISBN 0-87969-766-0). pp.645-661.
  • Smakman, N., Van den Wollenberg, D.J.M., Elias, S.G., Sasazuki, T., Shirasawa, S., Hoeben, R.C., Borel Rinkes, I.H.M., Kranenburg, O. (2006) KRASD13 promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin, but not by TRAIL. Cancer Res. 66: 5403-5408 [PubMed]
  • Smakman, N., Van der Bilt, J.D.W., Van den Wollenberg, D.J.M., Hoeben, R.C., Borel Rinkes, I.H.M., Kranenburg, O. (2006) Immunosuppression promotes reovirus therapy of colorectal liver metastases. Cancer Gene Ther. 13: 815-818. [PubMed]
  • Ossevoort, M., Zaldumbide, A., Cramer, S.J., Van der Voort, E.I.H., Toes, R.E.M., Hoeben, R.C. (2006) Characterization of an immuno’stealth’ derivative of the herpes simplex virus thymidine kinase gene. Cancer Gene Ther. 13: 584-591 [PubMed]
  • De Leeuw, B., Su, M., Ter Horst, M., Iwata, S., Rodijk, M., Hoeben, R.C., Messing, A., Sillevis Smitt, P.A., Brenner, M. (2006) Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elements. J. Neurosci. Res. 83: 744-753. [PubMed]
  • Rademaker, H.J., Fallaux, F.J., Van den Wollenberg, D.J.M., De Jong, R.N., Van der Vliet, P.C., Hoeben, R.C. (2006) Relaxed template specificity in fowl adenovirus-1 DNA replication initiation. J.Gen. Virol. 87: 553-562. [PubMed]
  • Vellinga, J., Uil, T.G., De Vrij, J., Rabelink, M.J.W.E., Lindholm, L., Hoeben, R.C. (2006) A system for efficient generation of adenovirus protein IX-producing helper cell lines. J. Gene Med. 8: 147-154. [PubMed]


  • Vellinga, J.,Van den Wollenberg, D.J.M., Van der Heijdt, S., Rabelink, M.J.W.E., Hoeben, R.C. (2005) The coiled-coil domain of the adenovirus type 5 protein IX is dispensable for capsid incorporation and thermostability. J. Virol. 79: 3206-3210. [PubMed]
  • Smakman, N., Van den Wollenberg, D.J.M., Borel Rinkes, I.H.M., Hoeben, R.C., Kranenburg, O. (2005) Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D. J. Virol. 79: 14981-14985. [PubMed]
  • Hamdi, M., Kool, J., Cornelissen-Steijger, P., Carlotti, F., Popeijus, H.E., Van der Burgt, C., Janssen, J.M., Yasui, A., Hoeben, R.C., Terleth, C., Mullenders, L.H., Van Dam, H. (2005) DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1. Oncogene 24: 7135-7144. [Pubmed]
  • Carlotti, F., Zaldumbide, A., Martin, P., Boulukos, K.E., Hoeben, R.C., Pognonec, P. (2005) Development of an inducible suicide gene system based on human caspase 8. Cancer Gene Ther. 12: 627-639. [PubMed]
  • Bottley, G., Cook, G.P., Meade, J.L., Holt, J.R., Hoeben, R.C., Blair, G.E. (2005) Differential expression of LFA-3, Fas and MHC Class I on Ad5- and Ad12-transformed human cells and their susceptibility to Lymphokine Activated Killer (LAK) cells. Virology 338: 297-308. [PubMed]
  • Vellinga, J., Van der Heijdt, S., Hoeben, R.C. (2005) The adenovirus capsid: major progress in minor proteins. J. Gen. Virol.  86: 1581-1588. [PubMed]
  • Bazuine, M., Carlotti, F., Rabelink, M.J.W.E., Vellinga, J., Hoeben, R.C., Maassen, J.A. (2005) The p38 MAPK-inhibitor SB203580 reduces glucose turnover by the GLUT4 transporter of 3T3-L1 adipocytes in the insulin-stimulated state. Endocrinology 146: 1818-1824. [PubMed]
  • De Poorter, J.J., Tolboom, T.C.A., Rabelink, M.J.W.E., Pieterman, E., Hoeben, R.C., Nelissen, R.G.H.H., Huizinga, T.W.J. (2005) Towards gene therapy in prosthesis loosening: efficient killing of interface cells by gene-directed enzyme prodrug therapy with nitroreductase and the prodrug CB1954. J. Gene Med. 7: 1421-1428 [PubMed]
  • Louz, D., Bergmans, H.E., Loos, B.P., Hoeben, R.C. (2005) Cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and for live-virus vaccination. J. Gene Med. 7: 1263-1274. [PubMed]
  • Zadelaar, A.S.M., Von der Thüsen, J.M., Boesten, L.S.M., Hoeben, R.C., Kockx, M.M., Versnel, M.A., Van Berkel, T.J.C., Havekes, L.M., Biessen, E.A.L., Van Vlijmen, B.J.M. (2005) Increased vulnerability of pre-existing atherosclerotic plaques in apolipoprotein E deficient mice following adenovirus-mediated gene transfer of Fas ligand. Atherosclerosis 183: 244-250 [PubMed]
  • Offringa, R., Kwappenberg, K., Rabelink, M., Rea, D., Hoeben, R. (2005) Adenoviral transduction of dendritic cells.  Methods Mol. Med. 109: 83-96. [PubMed]


  • Van der Eb, M.M., De Leeuw, B., Van der Eb, A.J., Hoeben, R.C. (2004) Side effects of suicide gene therapy. Methods Mol. Med. 90: 479-490. [PubMed]
  • Carlotti, F., Bazuine, M., Kekarainen, T., Seppen J., Pognonec, P., Maassen, J.A., Hoeben, R.C. (2004) Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes. Mol. Ther. 9: 209-217. [PubMed]
  • Oruetxebarria, I., Venturini, F., Kekarainen, T., Houweling, A., Zuijderduijn, L.M.P., Mohd-Sarip, A., Hoeben, R.C., Verrijzer, C.P. (2004) p16INK4a is required for hSNF5 chromatin-remodeler induced cellular senescence in malignant rhabdoid tumor cells. J. Biol. Chem. 279: 3807-3816. [PubMed]
  • Vellinga, J., Rabelink, M.J.W.E., Cramer, S.J., Van den Wollenberg, D.J.M., Van der Meulen, H., Leppard, K.N., Fallaux, F.J., Hoeben, R.C. (2004) Spacers increase the accessibility of peptide ligands linked to the carboxyl terminus of the adenovirus minor capsid protein IX. J.Virol. 78: 3470-3479. [PubMed]
  • Schagen, F.H.E., Ossevoort, M., Toes, R.E.M., Hoeben, R.C. (2004) Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion. Crit. Rev. Oncol. Hemat. 50: 51-70. [PubMed]
  • Verwijnen, S.M., Sillevis Smitt, P.A.E., Hoeben, R.C., Rabelink, M.J.W.E., Wiebe, L., Curiel, D.T., Hemminki, A., Krenning, E.P., De Jong, M. (2004) Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the Herpes Simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene. Cancer Biother. Radiopharm. 19: 111-120. [PubMed]
  • Bazuine, M., Carlotti, F., Jahangir Tafrechi, R.S., Hoeben, R.C., Maassen, A.J. (2004) Mitogen-Activated Protein Kinase (MAPK) Phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin-resistance in 3T3-L1 adipocytes. Mol. Endocrinol. 18: 1697-1707. [PubMed]
  • Avvakumov, N., Kajon, A.E., Hoeben, R.C., Mymryk, J.S. (2004) Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses. Virology 329: 477-492. [PubMed]
  • Rea,D., LaFace, D., Hutchins, B., Kwappenberg, K., Melief, C.J.M., Hoeben, R.C., Offringa, R. (2004) Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10-producing CD4+ T cells. Hum. Immunol. 65: 1344–1355. [PubMed]


  • Willems van Dijk, K., Kypreos, K.E., d'Oliveira, C., Fallaux, F.J. (2003) Adenovirus-mediated gene transfer. Methods Mol. Biol. 209: 231-247. [PubMed]
  • Van der Eb M.M. (2003) Gene therapy for solid tumors. PhD thesis, Leiden.
  • Abou El Hassan, M.A.I., Heijn, M., Rabelink, M.J.W.E., Van der Vijgh, W.J.F., Bast, A., Hoeben, R.C. (2003) The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells. Cancer Gene Ther. 10: 270-277. [PubMed]
  • Lard, L.R., Van Gaalen, F.A., Schonkeren, J.J.M., Pieterman,E.J., Stoeken, G., Vos, K.,  Nelissen, R.G.H.H., Westendorp, R.G.J., Hoeben, R.C., Breedveld, F.C., Toes, R.E.M., Huizinga, T.W.J. (2003) Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis. Arthritis Rheum. 48: 1841-1848. [PubMed]
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  • See also: Von der Thüsen, J.H., Van Berkel, T.J.C., Biessen, E.A.L., Hoeben, R.C., Van Vlijmen, B.J.M., Havekes, L.M., Kocks, M.M. (2002) Unraveling the mechanisms of plaque rupture in murine models. Circulation 106: e186 (letter to the editor). [PubMed]  


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  • Schagen, F.H.E., Rademaker, H.J., Cramer, S.J., Van Ormondt, H., Van der Eb, A.J., Van de Putte, P., Hoeben, R.C. (2000) Towards integrating vectors for gene therapy: Expression of functional bacteriophage MuA and MuB proteins in mammalian cells. Nucleic Acids Res. 28: e104. [PubMed]