Annemarthe van der Veen

Annemarthe van der Veen heads the Innate Immunity group that studies how innate immune mechanisms control sterile inflammation. She did her PhD research in the laboratory of Prof. Hidde Ploegh at the Whitehead Institute (Cambridge, USA), where she worked on ubiquitin-like proteins and their role in cellular homeostasis and stress responses. After she obtained her PhD degree in 2011, she joined the laboratory of Prof. Caetano Reis e Sousa at The Francis Crick Institute in London. Here, she studied the innate immune mechanisms that are important for anti-viral immunity. She investigated how the activation of RNA sensors by viral RNA in the cytosol of infected cells controls the production of type I Interferons (IFNs), which are essential anti-viral cytokines. In 2019, she joined the LUMC as an assistant professor. Taking a biochemical and molecular approach, her group studies how the RNA sensing pathway is activated by self-derived (rather than viral) ligands, leading to type I IFN induction in the absence of an infection. An IFN-based sterile inflammatory response contributes to autoinflammatory and autoimmune diseases and impacts on anti-tumor immunity and tumor rejection. Dr. Van der Veen holds a tenure track position at the Institute of Chemical Immunology (ICI), a virtual institute subsidized by an NWO Gravitation grant.