Alloimmunity

The aim of this research area is to gain more insight into the regulation of the alloimmune response with the goal to use this knowledge for the benefit of clinical transplantation, reproductive immunology, and blood transfusion. This research is performed in the section of Immunogenetics and Transplantation Immunology (ITI).

The transplant related research is embedded in the LUMC Transplant Center and is mainly focused on:

  • The differential immunogenicity of HLA disparities between patient and donor
  • The humoral immune response directed at the transplanted organ
  • HLA diagnostics laboratory
  • Personalized medicine to facilitate transplantation of highly sensitized patients through definition of acceptable HLA mismatches (Eurotransplant Acceptable Mismatch Program)

 

The reproductive immunology research is dedicated to maternal immune regulation towards the unborn child. This research focusses on the differences between normal pregnancies and pregnancies during which an aberrant immune regulation is expected:

  • Recurrent miscarriages; in this situation a lack of immune regulation is a probable cause.
  • Oocyte donation: here, the fetus is completely allogeneic compared to the mother, hence we expect a high level of immune regulation in successful oocyte donation pregnancies.

For this research, molecular, serological and cellular assays are used. There is close collaboration between other research groups within the IHB, as well as the departments of Surgery, Pediatrics,  Nephrology, Pathology, Anatomy and Embryology, and Obstetrics.