- Host-pathogen interactions
- Systems immunology
- Mucosal immunity
Simon Jochems is a senior researcher working at the Center for Infectious Disease at the LUMC. He obtained his BSc and MSc in Biomedical Sciences from Utrecht University. During his master he conducted a 6-month research internship at Yerkes, Emory University where he worked on understanding the mechanisms driving immune activation during HIV infection. He continued this research during his PhD studies in the Institut Pasteur, Paris, where he worked in the group of Michael Muller-Trutwin embedded in the laboratory of prof Françoise Barré-Sinoussi. He obtained his PhD cum laude in 2015 and then moved to the Liverpool School of Tropical Medicine for his postdoctoral research. There he worked in the experimental human pneumococcal challenge model and developed novel assays to study human immune responses in the nose in response to bacterial and viral infections. In 2019 he obtained a Marie Sklodowska Curie “LEaDing” Fellowship to move to LUMC and apply machine learning tools and multi-omics data integration to define signatures of protection against infection. He is also continuing his research into the identification of correlates of protection against pneumococcal infections and the development of further applications for minimally-invasive mucosal sampling tools. In the future, Simon will continue his research to improve our understanding of immune responses in the setting of infectious diseases with a particular interest in how chronic and acute inflammation can alter immunity.
Langenberg MCC, Hoogerwerf MA, Koopman JPR, Janse JJ, Kos-van Oosterhoud J, Feijt C, Jochems SP, de Dood CJ, van Schuijlenburg R, Ozir-Fazalalikhan A, Manurung MD, Sartono E, van der Beek MT, Winkel BMF, Verbeek-Menken PH, Stam KA, van Leeuwen FWB, Meij P, van Diepen A, van Lieshout L, van Dam GJ, Corstjens PLAM, Hokke CH, Yazdanbakhsh M, Visser LG, Roestenberg M. A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics. Nature Medicine. 2020 Mar;26(3):326-332
De Ruiter K*, Jochems SP*, Tahapary D, Stam K, Konig M, Laban S, Van Unen V, Hollt T, Mbow M, Lelieveldt BPF, Koning F, Sartono E, Smit JWA, Supali T, Yazdanbakhsh M. Helminth infections drive heterogeneity in human type 2 and regulatory cells. Science Translational Medicine. 2020 doi: 10.1126/scitranslmed.aaw3703
Mitsi E, Carniel B, Reiné J, Rylance J, Zaidi S, Soares-Schanoski A, Connor V, Collins AM, Schlitzer A, Nikolaou E, Solórzano C, Pojar S, Hill H, Hyder-Wright AD, Jambo KC, Oggioni MR, De Ste Croix M, Gordon SB, Jochems SP*, Ferreira DM*. Nasal pneumococcal density is associated with microaspiration and heightened human alveolar macrophage responsiveness to bacterial pathogens. American Journal of Respiratory and Critical Care Medicine. 2019 doi 10.1164/rccm.201903-0607OC
Nikolaou E, Blizard A, Pojar S, Mitsi E, German EL, Reiné J, Hill H, McNamara PS, Collins A, Ferreira DM*, Jochems SP*. Minimally-invasive nasal sampling in children offers accurate pneumococcal colonization detection. Paediatric Infectious Diseases Journal. 2019 doi:10.1097.
Jochems SP*, De Ruiter K*, Solórzano C*, Voskamp A*, Mitsi E, Nikolaou E, Carniel BF, Pojar S, German EL, Reiné J, Soares-Schanoski A, Hill H, Robinson R, Hyder-Wright AD, Weight CM, Durrenberger PF, Heyderman RS, Gordon SB, Smits HH, Urban BC, Rylance J, Collins AM, Wilkie MD, Lazarova L, Leong SC, Yazdanbakhsh M, Ferreira DM. Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization. Journal of Clinical Investigation. 2019 130, doi:10.1172/JCI128865.
Jochems SP*, Marcon F*, Carniel BF, Holloway M, Mitsi E, Smith E, Gritzfeld JF, Solorzano C, Reine J, Pojar S, Nikolaou E, German EL, Hyder-Wright A, Hill H, Hales C, de Steenhuijsen Piters WAA, Bogaert D, Adler H, Zaidi S, Connor V, Gordon SB, Rylance J, Nakaya HI, Ferreira DM. Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. Nature Immunology. 2018 Dec;19(12):1299-1308.
De Steenhuijsen-Piters W, Jochems SP, Mitsi E, Rylance J, Pojar S, Nikolaou E, German E, Holloway M, Carniel B, Chu ML, Arp K, Sanders E, Ferreira D, Bogaert B. Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine. Nature Communications. 2019 Jul5;10(1):2981.
Rylance J, de Steenhuijsen Piters WAA, Mina MJ, Bogaert D, French N, Ferreira DM; EHPC-LAIV Study Group. Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization. Am J Respir Crit Care Med. 2019 May 1;199(9):1160-1163
Jochems SP*, Piddock K*, Rylance J, Adler H, Carniel BF, Collins A, Gritzfeld JF, Hancock C, Hill H, Reine J, Seddon A, Solorzano C, Sunny S, Trimble A, Wright AD, Zaidi S, Gordon SB, Ferreira DM. Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash. PLoS One 2017; 12: e0169805.
Jochems SP, Petitjean G, Kunkel D, Liovat AS, Ploquin MJ, Barre-Sinoussi F, Lebon P, Jacquelin B, Muller-Trutwin MC. Modulation of type I interferon-associated viral sensing during acute simian immunodeficiency virus infection in African green monkeys. J Virol 2015; 89: 751-762.
A full list of publications can be found here
Reiné J, Carniel BF, Solórzano C, Mitsi E, Pojar S, Nikolaou E, German EL, Hyder-Wright AD, Hill H, Hales C, Brown L, Horsley V, Hughes L, Zaidi S, Connor V, Morton B, Collins AM, Rylance J, Adler H, McNamara PS, Ferreira DM, Jochems SP. Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan. bioRxiv
Carniel BF, Marcon F, Rylance J, Zaidi S, Reine J, Negera E, Nikolaou E, Pojar S, Colorzano, Collins A, Connor V, Bogaert D, Gordon SB, Nakaya H, Ferreira DM*, Jochems SP*, Elena Mitsi*. Pneumococcal colonization impairs nasal and lung mucosal immune responses to Live Attenuated Influenza Vaccination in adults. medRxiv
Nikolaou E*, Jochems SP*, Mitsi E, Pojar S, Negera E, Reine J, Carniel B, Soares-Schanoski A, Connor V, Adler H, Zaidi SR, Hales C, Hill H, Hyder-Wright A, Gordon SB, Rylance J, Ferreira DM. Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization. bioRxiv
Adler H, et al.Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic. medRxiv
Pichon F, Busato F, Jochems SP, Jacquelin B, Le Grand R, Deleuze J-F, Müller-Trutwin M, Tost J. Analysis and annotation of genome-wide DNA methylation patterns in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips. bioRxiv
Pojar S, et al. Isolate differences in colonization efficiency during experimental human pneumococcal challenge. medRxiv
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